MPD: Measures involving high-fat high-sucrose diet

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Attie2:14	Attie2	colony observation	high-fat high-sucrose diet	number of days on diet [n] diet_days 110631	DO population		both	4-26wks	N=242	2018

Attie2:15	Attie2	body weight	high-fat high-sucrose diet	body weight after diet [g] bw 110632 wk: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22	DO population		both	5-26wks	N=250	2018

Attie2:37	Attie2	body weight	high-fat high-sucrose diet	change in body weight after diet (compared to wk 1) [g] bw_chg 110654 wk: 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17	DO population		both	6-21wks	N=250	2018

Attie2:53	Attie2	body weight	high-fat high-sucrose diet	change in body weight after diet (compared to wk 10), wk 17 [g] bw_chg_wk17v10 110670	DO population		both	21wks	N=236	2018

Attie2:54	Attie2	intake monitoring	high-fat high-sucrose diet	food consumption after diet [g] food 110671 wk: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21	DO population		both	5-25wks	N=250	2018

Attie2:75	Attie2	intake monitoring	high-fat high-sucrose diet	food consumption average after diet (1 to 21 wks) [g] food_ave 110692	DO population		both	5-25wks	N=250	2018

Attie2:76	Attie2	metabolic panel	high-fat high-sucrose diet	plasma glucose after diet (4h fast) [mg/dL] GLU 110693 wk: 6 10 14 22	DO population		both	10-26wks	N=250	2018

Attie2:80	Attie2	hormone quantification	high-fat high-sucrose diet	plasma insulin after diet (4h fast) [ng/mL] INS 110697 wk: 6 10 14 22	DO population		both	10-26wks	N=250	2018

Attie2:84	Attie2	lipid profile	high-fat high-sucrose diet	plasma triglyceride after diet (4h fast) [mg/dL] TG 110701 wk: 6 10 14 22	DO population		both	10-26wks	N=250	2018

Attie2:88	Attie2	body weight	high-fat high-sucrose diet	body weight at time of oral glucose tolerance test (~14 wks on diet) [g] bw_oGTT 110705	DO population		both	18wks	N=248	2018

Attie2:89	Attie2	glucose tolerance	high-fat high-sucrose diet	glucose level at t=0 after ~14 wks on diet (4h fast) [mg/dL] GLU_0min 110706	DO population		both	18wks	N=248	2018

Attie2:90	Attie2	glucose tolerance	high-fat high-sucrose diet	insulin level at t=0 after ~14 wks on diet (4h fast) [ng/mL] INS_0min 110707	DO population		both	18wks	N=248	2018

Attie2:91	Attie2	glucose tolerance	high-fat high-sucrose diet	HOMA-IR: (glucose x insulin) / 405 at t=0 after ~14 wks on diet (4h fast) HOMA_IR 110708	DO population		both	18wks	N=248	2018

Attie2:92	Attie2	glucose tolerance	high-fat high-sucrose diet	HOMA-B: (360 x insulin) / (glucose minus 63) at t=0 after ~14 wks on diet (4h fast) HOMA_B 110709	DO population		both	18wks	N=246	2018

Attie2:93	Attie2	glucose tolerance	high-fat high-sucrose diet	glucose area under curve (AUC) after ~14 wks on diet without correction for baseline difference (4h fast) [AUC] GLU_AUC_tot 110710	DO population		both	18wks	N=248	2018

Attie2:94	Attie2	glucose tolerance	high-fat high-sucrose diet	glucose area under curve (AUC) after ~14 wks on diet after subtraction of glucose at t=0 (4h fast) [AUC] GLU_AUC_adj 110711	DO population		both	18wks	N=248	2018

Attie2:95	Attie2	glucose tolerance	high-fat high-sucrose diet	insulin area under curve (AUC) after ~14 wks on diet without correction for baseline difference (4h fast) [AUC] INS_AUC_tot 110712	DO population		both	18wks	N=248	2018

