JF1/Ms (Japanese Fancy Mouse) was derived from a mouse stock purchased from a market in Denmark, and has been identifed as belonging to species M. m. molossinus. JF1 carries the piebald allele, a retroposon-like insertion in intron 1 of the endothelin receptor type B (Ednrb) gene, which results in a white coat with black spots and black eyes. The white areas of the coat are lacking in neural crest-derived melanocytes. In addition to alterations in coat color, JF1 mice exhibit a decreased amount of enteric innervation and neuronal density predominantly in the distal colon, but do not exhibit any of the megacolon symptoms often associated with mutations in Ednrb. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (<a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48351102-48351202;v=rs108080490;vdb=variation;vf=14473644">rs108080490</a> and <a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48350652-48351652;v=rs107649577;vdb=variation;vf=14110567">rs107649577</a>; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).

Use of MICE requires an agreement prior to shipping.

This strain is currently unavailable due to replenishing of cryopreserved stocks.&nbsp; Interested customers can register interest.JF1/Ms (Japanese Fancy Mouse) was derived from a fancy mouse stock, and has been identifed as belonging to species M. m. molossinus. JF1 is homozygous for the the piebald allele (Ednrbs). Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Not available for ordering yet; register interest to be informed of changes in availability or <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/contact-technical-support-form">Contact Technical Support</a> for more information.