Xing1: Aging study: Electrocardiogram for 29 inbred strains of mice (2008)

Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1907-13. Epub 2009 Apr 24.   PubMed 19395551     FullText


         
Notes
Due to the difficulties in determining the exact beginning and ending of the T-wave in conscious mice, automatic software generated values for QT and ST intervals should be used with caution; see Figure 4 in the Xing1 protocol.

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Participants Shuqin Xing       The Jackson Laboratory Bar Harbor, ME
Ron Korstanje       The Jackson Laboratory Bar Harbor, ME
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
With: Schultz D, Godfrey D
ContactBeverly Paigen     bev.paigen@jax.org     Lab web site
AffiliationJackson Laboratory Nathan Shock Center
AcknowledgementsFunding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersXing1     MPD:249
Data changelog 1 update/correction.       Initial release date: 05/2009.
Formatted citation
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Summary of procedures that were conducted
• ECG Heart rate and wave intervals. Conscious. Aging study, 6mo, 12mo, 20mo.
Mice: inbred   29 strains   ♀♂   age 6, 12, 20 mo   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Xing1 24901 ECG (none) heart rate   [n/min]     6mo    12mo    20mo inbred 28 both None N=7
    Xing1 24916 ECG (none) interval RR   [ms]     6mo    12mo    20mo inbred 28 both None N=7
    Xing1 24921 ECG (none) interval PR   [ms]     6mo    12mo    20mo inbred 28 both None N=7
    Xing1 24926 ECG (none) interval QRS   [ms]     6mo    12mo    20mo inbred 28 both None N=7
    Xing1 24931 ECG (none) interval QT   [ms]     6mo    12mo    20mo inbred 28 both None N=7
    Xing1 24941 ECG (none) interval ST   [ms]     6mo    12mo    20mo inbred 28 both None N=7
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