Intervention:   high-fat diet and ethanol

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg) Year
    Rusyn5 43001 metabolic panel high-fat diet and ethanol serum alanine transaminase (ALT)   [IU/L]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43003 metabolite quantification high-fat diet and ethanol homocysteine concentration (plasma)   [nmol/mL]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43005 alcohol quantification high-fat diet and ethanol blood alcohol concentration (BAC)   [mg/dL]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43007 alcohol quantification high-fat diet and ethanol urine alcohol concentration (UAC), daily average   [mg/dL]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43009 alcohol quantification high-fat diet and ethanol urine alcohol concentration (UAC), daily peak   [mg/dL]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43011 organ weights high-fat diet and ethanol liver weight as a percent of body weight   [%]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43013 histopathology high-fat diet and ethanol liver steatosis (0-4)   [score]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43015 histopathology high-fat diet and ethanol liver inflammation (0-2)   [score]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43017 histopathology high-fat diet and ethanol liver necrosis (0-2)   [score]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43019 histopathology high-fat diet and ethanol total liver histopathology (0-8)   [score]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43021 lipid profile high-fat diet and ethanol hepatic triglycerides (TG)   [mg/g]     high-fat only    high-fat and ethanol inbred 6 m 8-14wks N=3 2011
    Rusyn5 43023 metabolite quantification high-fat diet and ethanol reduced liver glutathione (GSH)   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43025 metabolite quantification high-fat diet and ethanol oxidized liver glutathione (GSSG)   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43029 metabolite quantification high-fat diet and ethanol ratio of reduced to oxidized liver glutathione   [ratio]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43031 metabolite quantification high-fat diet and ethanol liver homocysteine   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43033 metabolite quantification high-fat diet and ethanol liver S-adenosylhomocysteine (SAH)   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43035 metabolite quantification high-fat diet and ethanol liver methionine   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43037 metabolite quantification high-fat diet and ethanol liver S-adenosylmethionine (SAM)   [nmol/mg]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43039 metabolite quantification high-fat diet and ethanol ratio of liver SAM to SAH (SAM/SAH)   [ratio]     high-fat only    high-fat and ethanol inbred 14 m 8-14wks N=3 2011
    Rusyn5 43042 metabolite quantification high-fat diet and ethanol BHMT, protein expression relative to high-fat-only group   [%]  liver_BHMT_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43044 metabolite quantification high-fat diet and ethanol DDIT3 (formerly CHOP), protein expression relative to high-fat-only group   [%]  liver_DDIT3_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43046 metabolite quantification high-fat diet and ethanol HSPA5 (formerly GRP78), protein expression relative to high-fat-only group   [%]  liver_HSPA5_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43048 metabolite quantification high-fat diet and ethanol SREBF1 (formerly NSREBP1), protein expression relative to high-fat-only group   [%]  liver_SREBF1_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43050 RNA expression profiling high-fat diet and ethanol Acox1, mRNA abundance relative to high-fat-only group   [%]  liver_Acox1_hfe inbred 6 m 8-14wks N=3 2011
    Rusyn5 43052 RNA expression profiling high-fat diet and ethanol Adipor2, mRNA abundance relative to high-fat-only group   [%]  liver_Adipor2_hfe inbred 6 m 8-14wks N=3 2011
    Rusyn5 43054 RNA expression profiling high-fat diet and ethanol Ahcy, mRNA abundance relative to high-fat-only group   [%]  liver_Ahcy_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43056 RNA expression profiling high-fat diet and ethanol Cbs, mRNA abundance relative to high-fat-only group   [%]  liver_Cbs_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43058 RNA expression profiling high-fat diet and ethanol Cebpa, mRNA abundance relative to high-fat-only group   [%]  liver_Cebpa_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43060 RNA expression profiling high-fat diet and ethanol Cth, mRNA abundance relative to high-fat-only group   [%]  liver_Cth_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43062 RNA expression profiling high-fat diet and ethanol Ddit3 (formerly Chop), mRNA abundance relative to high-fat-only group   [%]  liver_Ddit3_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43064 RNA expression profiling high-fat diet and ethanol Gnmt, mRNA abundance relative to high-fat-only group   [%]  liver_Gnmt_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43066 RNA expression profiling high-fat diet and ethanol Mat1a, mRNA abundance relative to high-fat-only group   [%]  liver_Mat1a_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43068 RNA expression profiling high-fat diet and ethanol Mthfr, mRNA abundance relative to high-fat-only group   [%]  liver_Mthfr_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43070 RNA expression profiling high-fat diet and ethanol Mtr, mRNA abundance relative to high-fat-only group   [%]  liver_Mtr_hfe inbred 14 m 8-14wks N=3 2011
    Rusyn5 43072 RNA expression profiling high-fat diet and ethanol Mttp, mRNA abundance relative to high-fat-only group   [%]  liver_Mttp_hfe inbred 6 m 8-14wks N=3 2011
    Rusyn5 43074 RNA expression profiling high-fat diet and ethanol Srebf1, mRNA abundance relative to high-fat-only group   [%]  liver_Srebf1_hfe inbred 14 m 8-14wks N=3 2011
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