Attie2:96	Attie2	glucose tolerance	high-fat high-sucrose diet	insulin area under curve (AUC) after ~14 wks on diet after subtraction of insulin at t=0 (4h fast) [AUC] INS_AUC_adj 110713	DO population		both	18wks	N=248	2018

Attie2:97	Attie2	hormone quantification	high-fat high-sucrose diet	plasma adiponectin measured at the time oral glucose tolerance test performed after ~14 wks on diet (4h fast) [µg/mL] adiponectin 110714	DO population		both	18wks	N=144	2018

Attie2:98	Attie2	hormone quantification	high-fat high-sucrose diet	plasma leptin measured at the time oral glucose tolerance test performed after ~14 wks on diet (4h fast) [ng/mL] leptin 110715	DO population		both	18wks	N=96	2018

Attie2:99	Attie2	microscopy	high-fat high-sucrose diet	number of islets harvested per mouse after diet [n] islets 110716	DO population		both	19-26wks	N=242	2018

Attie2:100	Attie2	hormone quantification	high-fat high-sucrose diet	amount of insulin per islet after diet [ng/mL] INS_per_islet 110717	DO population		both	19-26wks	N=241	2018

Attie2:101	Attie2	hormone quantification	high-fat high-sucrose diet	whole pancreas insulin content after diet (insulin content per islet times number of islets) [ng/mL] INS_per_pancreas 110718	DO population		both	19-26wks	N=241	2018

Attie2:102	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to glucose [ng/mL] INS_GLU 110719 3.3 mM 8.3 mM 16.7 mM	DO population		both	19-26wks	N=242	2018

Attie2:105	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl [ng/mL] INS_GLU3p3_KCl 110722	DO population		both	19-26wks	N=240	2018

Attie2:106	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1 [ng/mL] INS_GLU8p3_GLP1 110723	DO population		both	19-26wks	N=240	2018

Attie2:107	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu) [ng/mL] INS_GLU8p3_AA 110724	DO population		both	19-26wks	N=240	2018

Attie2:108	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid [ng/mL] INS_GLU16p7_PA 110725	DO population		both	19-26wks	N=240	2018

Attie2:109	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_fc_G3p3 110726	DO population		both	19-26wks	N=240	2018

Attie2:110	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose, expressed as fold-change over that observed with 3.3.mM glucose [ratio] INS_GLU16p7_fc_G3p3 110727	DO population		both	19-26wks	N=240	2018

Attie2:111	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU3p3__KCl_fc_G3p3 110728	DO population		both	19-26wks	N=240	2018

Attie2:112	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_GLP1_fc_G3p3 110729	DO population		both	19-26wks	N=240	2018

Attie2:113	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_AA_fc_G3p3 110730	DO population		both	19-26wks	N=240	2018

Attie2:114	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose plus palmitic acid, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU16p7_PA_fc_G3p3 110731	DO population		both	19-26wks	N=240	2018

Attie2:115	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as fold-change over that observed with 8.3 mM glucose [ratio] INS_GLU8p3_GLP1_fc_G8p3 110732	DO population		both	19-26wks	N=240	2018

Attie2:116	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as fold-change over that observed with 8.3 mM glucose [ratio] INS_GLU8p3_AA_fc_G8p3 110733	DO population		both	19-26wks	N=240	2018

Attie2:117	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid, expressed as fold-change over that observed with 16.7 mM glucose [ratio] INS_GLU16p7_PA_fc_G16p7 110734	DO population		both	19-26wks	N=240	2018

Attie2:118	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to glucose, expressed as a percentage of total insulin per mouse [%] INS_pct_GLU 110735 3.3 mM 8.3 mM 16.7 mM	DO population		both	19-26wks	N=241	2018

Attie2:121	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as a percentage of total insulin per mouse [%] INS_GLU3p3_KCl_pct 110738	DO population		both	19-26wks	N=239	2018

Attie2:122	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1, expressed as a percentage of total insulin per mouse [%] INS_GLU8p3_GLP1_pct 110739	DO population		both	19-26wks	N=239	2018

Attie2:123	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as a percentage of total insulin per mouse [%] INS_GLU8p3_AA_pct 110740	DO population		both	19-26wks	N=239	2018

