MPD - Project: Hunter1

Project: Hunter1 (1998)
Investigators & administrative info Publications Downloads & Notes

Transgenic survey: Genetic susceptibility to metastatic progression of a mammary tumor.
Purpose: To identify and characterize primary mammary tumor latency, severity and metastasis in transgene positive (MMTV-PyMT) F1 virgin female progeny of different inbred strains of mice. FVB/N-Tg(MMTV-PyMT)634Mul/J males were bred to females of various inbred strains. F1 transgenic females were analyzed. Primary tumors were noted and confirmed; mice were analyzed after 40 days (aged to permit metastatic progression). Metastases were scored from 9 viewing fields per animal; metastases (number and area) and total lung area are reported as an average over these fields.

Available measurements
Mice & strains Protocol Plots & tools wizard
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cancer — metastatic progression

Hunter1
MMTV PyVT transgenic

mammary tumor latency, days after birth [d]
28 strains

Hunter1
MMTV PyVT transgenic

tumor burden (body weight at sacrifice minus body weight at diagnosis of primary tumor) [g]
28 strains

Hunter1
MMTV PyVT transgenic

number of pulmonary metastases
• number
• per total lung area (x 10^-9)
28 strains

Hunter1
MMTV PyVT transgenic

area of pulmonary metastases
• area (x 10³)
• per number of metastases
• per total lung area
28 strains

Hunter1
MMTV PyVT transgenic

total lung area (x 10³) [µm²]
28 strains

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Display overall measurement averages (all strains combined) in the above table

Notes

Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, Hunter KW. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer. 1998 Aug 12;77(4):640-4. PubMed MGI

There have been no updates or corrections to the dataset since it was first released in May, 2001
More information about the tested strains.
Please note. Some strain means have N < 3 animals (click for table).

Downloads Help

The Hunter1 project data set.
Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file

Hunter1 individual animal data in list format.
Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file

Hunter1 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file

These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above.

Hunter1 protocol document HTML

Hunter1 animal documentation HTML

Supplemental data None

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