Diet effects on plasma lipids and susceptibility to atherosclerosis (pathogen-free conditions). Data are available for mice on a 6% fat diet (LabDiet 5K52) and for mice on a high (15%) fat atherogenic diet.

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains blood lipids — cholesterol — HDL   Paigen2 HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline        • after 17wks on diet        • Δchange after diet          diet effect comparison   43 strains   age 7-9wks                 at baseline   blood lipids — cholesterol — non-HDL   Paigen2 non-HDL cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline        • after 17wks on diet        • Δchange after diet          diet effect comparison   43 strains   age 7-9wks                 at baseline   blood lipids — cholesterol — total   Paigen2 total cholesterol [mg/dL]     baseline and  high-fat diet 17wks       • baseline        • after 17wks on diet        • Δchange after diet          diet effect comparison   43 strains   age 7-9wks                 at baseline   blood lipids — triglycerides   Paigen2 triglycerides [mg/dL]     baseline and  high-fat diet 17wks       • baseline        • after 17wks on diet        • Δchange after diet          diet effect comparison   43 strains   age 7-9wks                 at baseline   cardiovascular — atherosclerosis   Paigen2 fatty streak aortic lesion size   [µm2]   high-fat diet   17wks 43 strains   age 25-27wks Display strain means in the above table for: select a strain 129S1/SvImJ A/J AKR/J BALB/cByJ BALB/cJ BTBR T+ tf/J BUB/BnJ C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ JF1/Ms KK/HlJ LP/J MA/MyJ MOLF/EiJ MSM/Ms NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ PERA/EiJ PL/J PWK/PhJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ   Compare two strains: select strain 1 129S1/SvImJ A/J AKR/J BALB/cByJ BALB/cJ BTBR T+ tf/J BUB/BnJ C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ JF1/Ms KK/HlJ LP/J MA/MyJ MOLF/EiJ MSM/Ms NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ PERA/EiJ PL/J PWK/PhJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ vs. select strain 2 129S1/SvImJ A/J AKR/J BALB/cByJ BALB/cJ BTBR T+ tf/J BUB/BnJ C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ JF1/Ms KK/HlJ LP/J MA/MyJ MOLF/EiJ MSM/Ms NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ PERA/EiJ PL/J PWK/PhJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ   Compare female vs. male for: select a strain 129S1/SvImJ A/J AKR/J BALB/cByJ BALB/cJ BTBR T+ tf/J BUB/BnJ C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ JF1/Ms KK/HlJ LP/J MA/MyJ MOLF/EiJ MSM/Ms NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ PERA/EiJ PL/J PWK/PhJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ   Display overall measurement averages (all strains combined) in the above table

Notes

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.     PubMed    MGI There have been 4 updates or corrections to the dataset since it was first released in May, 2003 Mice were housed in a barrier facility during the acclimation and testing periods. No pathogens were detected during this time. Pathogen-accelerated atherosclerosis was not observed in these studies in contrast to a similar study conducted in a non-barrier facility (Paigen1). Non-HDL values were computed by MPD (CHOL minus HDLC). Negative non-HDL values (possible due to differences in assay procedures) were adjusted to zero per the investigators. Fold change values were computed by MPD (when denominator = 0, fold change set to n/a). Please note. Some strain means have N < 3 animals (click for table). Some measurements were derived by MPD staff, based on supplied data (click for list). See also the investigators' web site. This is one of several projects supplied by Heart, Lung, Blood and Sleep Disorders Center.

Downloads             Help

The Paigen2 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Paigen2 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Paigen2 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Paigen2 protocol document HTML Paigen2 animal documentation HTML Supplemental data None