Diet-induced disease: Gallstones, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis.

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains blood chemistry — enzymes   Paigen1 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet   8wks 43 strains   age 15-19wks   blood chemistry — miscellaneous   Paigen1 bile salts (plasma)   [µmol/L]   high-fat diet   8wks 43 strains   age 15-19wks   blood lipids — cholesterol — HDL   Paigen1 HDL cholesterol (plasma)   high-fat diet   8wks       • amount        • % of total plasma cholesterol        43 strains   age 15-19wks   blood lipids — cholesterol — non-HDL   Paigen1 plasma cholesterol not in the HDL fraction   [mg/dL]   high-fat diet   8wks 43 strains   age 15-19wks   blood lipids — cholesterol — total   Paigen1 total cholesterol (plasma)   [mg/dL]   high-fat diet   8wks 43 strains   age 15-19wks   body weight   Paigen1 body weight [g]     baseline and  high-fat diet 8wks       • start        • after 8wks on diet        • Δchange after diet          diet effect comparison   43 strains   age 7-11wks                 at baseline   cardiovascular — atherosclerosis   Paigen1 fatty streak aortic lesion size   [µm2]   high-fat diet   8wks 43 strains   age 15-19wks   liver and gallbladder — function   Paigen1 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free        • esterified        • total        • free to esterified ratio        43 strains   age 15-19wks   liver and gallbladder — gallbladder pathology and gallstones   Paigen1 gallbladder volume   [µL]   high-fat diet   8wks 43 strains   age 15-19wks Paigen1 gallbladder pathology (0-4) [score]   high-fat diet   8wks       • mucin        • arc        • filaments        liquid crystals:             • small              • aggregated              • fused        • cholesterol monohydrate crystals        stones:             • sandy              • true              • all              • presence score              43 strains   age 15-19wks   liver and gallbladder — liver morphology   Paigen1 liver weight at sacrifice   [g]   high-fat diet   8wks 43 strains   age 15-19wks   liver and gallbladder — liver pathology   Paigen1 liver pathology (0-4) [score]   high-fat diet   8wks       • view images and scores        • microvacuoles        • macrovacuoles        • inflammation        43 strains   age 15-19wks   local experiment parameter   Paigen1 age at start of diet   [d] 43 strains   age 7-11wks Display strain means in the above table for: select a strain 129S1/SvImJ A/J AKR/J BALB/cJ BPH/2J BPL/1J BPN/3J BTBR T+ tf/J C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ KK/HlJ LP/J MOLF/EiJ NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ P/J PERA/EiJ PL/J RBF/DnJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ YBR/EiJ   Compare two strains: select strain 1 129S1/SvImJ A/J AKR/J BALB/cJ BPH/2J BPL/1J BPN/3J BTBR T+ tf/J C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ KK/HlJ LP/J MOLF/EiJ NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ P/J PERA/EiJ PL/J RBF/DnJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ YBR/EiJ vs. select strain 2 129S1/SvImJ A/J AKR/J BALB/cJ BPH/2J BPL/1J BPN/3J BTBR T+ tf/J C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ KK/HlJ LP/J MOLF/EiJ NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ P/J PERA/EiJ PL/J RBF/DnJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ YBR/EiJ   Compare female vs. male for: select a strain 129S1/SvImJ A/J AKR/J BALB/cJ BPH/2J BPL/1J BPN/3J BTBR T+ tf/J C3H/HeJ C57BL/10J C57BL/6J C57BLKS/J C57BR/cdJ C57L/J C58/J CAST/EiJ CBA/J CE/J CZECHII/EiJ DBA/1J DBA/2J FVB/NJ I/LnJ KK/HlJ LP/J MOLF/EiJ NOD/ShiLtJ NON/ShiLtJ NZB/BlNJ NZW/LacJ P/J PERA/EiJ PL/J RBF/DnJ RF/J RIIIS/J SEA/GnJ SJL/J SM/J SPRET/EiJ SWR/J WSB/EiJ YBR/EiJ   Display overall measurement averages (all strains combined) in the above table

Notes

There have been 8 updates or corrections to the dataset since it was first released in Feb, 2001 Mice were housed in a non-barrier facility during the acclimation and testing periods. Three pathogens were detected during this time: Pneumocystis, Pasturella, and Helicobacter. Pathogen-accelerated atherosclerosis was observed in these studies. These results are in contrast to a similar study conducted in a pathogen-free facility (Paigen2). Similar data are available for 6 mutant strains compared to C57BL/6J and C57BLKS/J; see Paigen3 (identical C57BL/6J and C57BLKS/J data are present in both data sets). This project includes a collection of browsable liver pathology images. Please note. Some strain means have N < 3 animals (click for table). Some measurements were derived by MPD staff, based on supplied data (click for list). This is one of several projects supplied by Heart, Lung, Blood and Sleep Disorders Center.

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The Paigen1 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Paigen1 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Paigen1 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Paigen1 protocol document HTML Paigen1 animal documentation HTML Supplemental data None