Attie2:124	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid, expressed as a percentage of total insulin per mouse [%] INS_GLU16p7_PA_pct 110741	DO population		both	19-26wks	N=239	2018

Attie2:125	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to glucose (geometric mean) [ng/mL] INS_gm_GLU 110742 3.3 mM 8.3 mM 16.7 mM	DO population		both	19-26wks	N=242	2018

Attie2:128	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl (geometric mean) [ng/mL] INS_gm_GLU3p3_KCl 110745	DO population		both	19-26wks	N=240	2018

Attie2:129	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1 (geometric mean) [ng/mL] INS_gm_GLU8p3_GLP1 110746	DO population		both	19-26wks	N=240	2018

Attie2:130	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu) (geometric mean) [ng/mL] INS_gm_GLU8p3_AA 110747	DO population		both	19-26wks	N=240	2018

Attie2:131	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid (geometric mean) [ng/mL] INS_gm_GLU16p7_PA 110748	DO population		both	19-26wks	N=240	2018

Attie2:132	Attie2	hormone quantification	high-fat high-sucrose diet	amount of glucagon per islet after diet [ng/mL] GCG_per_islet 110749	DO population		both	19-26wks	N=241	2018

Attie2:133	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo glucagon secretion after diet in response to 3.3 mM glucose plus 40 mM KCl [ng/mL] GCG_GLU3p3_KCl 110750	DO population		both	19-26wks	N=182	2018

Attie2:134	Attie2	hormone quantification	high-fat high-sucrose diet	ex vivo glucagon secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as a percentage of total glucagon per mouse [%] GCG_GLU3p3_KCl_pct 110751	DO population		both	19-26wks	N=182	2018

Attie2:135	Attie2	DXA	high-fat high-sucrose diet	tibia bone mineral density (on isolated bone) after diet [g/cm²] BMD 110752	DO population		both	19-26wks	N=241	2018

Attie2:136	Attie2	organ weights	high-fat high-sucrose diet	heart weight after diet [g] heart_wt 110753	DO population		both	19-26wks	N=194	2018

Attie2:137	Attie2	organ weights	high-fat high-sucrose diet	liver left lobe weight after diet [g] liver_wt_L 110754	DO population		both	19-26wks	N=194	2018

Attie2:138	Attie2	organ weights	high-fat high-sucrose diet	liver weight minus left lobe after diet [g] liver_wt_remain 110755	DO population		both	19-26wks	N=194	2018

Attie2:139	Attie2	organ weights	high-fat high-sucrose diet	liver weight total after diet [g] liver_wt_tot 110756	DO population		both	19-26wks	N=194	2018

Attie2:140	Attie2	organ weights	high-fat high-sucrose diet	gonadal fat pad weight after diet [g] gonadal_wt 110757 left right	DO population		both	19-26wks	N=194	2018

Attie2:142	Attie2	organ weights	high-fat high-sucrose diet	gonadal fat pad weight after diet, total [g] gonadal_wt_tot 110759	DO population		both	19-26wks	N=194	2018

Attie2:143	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid deoxycholate in feces after diet (per mg feces) [nmol/mg] DCA 110760	DO population		both	19-26wks	N=48	2018

Attie2:144	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid alpha-muricholate in feces after diet (per mg feces) [nmol/mg] aMCA 110761	DO population		both	19-26wks	N=48	2018

Attie2:145	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid beta-muricholate in feces after diet (per mg feces) [nmol/mg] bMCA 110762	DO population		both	19-26wks	N=48	2018

Attie2:146	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid cholate in feces after diet (per mg feces) [nmol/mg] CA 110763	DO population		both	19-26wks	N=48	2018

Attie2:147	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid glycolithocholate in feces after diet (per mg feces) [nmol/mg] GLiCA 110764	DO population		both	19-26wks	N=48	2018

Attie2:148	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid glycochenodeoxycholate in feces after diet (per mg feces) [nmol/mg] GChDCA 110765	DO population		both	19-26wks	N=48	2018

