Solberg1: Depression-like behavior research in the reciprocal intercross of WKY and Fisher 344 rat strain (2004)

Solberg LC, Churchill GA

     
Solberg1 downloads
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Participants L C Solberg
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsPlease see the Excel file.
Project type QTL Archive data set
MPD identifiersSolberg1     MPD:150
Data changelog No updates/corrections.       Initial release date: 12/2010.
A reciprocal intercross of rat strain Wistar-Kyoto (WKY) and Fisher 344 (F344) was generated to identify quantitative trait locus (QTL) for depression-like behavior traits. The F2 generation was subjected to the forced swim test (FST) to measure the time of immobility, climbing and swimming. For detailed protocols, see Solberg et al. 2004.

This was a cross between rat strains thus no B37 map for data, the posted data is as provided by the authors. For more info on these rat strains please see RGD.

These tests were performed: 1) DB (15 minutes defensive burying test); 2) FST (5 minutes forced swim test); 3) OFT (10 minutes open-field test).


QTL data set parameters:
Cross direction notation(FxW) F1 x (FxW) F1; (WxF) F1 x (WxF) F1
Cross typeF2 reciprocal intercross
Population size 223 ♀     263 ♂
Notesrat population


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Solberg1 15001 defensive burying task (none) number of times a rat gets shocked in the defensive burying test   [n]  DBshocks QTL population both 11wks N=243
Solberg1 15002 defensive burying task (none) number of times a rat approaches the prod in the defensive burying test   [n]  DBapproaches QTL population both 11wks N=243
Solberg1 15003 defensive burying task (none) latency to begin burying in the defensive burying test   [min]  DBlatencytobury QTL population both 11wks N=243
Solberg1 15004 defensive burying task (none) duration of burying in the defensive burying test   [sec]  DBdurationofburying QTL population both 11wks N=243
Solberg1 15005 defensive burying task (none) number of rears in the defensive burying test   [n]  DBrears QTL population both 11wks N=243
Solberg1 15006 defensive burying task (none) time spent grooming in the defensive burying test   [sec]  DBgroomtime QTL population both 11wks N=243
Solberg1 15007 forced swim test (none) duration of climbing in FST   [sec]  FSTclimbing QTL population both 11wks N=243
Solberg1 15008 forced swim test (none) duration of immobility in FST   [sec]  FSTimmobility QTL population both 11wks N=243
Solberg1 15009 hormone quantification (none) thyroid-stimulating hormone   [ng/mL]  TSH QTL population both 15wks N=243
Solberg1 15010 open field test (none) number of inner lines crossed in the OFT   [n]  OFTinnerlinecrossing QTL population both 11wks N=243
Solberg1 15011 open field test (none) number of rears in the OFT   [n]  OFTrears QTL population both 11wks N=243
Solberg1 15012 open field test (none) time spent grooming in the OFT   [sec]  OFTgroomtime QTL population both 11wks N=243
Solberg1 15013 hormone quantification (none) basal plasma corticosterone level   [ng/mL]  CORT0 QTL population both not specified N=243
Solberg1 15014 hormone quantification (none) plasma corticosterone response to a 10 min restraint stress   [ng/mL]  CORT10 QTL population both not specified N=243
Solberg1 15015 organ weights (none) adrenal weight   [g]  adrenalwt QTL population both 17wks N=243
Solberg1 15016 body weight (none) body weight of rat in week 11   [g]  weight11 QTL population both 11wks N=243
Solberg1 15017 body weight (none) body weight of rat in week 17   [g]  weight17 QTL population both 17wks N=243
Solberg1 15018 metabolic panel (none) post-restraint stress glucose level   [mg/dL]  glucose30 QTL population both 15wks N=243
Solberg1 15019 metabolic panel (none) glucose post-challenge   [mg/dL]  glucpostglucchall QTL population both 17wks N=243
Solberg1 15020 metabolic panel (none) fasting glucose   [mg/dL]  fastinggluc QTL population both 17wks N=243
Solberg1 15021 hormone quantification (none) insulin post-challenge   [µU/mL]  insulinpostglucchall QTL population both 17wks N=243
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Project / data set:   Solberg1     a.k.a. Solberg_2004
Excel file:   Data_Description_FxW_Solberg2004.xlsx
CSV file:   Solberg2004_F344xWKY_Data.csv
Readme / text file:   readme_Solberg2004.txt


References   (chronological)

1.   Ahmadiyeh N, Churchill GA, Shimomura K, Solberg LC, Takahashi JS, Redei EE. X-linked and lineage-dependent inheritance of coping responses to stress. Mamm Genome. 2003 Nov;14(11):748-57.   PubMed 14722724  

2.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Mamm Genome. 2004 Aug;15(8):648-62.   PubMed 15457344  

3.   Baum AE, Solberg LC, Kopp P, Ahmadiyeh N, Churchill G, Takahashi JS, Jameson JL, Redei EE. Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. Endocrinology. 2005 Feb;146(2):870-8. Epub 2004 Oct 28.   PubMed 15514085  

4.   Ahmadiyeh N, Churchill GA, Solberg LC, Baum AE, Shimomura K, Takahashi JS, Redei EE. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Behav Genet. 2005 Mar;35(2):189-98.   PubMed 15685431  

5.   Baum AE, Solberg LC, Churchill GA, Ahmadiyeh N, Takahashi JS, Redei EE. Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality. Behav Brain Res. 2006 May 15;169(2):220-30. Epub 2006 Feb 20.   PubMed 16490266  

6.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Takahashi JS, Churchill GA, Redei EE. Genetic analysis of the stress-responsive adrenocortical axis. Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8.   PubMed 16895972  

7.   Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE. Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome. 2009 Aug;20(8):486-97. Epub 2009 Aug 22.   PubMed 19697080     FullText