Vulpe1: Basal liver mineral levels and iron homeostasis in 18 diverse mouse strains (2010)

McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ, Vulpe CD. In silico QTL mapping of basal liver iron levels in inbred mouse strains. Physiol Genomics. 2011 Feb 11;43(3):136-47. Epub 2010 Nov 9.   PubMed 21062905     FullText


       
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Participants Stela McLachlan       University of California, Berkeley Berkeley, CA
Chris D Vulpe       University of California, Berkeley Berkeley, CA
With: Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ
ContactChris D Vulpe     vulpe@berkeley.edu     Lab web site
AcknowledgementsFunding provided by NIH DK05637 and a Faculty Research Grant (CV)
Project type Phenotype strain survey data set
MPD identifiersVulpe1     MPD:368
Data changelog No updates/corrections.       Initial release date: 04/2011.
Formatted citation
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Summary of procedures that were conducted
• mineral quantification Liver mineral levels. Iron, copper, zinc. Iron homeostasis.
• transferrin quantification Diferric transferrin (plasma).
Mice: inbred   18 strains   ♀♂   age 8wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Vulpe1 36801 mineral quantification (none) copper (Cu) content in liver (dry weight)   [µg/g]  copper inbred 18 both 8wks N=6
    Vulpe1 36802 mineral quantification (none) iron (Fe) content in liver (dry weight)   [µg/g]  iron inbred 18 both 8wks N=6
    Vulpe1 36803 mineral quantification (none) zinc (Zn) content in liver (dry weight)   [µg/g]  zinc inbred 18 both 8wks N=6
    Vulpe1 36804 transferrin quantification (none) diferric transferrin (serum), percent of total transferrin   [%]  2Fe_transferrin inbred 18 both 8wks N=6
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