Wiltshire2: Drug study: Behavioral responses to chronic fluoxetine treatment in males of 30 inbred mouse strains (2011)

Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24.   PubMed 22113448     FullText


       
Wiltshire2 downloads
• Download Wiltshire2 project data set     one row per animal, one column per trait
• Download Wiltshire2 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Tim Wiltshire       University of North Carolina Chapel Hill, NC
Mathew T Pletcher       Pfizer Global Research and Development Groton, CT
With: Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Part of a series: • Behavior phenotype data   see Pletcher1
• Behavior phenotype data (fluoxetine study)   (this project) Wiltshire2
• Neurobiochemical analyte data   see Wiltshire3
AcknowledgementsFunding provided by NIH MH077251 and MH084528; State of Florida
Behavioral testing was conducted at The Scripps Research Institute.
In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersWiltshire2     MPD:380
Data changelog No updates/corrections.       Initial release date: 12/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Behaviors related to anxiety or mood disorders were assessed to identify biomarkers of anti-depressant responses by comparing behavioral phenotypes to neurobiochemical analyte levels (Wiltshire3) between two cohorts: 1) vehicle (control), and 2) fluoxetine (chronic treatment).

Summary of procedures that were conducted
• tail suspension test Immobility. Fluoxetine-treated vs. control. 5 min test.
• open field test Locomotor activity, exploratory and anxiety-related behavior. Fluoxetine-treated vs. control. 7 min test.
• drug and metabolite quantification Fluoxetine and norfluoxetine concentration (serum) after fluoxetine.
Mice: inbred   30 strains   ♂   age 9-11wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Wiltshire2 38001 tail suspension test fluoxetine TST duration of immobility   [%]     control    fluoxetine inbred 30 m 9-10wks N=10
    Wiltshire2 38003 open field test fluoxetine OFT center avoidance (thigmotaxis)   [%]     control    fluoxetine inbred 30 m 10-11wks N=11
    Wiltshire2 38005 open field test fluoxetine OFT distance traveled   [cm]     control    fluoxetine inbred 30 m 10-11wks N=11
    Wiltshire2 38007 drug and metabolite quantification fluoxetine drug and metabolite concentration   [ng/mL]     fluoxetine    norfluoxetine inbred 30 m 10-11wks N=11
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