Vanderlinden1: Drinking in the dark alcohol consumption in 43 ILSXISS recombinant inbred strains of mice (2015)

Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff . Influence of sex on genetic regulation of 'drinking in the dark' alcohol consumption. Mamm Genome. 2015 Feb;26(1-2):43-56. doi: 10.1007/s00335-014-9553-8. Epub 2015 Jan 6.   PubMed 25559016     FullText


       
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Participants Lauren A Vanderlinden       University of Colorado Aurora, CO
Laura Saba       University of Colorado Denver School of Medicine Aurora, CO
Beth Bennett       University of Colorado Denver School of Medicine Aurora, CO
Paula A Hoffman       University of Colorado Denver School of Medicine Aurora, CO
Boris Tabakoff       University of Colorado Denver School of Medicine Aurora, CO
ContactLauren A Vanderlinden     lauren.vanderlinden@ucdenver.edu
AcknowledgementsFunding provided by NIH AA013162, AA16649; Banbury Fund
Project type Phenotype strain survey data set
MPD identifiersVanderlinden1     MPD:543
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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ILSXISS recombinant inbred mice were used to investigate genetic influences of alcohol consumption in the "drinking in the dark" model. Mice were given access to 20% ethanol during the early phase of their circadian dark cycle for four consecutive days. Alcohol-preferring strains of mice consume an amount of alcohol during this time that produces blood ethanol levels that are comparable to the levels that define binge drinking in humans.

Summary of procedures that were conducted
• body weight
• intake monitoring Ethanol consumed during 2h availability during dark phase. 4 days/trials with variations.
Mice: ILSXISS   43 strains   ♀♂   age 8-23wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Vanderlinden1 54301 body weight (none) body weight at start of experiment on day 1   [g]  bw ILSXISS 38 both 8-23wks N=8
    Vanderlinden1 54311 intake monitoring (none) ethanol consumed 'drinking in the dark'   [g]     day2    day3    day4 ILSXISS 38 both 8-23wks N=8
    Vanderlinden1 54321 intake monitoring (none) ethanol consumed 'drinking in the dark', log transformed   [log(g)]     day2    day3    day4 ILSXISS 38 both 8-23wks N=8
    Vanderlinden1 54331 intake monitoring (none) first principal component on log transformed 'drinking in the dark' measurements (days 2, 3, 4)  PC1 ILSXISS 38 both 8-23wks N=8
    All boxes