Attie2:149	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid glycoursodeoxycholate in feces after diet (per mg feces) [nmol/mg] GUDCA 110766	DO population		both	19-26wks	N=48	2018

Attie2:150	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid glycodeoxycholate in feces after diet (per mg feces) [nmol/mg] GDCA 110767	DO population		both	19-26wks	N=48	2018

Attie2:151	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid glycocholate in feces after diet (per mg feces) [nmol/mg] GCA 110768	DO population		both	19-26wks	N=48	2018

Attie2:152	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid taurolithocholate in feces after diet (per mg feces) [nmol/mg] TLiCA 110769	DO population		both	19-26wks	N=47	2018

Attie2:153	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid taurohyodeoxycholate in feces after diet (per mg feces) [nmol/mg] THDCA 110770	DO population		both	19-26wks	N=48	2018

Attie2:154	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid tauroursodeoxycholate in feces after diet (per mg feces) [nmol/mg] TUDCA 110771	DO population		both	19-26wks	N=48	2018

Attie2:155	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid taurochenodeoxycholate in feces after diet (per mg feces) [nmol/mg] TChDCA 110772	DO population		both	19-26wks	N=48	2018

Attie2:156	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid taurodeoxycholate in feces after diet (per mg feces) [nmol/mg] TDCA 110773	DO population		both	19-26wks	N=48	2018

Attie2:157	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid taurocholate in feces after diet (per mg feces) [nmol/mg] TCA 110774	DO population		both	19-26wks	N=48	2018

Attie2:158	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid tauro-alpha-muricholate in feces after diet (per mg feces) [nmol/mg] TaMCA 110775	DO population		both	19-26wks	N=48	2018

Attie2:159	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid tauro-beta-muricholate in feces after diet (per mg feces) [nmol/mg] TbMCA 110776	DO population		both	19-26wks	N=48	2018

Attie2:160	Attie2	biomarker quantification	high-fat high-sucrose diet	bile acid chenodeoxycholate in feces after diet (per mg feces) [nmol/mg] ChDCA 110777	DO population		both	19-26wks	N=48	2018

Attie2:161	Attie2	biomarker quantification	high-fat high-sucrose diet	total bile acid in feces after diet (per mg feces) [nmol/mg] bile_acid_total 110778	DO population		both	19-26wks	N=48	2018

Nadeau2:1	Nadeau2	body size and weight	high-fat high-sucrose diet	body weight [g] bw 53001 baseline after 16wks on diet Δchange	B6.A consomic w/par	24	m	5wks	N=39	2015

Nadeau2:11	Nadeau2	body size and weight	high-fat high-sucrose diet	body length [cm] body_length 53011	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:12	Nadeau2	body size and weight	high-fat high-sucrose diet	body mass index (BMI) [g/cm²] BMI 53012	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:21	Nadeau2	metabolic panel	high-fat high-sucrose diet	glucose (blood GLU, 16h fast) [mmol/L] GLU 53021	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:22	Nadeau2	hormone quantification	high-fat high-sucrose diet	insulin (plasma, 16h fast) [pmol/L] INS 53022	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:23	Nadeau2	hormone quantification	high-fat high-sucrose diet	homeostasis model assessment insulin resistance (HOMA-IR, 16h fast) HOMA_IR 53023	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:41	Nadeau2	lipid profile	high-fat high-sucrose diet	total cholesterol (plasma CHOL) [mmol/L] CHOL 53041	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:42	Nadeau2	lipid profile	high-fat high-sucrose diet	triglycerides (plasma TG, 16h fast) [mmol/L] TG 53042	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:51	Nadeau2	organ weights	high-fat high-sucrose diet	liver weight [g] liver_wt 53051	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:52	Nadeau2	lipid profile	high-fat high-sucrose diet	liver triglycerides (mg/g liver) liver_TG 53052	B6.A consomic w/par	24	m	21wks	N=39	2015

Nadeau2:53	Nadeau2	lipid profile	high-fat high-sucrose diet	total liver triglycerides [g] liver_TG_tot 53053	B6.A consomic w/par	24	m	21wks	N=39	2015

