Multi-system analysis of mouse physiology, C57BL/6J-Chr#PWD chromosome substitution strain panel. Purpose: To examine the phenotypic outcome of C57BL/6J-Chr#PWD chromosome substitution for multiple parameters such as hematology, blood chemistry, and body composition.

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains blood chemistry — enzymes   Svenson2   B6.PWD consomic aspartate aminotransferase (plasma AST, SGOT)   [mg/dL] 18 strains   age 8wks   blood chemistry — glucose   Svenson2   B6.PWD consomic glucose (plasma GLU, 4h fast)   [mg/dL] 18 strains   age 8wks   blood chemistry — miscellaneous   Svenson2   B6.PWD consomic total bilirubin (plasma TBIL)   [mg/dL] 17 strains   age 8wks   blood chemistry — proteins — coagulation   Svenson2   B6.PWD consomic clotting factors [% of normal human value]         • AT III        • factor VIII        • fibrinogen        18 strains   age 6wks   blood chemistry — urea nitrogen   Svenson2   B6.PWD consomic blood urea nitrogen (plasma BUN)   [mg/dL] 10 strains   age 8wks   blood hematology — CBC — differentials   Svenson2   B6.PWD consomic cell counts [n/µL]         • WBC        • RBC        18 strains   age 7wks Svenson2   B6.PWD consomic % differentials [%]         • neutrophils        • lymphocytes        • monocytes        • eosinophils        • basophils        • LUC        18 strains   age 7wks Svenson2   B6.PWD consomic differential cell counts [n/µL]         • neutrophils        • lymphocytes        • monocytes        • eosinophils        • basophils        • LUC        18 strains   age 7wks   blood hematology — CBC — platelets   Svenson2   B6.PWD consomic platelet [n/µL]         • PLT count        • MPV        18 strains   age 7wks   blood hematology — CBC — red cell parameters — cell distribution width   Svenson2   B6.PWD consomic RBC corpuscular distribution width (RDW)   [%] 18 strains   age 7wks   blood hematology — CBC — red cell parameters — cell volume   Svenson2   B6.PWD consomic mean RBC corpuscular volume (MCV)   [fL] 18 strains   age 7wks   blood hematology — CBC — red cell parameters — hematocrit   Svenson2   B6.PWD consomic hematocrit (HCT)   [%] 18 strains   age 7wks   blood hematology — CBC — red cell parameters — hemoglobin   Svenson2   B6.PWD consomic hemoglobin         • measured HGB        • calculated HGB        • MCH        • MCHC        • CHCM        • HDW        18 strains   age 7wks   blood hematology — CBC — red cell parameters — reticulocytes   Svenson2   B6.PWD consomic reticulocytes         • count [n/L]        • % of total RBC        18 strains   age 7wks   blood lipids — cholesterol — HDL   Svenson2   B6.PWD consomic high density lipoprotein cholesterol (plasma HDL)   [mg/dL] 18 strains   age 8wks   blood lipids — cholesterol — total   Svenson2   B6.PWD consomic total cholesterol (plasma CHOL)   [mg/dL] 18 strains   age 8wks   blood lipids — fatty acids   Svenson2   B6.PWD consomic free fatty acids (plasma FFA)   [mEq/L] 18 strains   age 8wks   blood lipids — triglycerides   Svenson2   B6.PWD consomic triglycerides (plasma TG)   [mg/dL] 18 strains   age 8wks   body composition — fat — (head excluded)   Svenson2   B6.PWD consomic fat portion of body mass [g]         • fat weight        • % fat        17 strains   age 16wks   body composition — lean — (head excluded)   Svenson2   B6.PWD consomic lean body tissue mass   [g] 15 strains   age 16wks   body composition — total — (head excluded)   Svenson2   B6.PWD consomic total body tissue mass   [g] 17 strains   age 16wks   bone — mineral density and content — whole body (head excluded)   Svenson2   B6.PWD consomic BMD and BMC [g/cm2]         • BMD        • BMC        17 strains   age 16wks Display strain means in the above table for: select a strain B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr12 B6.PWD-Chr14 B6.PWD-Chr16 B6.PWD-Chr17 B6.PWD-Chr18 B6.PWD-Chr19 B6.PWD-Chr2 B6.PWD-Chr5 B6.PWD-Chr6 B6.PWD-Chr9 B6.PWD-ChrMT B6.PWD-ChrX. B6.PWD-ChrX. B6.PWD-ChrY C57BL/6J PWD/PhJ   Compare two strains: select strain 1 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr12 B6.PWD-Chr14 B6.PWD-Chr16 B6.PWD-Chr17 B6.PWD-Chr18 B6.PWD-Chr19 B6.PWD-Chr2 B6.PWD-Chr5 B6.PWD-Chr6 B6.PWD-Chr9 B6.PWD-ChrMT B6.PWD-ChrX. B6.PWD-ChrX. B6.PWD-ChrY C57BL/6J PWD/PhJ vs. select strain 2 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr12 B6.PWD-Chr14 B6.PWD-Chr16 B6.PWD-Chr17 B6.PWD-Chr18 B6.PWD-Chr19 B6.PWD-Chr2 B6.PWD-Chr5 B6.PWD-Chr6 B6.PWD-Chr9 B6.PWD-ChrMT B6.PWD-ChrX. B6.PWD-ChrX. B6.PWD-ChrY C57BL/6J PWD/PhJ   Compare female vs. male for: select a strain B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr11 B6.PWD-Chr12 B6.PWD-Chr14 B6.PWD-Chr16 B6.PWD-Chr17 B6.PWD-Chr18 B6.PWD-Chr19 B6.PWD-Chr2 B6.PWD-Chr5 B6.PWD-Chr6 B6.PWD-Chr9 B6.PWD-ChrMT B6.PWD-ChrX. B6.PWD-ChrX. B6.PWD-ChrY C57BL/6J PWD/PhJ   Display overall measurement averages (all strains combined) in the above table

Notes

Gregorová S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, Donahue LR, Paigen B, Forejt J. Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res. 2008 Mar;18(3):509-15. Epub 2008 Feb 6.     PubMed    MGI There has been one update or correction to the dataset since it was first released in Mar, 2008 Please note. Some strain means have N < 3 animals (click for table). Some measurements were derived by MPD staff, based on supplied data (click for list). This is one of several projects supplied by Heart, Lung, Blood and Sleep Disorders Center. Data collection is ongoing; additional data are expected.

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The Svenson2 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Svenson2 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Svenson2 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Svenson2 protocol document HTML Svenson2 animal documentation HTML Supplemental data None