Project measure / variable:   Schoonjans1   THDCA_plasma_t0_HFD

ID, description, units MPD:112675   THDCA_plasma_t0_HFD   plasma bile acid taurohyodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min   [ng/mL]  HFD  
high-fat diet study
Data set, strains Schoonjans1   BXD w/par   36 strains     sex: m     age: 20wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Schoonjans1 - plasma bile acid taurohyodeoxycholic acid amount, glucose kinetic test, at 20 wks of age, at 0 min HFD



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested36 strains
Mean of the strain means10.986   ng/mL
Median of the strain means8.7862   ng/mL
SD of the strain means± 7.9959
Coefficient of variation (CV)0.7278
Min–max range of strain means0.844   –   32.29   ng/mL
Mean sample size per strain4.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 35 10047.0809 287.0595 1.8212 0.0093
Residuals 118 18599.4347 157.6223


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
BXD1 m 3.5906 0.82865   5 0.37058 0.2308 2.452, 4.65 -0.92
BXD100 m 3.5665 4.9167   8 1.7383 1.3786 0.172, 15.218 -0.93
BXD11 m 4.567 2.6347   2   1.863 0.5769 2.704, 6.43 -0.8
BXD12 m 13.975 10.786   3 6.2274 0.7718 2.828, 24.36 0.37
BXD27 m 3.6868 2.9311   5 1.3108 0.795 1.118, 8.404 -0.91
BXD32 m 0.844 0.48637   4 0.24318 0.5763 0.16, 1.274 -1.27
BXD34 m 5.61 6.293   4 3.1465 1.1217 2.166, 15.038 -0.67
BXD39 m 25.56 34.649   3 20.005 1.3556 3.414, 65.49 1.82
BXD40 m 13.309 2.5932   4 1.2966 0.1948 10.96, 16.414 0.29
BXD43 m 1.0856 0.84118   5 0.37619 0.7749 0.236, 2.17 -1.24
BXD45 m 5.6524 2.095   5 0.93693 0.3706 3.378, 7.982 -0.67
BXD48 m 22.097 11.978   5 5.3567 0.5421 7.286, 39.224 1.39
BXD48a m 23.887 22.253   4 11.126 0.9316 2.682, 53.45 1.61
BXD49 m 6.436 3.7065   5 1.6576 0.5759 2.112, 12.032 -0.57
BXD51 m 11.705 4.468   3 2.5796 0.3817 6.806, 15.556 0.09
BXD53 m 12.487 5.718   5 2.5571 0.4579 6.54, 21.302 0.19
BXD55 m 2.024 0.67485   5 0.3018 0.3334 1.302, 2.902 -1.12
BXD6 m 23.136 46.564   5 20.824 2.0126 1.3647, 106.4 1.52
BXD62 m 1.2845 0.62961   4 0.31481 0.4902 0.482, 1.996 -1.21
BXD63 m 24.258 10.488   5 4.6904 0.4324 8.972, 35.326 1.66
BXD64 m 10.62 6.7077   5 2.9998 0.6316 2.21, 17.906 -0.05
BXD66 m 11.906 6.1739   3 3.5645 0.5185 8.13, 19.031 0.12
BXD67 m 9.3052 8.7695   5 3.9218 0.9424 2.75, 24.41 -0.21
BXD69 m 7.9385 5.0391   4 2.5195 0.6348 2.546, 14.724 -0.38
BXD73 m 4.578 2.45   3 1.4145 0.5352 2.13, 7.03 -0.8
BXD75 m 16.39 9.1494   4 4.5747 0.5582 3.02, 22.858 0.68
BXD77 m 8.2672 7.3446   5 3.2846 0.8884 1.408, 20.148 -0.34
BXD79 m 14.564 9.422   5 4.2137 0.647 1.52, 26.528 0.45
BXD8 m 7.358 6.2621   2   4.428 0.8511 2.93, 11.786 -0.45
BXD81 m 17.753 10.446   5 4.6717 0.5884 6.636, 31.426 0.85
BXD84 m 32.29 22.258   5 9.9539 0.6893 20.418, 71.97 2.66
BXD87 m 5.3475 5.4592   4 2.7296 1.0209 0.188, 10.584 -0.71
BXD89 m 10.836 3.6383   5 1.6271 0.3357 7.266, 16.88 -0.02
BXD90 m 5.545 2.2296   4 1.1148 0.4021 2.636, 7.75 -0.68
C57BL/6J m 17.359 5.5745   3 3.2185 0.3211 11.83, 22.978 0.8
DBA/2J m 6.6787 4.5117   3 2.6048 0.6755 1.65, 10.372 -0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
BXD1 m 3.5906 5.6146652274 14.7091657388 -7.5279657388
BXD100 m 3.5665 4.4387826045 12.3564980123 -5.2234980123
BXD11 m 4.567 8.877565209 22.1469960245 -13.0129960245
BXD12 m 13.9746666667 7.2485016401 28.3286733134 -0.3793399801
BXD27 m 3.6868 5.6146652274 14.8053657388 -7.4317657388
BXD32 m 0.844 6.2773865597 13.2749344022 -11.5869344022
BXD34 m 5.61 6.2773865597 18.0409344022 -6.8209344022
BXD39 m 25.56 7.2485016401 39.9140066467 11.2059933533
BXD40 m 13.3095 6.2773865597 25.7404344022 0.8785655978
BXD43 m 1.0856 5.6146652274 12.2041657388 -10.0329657388
BXD45 m 5.6524 5.6146652274 16.7709657388 -5.4661657388
BXD48 m 22.0972 5.6146652274 33.2157657388 10.9786342612
BXD48a m 23.8875 6.2773865597 36.3184344022 11.4565655978
BXD49 m 6.436 5.6146652274 17.5545657388 -4.6825657388
BXD51 m 11.7046666667 7.2485016401 26.0586733134 -2.6493399801
BXD53 m 12.4872 5.6146652274 23.6057657388 1.3686342612
BXD55 m 2.024 5.6146652274 13.1425657388 -9.0945657388
BXD6 m 23.136 5.6146652274 34.2545657388 12.0174342612
BXD62 m 1.2845 6.2773865597 13.7154344022 -11.1464344022
BXD63 m 24.2576 5.6146652274 35.3761657388 13.1390342612
BXD64 m 10.6204 5.6146652274 21.7389657388 -0.4981657388
BXD66 m 11.9063333333 7.2485016401 26.2603399801 -2.4476733134
BXD67 m 9.3052 5.6146652274 20.4237657388 -1.8133657388
BXD69 m 7.9385 6.2773865597 20.3694344022 -4.4924344022
BXD73 m 4.578 7.2485016401 18.9320066467 -9.7760066467
BXD75 m 16.3905 6.2773865597 28.8214344022 3.9595655978
BXD77 m 8.2672 5.6146652274 19.3857657388 -2.8513657388
BXD79 m 14.5636 5.6146652274 25.6821657388 3.4450342612
BXD8 m 7.358 8.877565209 24.9379960245 -10.2219960245
BXD81 m 17.7528 5.6146652274 28.8713657388 6.6342342612
BXD84 m 32.29 5.6146652274 43.4085657388 21.1714342612
BXD87 m 5.3475 6.2773865597 17.7784344022 -7.0834344022
BXD89 m 10.8364 5.6146652274 21.9549657388 -0.2821657388
BXD90 m 5.545 6.2773865597 17.9759344022 -6.8859344022
C57BL/6J m 17.3593333333 7.2485016401 31.7133399801 3.0053266866
DBA/2J m 6.6786666667 7.2485016401 21.0326733134 -7.6753399801




  GWAS USING LINEAR MIXED MODELS