Thomsen1: Drug study: Psychomotor stimulant effects of cocaine in 15 mouse strains (2011)

Thomsen M, Caine SB. Psychomotor stimulant effects of cocaine in rats and 15 mouse strains. Exp Clin Psychopharmacol. 2011 Oct;19(5):321-41.   PubMed 21843010  


       
Thomsen1 downloads
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Participants Morgane Thomsen       Harvard Medical School Boston, MA
S Barak Caine       Harvard Medical School Boston, MA
ContactMorgane Thomsen     mthomsen@mclean.harvard.edu     Lab web site
Part of a series: • cocaine study   (this project) Thomsen1
• dopamine agonists study   see Thomsen2
AcknowledgementsFunding provided by NIH DA07252, DA12142, DA14528; Zaffaroni Foundation
Project type Phenotype strain survey data set
MPD identifiersThomsen1     MPD:407
Data changelog No updates/corrections.       Initial release date: 06/2012.
Formatted citation
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Mice were evaluated for response to a novel environment and assessed for dose-effects of cocaine-induced hyperactivity.

Summary of procedures that were conducted
• open field test Locomotor activity. Baseline (saline) vs. cocaine i.p. (several doses). 1.3h and 2.3 h duration.
Mice: inbred   15 strains   ♀♂   age 8-10wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Thomsen1 40701 open field test cocaine total activity, test 1   [n]     baseline    dose mg/kg i.p.:    3    10    18    32    56 inbred 15 both 8-10wks N=8
    Thomsen1 40707 open field test cocaine total activity, test 2   [n]     baseline    dose mg/kg i.p.:    3    10    32 inbred 15 both 8-10wks N=8
    All boxes