Attie2

colony observation

high-fat high-sucrose diet

number of days on diet [n] diet_days 110631

DO population

both

4-26wks

N=242

2018

Attie2

body weight

high-fat high-sucrose diet

body weight after diet [g] bw 110632 wk: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22

DO population

both

5-26wks

N=250

2018

Attie2

body weight

high-fat high-sucrose diet

change in body weight after diet (compared to wk 1) [g] bw_chg 110654 wk: 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

DO population

both

6-21wks

N=250

2018

Attie2

body weight

high-fat high-sucrose diet

change in body weight after diet (compared to wk 10), wk 17 [g] bw_chg_wk17v10 110670

DO population

both

21wks

N=236

2018

Attie2

intake monitoring

high-fat high-sucrose diet

food consumption after diet [g] food 110671 wk: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

DO population

both

5-25wks

N=250

2018

Attie2

intake monitoring

high-fat high-sucrose diet

food consumption average after diet (1 to 21 wks) [g] food_ave 110692

DO population

both

5-25wks

N=250

2018

Attie2

metabolic panel

high-fat high-sucrose diet

plasma glucose after diet (4h fast) [mg/dL] GLU 110693 wk: 6 10 14 22

DO population

both

10-26wks

N=250

2018

Attie2

hormone quantification

high-fat high-sucrose diet

plasma insulin after diet (4h fast) [ng/mL] INS 110697 wk: 6 10 14 22

DO population

both

10-26wks

N=250

2018

Attie2

lipid profile

high-fat high-sucrose diet

plasma triglyceride after diet (4h fast) [mg/dL] TG 110701 wk: 6 10 14 22

DO population

both

10-26wks

N=250

2018

Attie2

body weight

high-fat high-sucrose diet

body weight at time of oral glucose tolerance test (~14 wks on diet) [g] bw_oGTT 110705

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

glucose level at t=0 after ~14 wks on diet (4h fast) [mg/dL] GLU_0min 110706

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

insulin level at t=0 after ~14 wks on diet (4h fast) [ng/mL] INS_0min 110707

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

HOMA-IR: (glucose x insulin) / 405 at t=0 after ~14 wks on diet (4h fast) HOMA_IR 110708

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

HOMA-B: (360 x insulin) / (glucose minus 63) at t=0 after ~14 wks on diet (4h fast) HOMA_B 110709

DO population

both

18wks

N=246

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

glucose area under curve (AUC) after ~14 wks on diet without correction for baseline difference (4h fast) [AUC] GLU_AUC_tot 110710

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

glucose area under curve (AUC) after ~14 wks on diet after subtraction of glucose at t=0 (4h fast) [AUC] GLU_AUC_adj 110711

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

insulin area under curve (AUC) after ~14 wks on diet without correction for baseline difference (4h fast) [AUC] INS_AUC_tot 110712

DO population

both

18wks

N=248

2018

Attie2

glucose tolerance

high-fat high-sucrose diet

insulin area under curve (AUC) after ~14 wks on diet after subtraction of insulin at t=0 (4h fast) [AUC] INS_AUC_adj 110713

DO population

both

18wks

N=248

2018

Attie2

hormone quantification

high-fat high-sucrose diet

plasma adiponectin measured at the time oral glucose tolerance test performed after ~14 wks on diet (4h fast) [µg/mL] adiponectin 110714

DO population

both

18wks

N=144

2018

Attie2

hormone quantification

high-fat high-sucrose diet

plasma leptin measured at the time oral glucose tolerance test performed after ~14 wks on diet (4h fast) [ng/mL] leptin 110715

DO population

both

18wks

N=96

2018

Attie2

microscopy

high-fat high-sucrose diet

number of islets harvested per mouse after diet [n] islets 110716

DO population

both

19-26wks

N=242

2018

Attie2

hormone quantification

high-fat high-sucrose diet

amount of insulin per islet after diet [ng/mL] INS_per_islet 110717

DO population

both

19-26wks

N=241

2018

Attie2

hormone quantification

high-fat high-sucrose diet

whole pancreas insulin content after diet (insulin content per islet times number of islets) [ng/mL] INS_per_pancreas 110718

