Wiltshire3: Drug study: Neurobiochemical analytes in response to chronic fluoxetine treatment in males of 30 inbred mouse strains (2011)

Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24.   PubMed 22113448     FullText


         
Notes
The *_index values were derived from the related strain means for flouoxetine-treated and control. Nmice has been set to 3 for these, and SD to 0 since no error statistic is available.

Wiltshire3 downloads
• Download Wiltshire3 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Tim Wiltshire       University of North Carolina Chapel Hill, NC
Mathew T Pletcher       Pfizer Global Research and Development Groton, CT
With: Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Part of a series: • Behavior phenotype data   see Pletcher1
• Behavior phenotype data (fluoxetine study)   see Wiltshire2
• Neurobiochemical analyte data   (this project) Wiltshire3
AcknowledgementsFunding provided by NIH MH077251 and MH084528; State of Florida
In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersWiltshire3     MPD:381
Data changelog No updates/corrections.       Initial release date: 12/2011.
Formatted citation
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Neurobiochemical analytes thought to affect anxiety and mood disorders were measured to identify biomarkers of anti-depressant responses by comparing analyte levels to behavioral phenotypes (Wiltshire2) between two cohorts: 1) vehicle (control), and 2) fluoxetine (chronic treatment).

Summary of procedures that were conducted
• biomarker quantification Brain tissue survey of 30 biochemical analytes. Fluoxetine-treated vs. control. 21d.
Mice: inbred   30 strains   ♂   age 10-11wks   2 cohorts

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Wiltshire3 38101 biomarker quantification fluoxetine ACTH     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38104 biomarker quantification fluoxetine APOD     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38107 biomarker quantification fluoxetine BAG1     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38110 biomarker quantification fluoxetine BDNF     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38113 biomarker quantification fluoxetine CREB1 (CREB)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38116 biomarker quantification fluoxetine FOS (c-fos)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38119 biomarker quantification fluoxetine FUT9     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38122 biomarker quantification fluoxetine GAD1 (GAD67)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38125 biomarker quantification fluoxetine GAL     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38128 biomarker quantification fluoxetine GFAP     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38131 biomarker quantification fluoxetine GHRL     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38134 biomarker quantification fluoxetine GIRK3 (KCNJ9)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38137 biomarker quantification fluoxetine GLO1     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38140 biomarker quantification fluoxetine GNB1     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38143 biomarker quantification fluoxetine GRIN1 (NMDA1)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38146 biomarker quantification fluoxetine GSK3B     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38149 biomarker quantification fluoxetine GSR     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38152 biomarker quantification fluoxetine HDAC5     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38155 biomarker quantification fluoxetine NGF     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38158 biomarker quantification fluoxetine NPY     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38161 biomarker quantification fluoxetine P2RX7 (P2X7)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38164 biomarker quantification fluoxetine PAQR8     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38167 biomarker quantification fluoxetine PPP1R1B     control    fluoxetine inbred 30 m 10-11wks N=3
    Wiltshire3 38170 biomarker quantification fluoxetine PTH     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38173 biomarker quantification fluoxetine S100B     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38176 biomarker quantification fluoxetine SCG5 (SGNE)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38179 biomarker quantification fluoxetine SLC6A2 (NET)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38182 biomarker quantification fluoxetine SLC6A4 (SERT)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38185 biomarker quantification fluoxetine SST     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38188 biomarker quantification fluoxetine TNF (TNFa)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
    Wiltshire3 38191 biomarker quantification fluoxetine VEGFA (VEGF)     control    fluoxetine    change index inbred 30 m 10-11wks N=3
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