Shockley1: Diet effects on blood chemistry and lipids in 10 inbred strains of mice (2008)

Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA. Effects of atherogenic diet on hepatic gene expression across mouse strains. Physiol Genomics. 2009 Nov 6;39(3):172-82. Epub 2009 Aug 11.   PubMed 19671657     FullText


       
Shockley1 downloads
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• Download Shockley1 strain means, SD, N, etc.     one row per strain/sex/measure
• Shockley1 supplementary data
Participants Keith Shockley       The Jackson Laboratory Bar Harbor, ME
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Witmer D, Burgess-Herbert SL
ContactKeith Shockley     shockleykr@niehs.nih.gov     Lab web site
AffiliationCenter for Genome Dynamics (CGD)
Part of a series: • Phenotype data   (this project) Shockley1
• Gene expression, control group   see Shockley2
• Gene expression, high-fat diet group   see Shockley3
AcknowledgementsFunding provided by NIH GM076468, HL77796, HL74086; HG003968

Additional funding was provided by Novartis Institutes for Biomedical Research (Boston, MA), Howard Hughes Medical Institute, Betterment Fund Scholarship Endowment, Clarence Cook Little Scholarship Fund, LG Balfour Foundation, and Horace W. Goldsmith Foundation.
Project type Phenotype strain survey data set
MPD identifiersShockley1     MPD:334
Data changelog 1 update/correction.       Initial release date: 02/2010.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of metabolic response to atherogenic (high-fat) diet. Two cohorts: control diet group and high-fat diet group. Animals were evaluated using Beckman CX5 Synchron Delta Chemistry Autoanalyzer.

Summary of procedures that were conducted
• body weight High-fat diet for 4wks vs. control.
• lipid profile Cholesterol, HDL, triglycerides, fatty acids. High-fat diet (4wks) vs. control. 5h fast, serum.
• metabolic panel Clinical blood chemistry measures (serum). High-fat diet (4wks) vs. control.
Mice: inbred   10 strains   ♀♂   age 10-13wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Shockley1 33401 body weight high fat diet body weight   [g]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33402 metabolic panel high fat diet blood urea nitrogen (BUN)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=4
    Shockley1 33403 metabolic panel high fat diet calcium (Ca)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33404 metabolic panel high fat diet glutamate dehydrogenase (GLDH)   [IU/L]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33405 metabolic panel high fat diet glucose (GLU, 4h fast)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33406 lipid profile high fat diet total cholesterol (CHOL)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33407 lipid profile high fat diet HDL cholesterol (HDL)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33408 lipid profile high fat diet nonesterified fatty acid (NEFA)   [mEq/L]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33409 lipid profile high fat diet triglycerides (TG, 5h fast)   [mg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
    Shockley1 33410 metabolic panel high fat diet thyroxine (T4)   [µg/dL]     control diet    high-fat diet    difference inbred 10 both 10-13wks N=5
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