DO population

both

19-26wks

N=241

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to glucose [ng/mL] INS_GLU 110719 3.3 mM 8.3 mM 16.7 mM

DO population

both

19-26wks

N=242

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl [ng/mL] INS_GLU3p3_KCl 110722

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1 [ng/mL] INS_GLU8p3_GLP1 110723

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu) [ng/mL] INS_GLU8p3_AA 110724

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid [ng/mL] INS_GLU16p7_PA 110725

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_fc_G3p3 110726

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose, expressed as fold-change over that observed with 3.3.mM glucose [ratio] INS_GLU16p7_fc_G3p3 110727

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU3p3__KCl_fc_G3p3 110728

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_GLP1_fc_G3p3 110729

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU8p3_AA_fc_G3p3 110730

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose plus palmitic acid, expressed as fold-change over that observed with 3.3 mM glucose [ratio] INS_GLU16p7_PA_fc_G3p3 110731

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as fold-change over that observed with 8.3 mM glucose [ratio] INS_GLU8p3_GLP1_fc_G8p3 110732

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as fold-change over that observed with 8.3 mM glucose [ratio] INS_GLU8p3_AA_fc_G8p3 110733

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid, expressed as fold-change over that observed with 16.7 mM glucose [ratio] INS_GLU16p7_PA_fc_G16p7 110734

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to glucose, expressed as a percentage of total insulin per mouse [%] INS_pct_GLU 110735 3.3 mM 8.3 mM 16.7 mM

DO population

both

19-26wks

N=241

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as a percentage of total insulin per mouse [%] INS_GLU3p3_KCl_pct 110738

DO population

both

19-26wks

N=239

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1, expressed as a percentage of total insulin per mouse [%] INS_GLU8p3_GLP1_pct 110739

DO population

both

19-26wks

N=239

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu), expressed as a percentage of total insulin per mouse [%] INS_GLU8p3_AA_pct 110740

DO population

both

19-26wks

N=239

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid, expressed as a percentage of total insulin per mouse [%] INS_GLU16p7_PA_pct 110741

DO population

both

19-26wks

N=239

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to glucose (geometric mean) [ng/mL] INS_gm_GLU 110742 3.3 mM 8.3 mM 16.7 mM

DO population

both

19-26wks

N=242

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 3.3 mM glucose plus 40 mM KCl (geometric mean) [ng/mL] INS_gm_GLU3p3_KCl 110745

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus 100 nM GLP-1 (geometric mean) [ng/mL] INS_gm_GLU8p3_GLP1 110746

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 8.3 mM glucose plus a mix of amino acids (Ala, Glu, Leu) (geometric mean) [ng/mL] INS_gm_GLU8p3_AA 110747

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo insulin secretion after diet in response to 16.7 mM glucose plus 0.5 mM palmitic acid (geometric mean) [ng/mL] INS_gm_GLU16p7_PA 110748

DO population

both

19-26wks

N=240

2018

Attie2

hormone quantification

high-fat high-sucrose diet

amount of glucagon per islet after diet [ng/mL] GCG_per_islet 110749

DO population

both

19-26wks

N=241

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo glucagon secretion after diet in response to 3.3 mM glucose plus 40 mM KCl [ng/mL] GCG_GLU3p3_KCl 110750

DO population

both

19-26wks

N=182

2018

Attie2

hormone quantification

high-fat high-sucrose diet

ex vivo glucagon secretion after diet in response to 3.3 mM glucose plus 40 mM KCl, expressed as a percentage of total glucagon per mouse [%] GCG_GLU3p3_KCl_pct 110751

