MPD: Measures involving high-fat diet and ethanol

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Rusyn5:1	Rusyn5	metabolic panel	high-fat diet and ethanol	serum alanine transaminase (ALT) [IU/L] ALT 43001 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:3	Rusyn5	metabolite quantification	high-fat diet and ethanol	homocysteine concentration (plasma) [nmol/mL] plasma_homocysteine 43003 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:5	Rusyn5	alcohol quantification	high-fat diet and ethanol	blood alcohol concentration (BAC) [mg/dL] BAC 43005 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:7	Rusyn5	alcohol quantification	high-fat diet and ethanol	urine alcohol concentration (UAC), daily average [mg/dL] avg_UAC 43007 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:9	Rusyn5	alcohol quantification	high-fat diet and ethanol	urine alcohol concentration (UAC), daily peak [mg/dL] peak_UAC 43009 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:11	Rusyn5	organ weights	high-fat diet and ethanol	liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:13	Rusyn5	histopathology	high-fat diet and ethanol	liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:15	Rusyn5	histopathology	high-fat diet and ethanol	liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:17	Rusyn5	histopathology	high-fat diet and ethanol	liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:19	Rusyn5	histopathology	high-fat diet and ethanol	total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:21	Rusyn5	lipid profile	high-fat diet and ethanol	hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol	inbred	6	m	8-14wks	N=3	2011

Rusyn5:23	Rusyn5	metabolite quantification	high-fat diet and ethanol	reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:25	Rusyn5	metabolite quantification	high-fat diet and ethanol	oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:29	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:31	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:33	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:35	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:37	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:39	Rusyn5	metabolite quantification	high-fat diet and ethanol	ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Rusyn5:42	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042	inbred	14	m	8-14wks	N=3	2011

Rusyn5:44	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044	inbred	14	m	8-14wks	N=3	2011

Rusyn5:46	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046	inbred	14	m	8-14wks	N=3	2011

Rusyn5:48	Rusyn5	metabolite quantification	high-fat diet and ethanol	liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048	inbred	14	m	8-14wks	N=3	2011

Rusyn5:50	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050	inbred	6	m	8-14wks	N=3	2011

Rusyn5:52	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052	inbred	6	m	8-14wks	N=3	2011

Rusyn5:54	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054	inbred	14	m	8-14wks	N=3	2011

Rusyn5:56	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056	inbred	14	m	8-14wks	N=3	2011

Rusyn5:58	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058	inbred	14	m	8-14wks	N=3	2011

Rusyn5:60	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060	inbred	14	m	8-14wks	N=3	2011

Rusyn5:62	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062	inbred	14	m	8-14wks	N=3	2011

Rusyn5:64	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064	inbred	14	m	8-14wks	N=3	2011

Rusyn5:66	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066	inbred	14	m	8-14wks	N=3	2011

Rusyn5:68	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068	inbred	14	m	8-14wks	N=3	2011

Rusyn5:70	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070	inbred	14	m	8-14wks	N=3	2011

Rusyn5:72	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072	inbred	6	m	8-14wks	N=3	2011

Rusyn5:74	Rusyn5	RNA expression profiling	high-fat diet and ethanol	liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074	inbred	14	m	8-14wks	N=3	2011

Rusyn5

metabolic panel

high-fat diet and ethanol

serum alanine transaminase (ALT) [IU/L] ALT 43001 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

homocysteine concentration (plasma) [nmol/mL] plasma_homocysteine 43003 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

blood alcohol concentration (BAC) [mg/dL] BAC 43005 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

urine alcohol concentration (UAC), daily average [mg/dL] avg_UAC 43007 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

alcohol quantification

high-fat diet and ethanol

urine alcohol concentration (UAC), daily peak [mg/dL] peak_UAC 43009 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

organ weights

high-fat diet and ethanol

liver weight as a percent of body weight [%] pctLW_BW 43011 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver steatosis (0-4) [score] steatosis 43013 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver inflammation (0-2) [score] inflammation 43015 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

liver necrosis (0-2) [score] necrosis 43017 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

histopathology

high-fat diet and ethanol

total liver histopathology (0-8) [score] total_pathology 43019 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

lipid profile

high-fat diet and ethanol

hepatic triglycerides (TG) [mg/g] liver_TG 43021 high-fat only high-fat and ethanol

inbred

6

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

reduced liver glutathione (GSH) [nmol/mg] liver_GSH 43023 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

oxidized liver glutathione (GSSG) [nmol/mg] liver_GSSG 43025 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of reduced to oxidized liver glutathione [ratio] liver_GSHratio 43029 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver homocysteine [nmol/mg] liver_homocysteine 43031 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylhomocysteine (SAH) [nmol/mg] liver_SAH 43033 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver methionine [nmol/mg] liver_methionine 43035 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver S-adenosylmethionine (SAM) [nmol/mg] liver_SAM 43037 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

ratio of liver SAM to SAH (SAM/SAH) [ratio] liver_SAM_SAH 43039 high-fat only high-fat and ethanol

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver BHMT, protein expression relative to high-fat-only group [%] liver_BHMT_hfe 43042

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver DDIT3 (formerly CHOP), protein expression relative to high-fat-only group [%] liver_DDIT3_hfe 43044

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver HSPA5 (formerly GRP78), protein expression relative to high-fat-only group [%] liver_HSPA5_hfe 43046

inbred

14

m

8-14wks

N=3

2011

Rusyn5

metabolite quantification

high-fat diet and ethanol

liver SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group [%] liver_SREBF1_hfe 43048

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Acox1, mRNA abundance relative to high-fat-only group [%] liver_Acox1_hfe 43050

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Adipor2, mRNA abundance relative to high-fat-only group [%] liver_Adipor2_hfe 43052

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ahcy, mRNA abundance relative to high-fat-only group [%] liver_Ahcy_hfe 43054

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cbs, mRNA abundance relative to high-fat-only group [%] liver_Cbs_hfe 43056

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cebpa, mRNA abundance relative to high-fat-only group [%] liver_Cebpa_hfe 43058

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Cth, mRNA abundance relative to high-fat-only group [%] liver_Cth_hfe 43060

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group [%] liver_Ddit3_hfe 43062

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Gnmt, mRNA abundance relative to high-fat-only group [%] liver_Gnmt_hfe 43064

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mat1a, mRNA abundance relative to high-fat-only group [%] liver_Mat1a_hfe 43066

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mthfr, mRNA abundance relative to high-fat-only group [%] liver_Mthfr_hfe 43068

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mtr, mRNA abundance relative to high-fat-only group [%] liver_Mtr_hfe 43070

inbred

14

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Mttp, mRNA abundance relative to high-fat-only group [%] liver_Mttp_hfe 43072

inbred

6

m

8-14wks

N=3

2011

Rusyn5

RNA expression profiling

high-fat diet and ethanol

liver Srebf1, mRNA abundance relative to high-fat-only group [%] liver_Srebf1_hfe 43074

inbred

14

m

8-14wks

N=3

2011

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