Ethanol sensitivity. Two tests of motor incoordination were used to measure ethanol intoxication in 8 inbred strains. Missteps, limb dragging, and hanging/falling were recorded for balance beam testing in groups of mice subjected to saline (baseline) or one of three doses of ethanol. Misstep data are adjusted to baseline data and are available for analysis. The grid test was conducted on 4 consecutive days; days 1-3 for habituation (saline only) and day 4 for one of three doses of ethanol. Day 3 and day 4 data are available for analysis.

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains behavior — activity and motor function &ndash balance beam   Crabbe1 missteps crossing balance beam [n]     control and  EtOH         12.7mm beam:   • control      i.p. doses:   • 1.0g/kg     • 1.2g/kg     • 1.4g/kg    EtOH dose effect comparison           15.8mm beam:   • control      i.p. doses:   • 1.0g/kg     • 1.2g/kg     • 1.4g/kg    EtOH dose effect comparison           19.0mm beam:   • control      i.p. doses:   • 1.0g/kg     • 1.2g/kg     • 1.4g/kg    EtOH dose effect comparison           compare by beam width:   control 0     1.0g/kg     1.2g/kg     1.4g/kg  8 strains   age 8-16wks   behavior — activity and motor function &ndash grid test   Crabbe1 grid habituation, distance traveled [cm]     control and  EtOH       • control    i.p. doses: • 1.5g/kg   • 2.0g/kg   • 2.5g/kg    EtOH dose effect comparison   8 strains   age 8-16wks Crabbe1 grid habituation, missteps per cm [n/cm]     control and  EtOH       • control    i.p. doses: • 1.5g/kg   • 2.0g/kg   • 2.5g/kg    EtOH dose effect comparison   8 strains   age 8-16wks   body weight   Crabbe1 body weight   [g] 8 strains   age 8-16wks   local experiment parameter   Crabbe1 age   [days] 8 strains   age 8-16wks Display strain means in the above table for: select a strain 129S1/SvImJ A/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Compare two strains: select strain 1 129S1/SvImJ A/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ vs. select strain 2 129S1/SvImJ A/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Compare female vs. male for: select a strain 129S1/SvImJ A/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Display overall measurement averages (all strains combined) in the above table

Notes

Crabbe JC, Metten P, Yu CH, Schlumbohm JP, Cameron AJ, Wahlsten D. Genotypic Differences in Ethanol Sensitivity in Two Tests of Motor Incoordination. J Appl Physiol. 2003 Oct;95(4):1338-51. Epub 2003 Apr 18.     PubMed    MGI There have been 2 updates or corrections to the dataset since it was first released in Nov, 2003 Care should be exercised if using these data in individual animal scatterplots; some measurement combinations have few or no animals in common. The investigator selected the most useful measurements for MPD accessioning. Supplemental data (available below) include scores for hanging or falling from the balance beam, raw misstep data, and grid data from 5-min intervals. Please note. Some strain means have N < 3 animals (click for table).

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The Crabbe1 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Crabbe1 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Crabbe1 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Crabbe1 protocol document HTML Crabbe1 animal documentation HTML Supplemental data are available Click here for more info