DO population

both

19-26wks

N=182

2018

Attie2

DXA

high-fat high-sucrose diet

tibia bone mineral density (on isolated bone) after diet [g/cm²] BMD 110752

DO population

both

19-26wks

N=241

2018

Attie2

organ weights

high-fat high-sucrose diet

heart weight after diet [g] heart_wt 110753

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

liver left lobe weight after diet [g] liver_wt_L 110754

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

liver weight minus left lobe after diet [g] liver_wt_remain 110755

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

liver weight total after diet [g] liver_wt_tot 110756

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

gonadal fat pad weight after diet [g] gonadal_wt 110757 left right

DO population

both

19-26wks

N=194

2018

Attie2

organ weights

high-fat high-sucrose diet

gonadal fat pad weight after diet, total [g] gonadal_wt_tot 110759

DO population

both

19-26wks

N=194

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid deoxycholate in feces after diet (per mg feces) [nmol/mg] DCA 110760

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid alpha-muricholate in feces after diet (per mg feces) [nmol/mg] aMCA 110761

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid beta-muricholate in feces after diet (per mg feces) [nmol/mg] bMCA 110762

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid cholate in feces after diet (per mg feces) [nmol/mg] CA 110763

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid glycolithocholate in feces after diet (per mg feces) [nmol/mg] GLiCA 110764

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid glycochenodeoxycholate in feces after diet (per mg feces) [nmol/mg] GChDCA 110765

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid glycoursodeoxycholate in feces after diet (per mg feces) [nmol/mg] GUDCA 110766

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid glycodeoxycholate in feces after diet (per mg feces) [nmol/mg] GDCA 110767

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid glycocholate in feces after diet (per mg feces) [nmol/mg] GCA 110768

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid taurolithocholate in feces after diet (per mg feces) [nmol/mg] TLiCA 110769

DO population

both

19-26wks

N=47

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid taurohyodeoxycholate in feces after diet (per mg feces) [nmol/mg] THDCA 110770

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid tauroursodeoxycholate in feces after diet (per mg feces) [nmol/mg] TUDCA 110771

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid taurochenodeoxycholate in feces after diet (per mg feces) [nmol/mg] TChDCA 110772

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid taurodeoxycholate in feces after diet (per mg feces) [nmol/mg] TDCA 110773

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid taurocholate in feces after diet (per mg feces) [nmol/mg] TCA 110774

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid tauro-alpha-muricholate in feces after diet (per mg feces) [nmol/mg] TaMCA 110775

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid tauro-beta-muricholate in feces after diet (per mg feces) [nmol/mg] TbMCA 110776

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

bile acid chenodeoxycholate in feces after diet (per mg feces) [nmol/mg] ChDCA 110777

DO population

both

19-26wks

N=48

2018

Attie2

biomarker quantification

high-fat high-sucrose diet

total bile acid in feces after diet (per mg feces) [nmol/mg] bile_acid_total 110778

DO population

both

19-26wks

N=48

2018

Nadeau2

body size and weight

high-fat high-sucrose diet

body weight [g] bw 53001 baseline after 16wks on diet Δchange

B6.A consomic w/par

24

m

5wks

N=39

2015

Nadeau2

body size and weight

high-fat high-sucrose diet

body length [cm] body_length 53011

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

body size and weight

high-fat high-sucrose diet

body mass index (BMI) [g/cm²] BMI 53012

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

metabolic panel

high-fat high-sucrose diet

glucose (blood GLU, 16h fast) [mmol/L] GLU 53021

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

hormone quantification

high-fat high-sucrose diet

insulin (plasma, 16h fast) [pmol/L] INS 53022

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

hormone quantification

high-fat high-sucrose diet

homeostasis model assessment insulin resistance (HOMA-IR, 16h fast) HOMA_IR 53023

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

total cholesterol (plasma CHOL) [mmol/L] CHOL 53041

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

triglycerides (plasma TG, 16h fast) [mmol/L] TG 53042

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

organ weights

high-fat high-sucrose diet

liver weight [g] liver_wt 53051

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

liver triglycerides (mg/g liver) liver_TG 53052

B6.A consomic w/par

24

m

21wks

N=39

2015

Nadeau2

lipid profile

high-fat high-sucrose diet

total liver triglycerides [g] liver_TG_tot 53053

B6.A consomic w/par

24

m

21wks

N=39

2015

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