MPD: Data set: Shockley1

Shockley1: Diet effects on blood chemistry and lipids in 10 inbred strains of mice (2008)

Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA. Effects of atherogenic diet on hepatic gene expression across mouse strains. Physiol Genomics. 2009 Nov 6;39(3):172-82. Epub 2009 Aug 11. PubMed 19671657 FullText

Shockley1 downloads
• Download Shockley1 project data set animal data, as uploaded
• Download Shockley1 animal data matrix with factor-related expansion applied as necessary
• Download Shockley1 strain means, SD, N, etc. one row per strain/sex/measure
• Shockley1 supplementary data

Ontology terms mapped to Shockley1 measures:

Investigators	Keith Shockley The Jackson Laboratory, Bar Harbor, ME Beverly Paigen The Jackson Laboratory, Bar Harbor, ME Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Witmer D, Burgess-Herbert SL
Contact	Keith Shockley shockleykr@niehs.nih.gov Lab web site
Affiliated Center	Center for Genome Dynamics (CGD)
Part of a series:	• Phenotype data (this project) Shockley1
Acknowledgements	Funding provided by NIH GM076468, HL77796, HL74086; HG003968 Additional funding was provided by Novartis Institutes for Biomedical Research (Boston, MA), Howard Hughes Medical Institute, Betterment Fund Scholarship Endowment, Clarence Cook Little Scholarship Fund, LG Balfour Foundation, and Horace W. Goldsmith Foundation.
Project type	Phenotype strain survey data set
MPD identifiers	Shockley1 MPD:334
Data changelog	1 update/correction. Initial release date: 02/2010.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An investigation of metabolic response to atherogenic (high-fat) diet. Two cohorts: control diet group and high-fat diet group. Animals were evaluated using Beckman CX5 Synchron Delta Chemistry Autoanalyzer.

Procedures conducted:

• body weight		High-fat diet for 4wks vs. control.
• lipid profile		Cholesterol, HDL, triglycerides, fatty acids. High-fat diet (4wks) vs. control. 5h fast, serum.
• metabolic panel		Clinical blood chemistry measures (serum). High-fat diet (4wks) vs. control.

Mice: inbred 10 strains ♀♂ age 10-13wks 2 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Shockley1:1	Shockley1	body weight	high-fat diet	body weight [g] BW 33401 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:2	Shockley1	metabolic panel	high-fat diet	blood urea nitrogen (BUN) [mg/dL] BUN 33402 control diet high-fat diet difference	inbred	10	both	10-13wks	N=4

Shockley1:3	Shockley1	metabolic panel	high-fat diet	calcium (serum Ca) [mg/dL] CA 33403 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:4	Shockley1	metabolic panel	high-fat diet	glutamate dehydrogenase (GLDH) [IU/L] GLDH 33404 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:5	Shockley1	metabolic panel	high-fat diet	glucose (serum GLU, 5h fast) [mg/dL] GLU 33405 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:6	Shockley1	lipid profile	high-fat diet	total cholesterol (CHOL) [mg/dL] CHOL 33406 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:7	Shockley1	lipid profile	high-fat diet	HDL cholesterol (HDL) [mg/dL] HDL 33407 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:8	Shockley1	lipid profile	high-fat diet	nonesterified fatty acid (NEFA) [mEq/L] NEFA 33408 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:9	Shockley1	lipid profile	high-fat diet	triglycerides (TG, 5h fast) [mg/dL] TG 33409 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5

Shockley1:10	Shockley1	metabolic panel	high-fat diet	thyroxine (T4) [µg/dL] T4 33410 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5