MPD: Data set: Shin1

Shin1: Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice (2016)

Keum S, Park J, Kim A, Park J, Kim KK, Jeong J, Shin HS. Variability in empathic fear response among 11 inbred strains of mice. Genes Brain Behav. 2016 Feb;15(2):231-42. doi: 10.1111/gbb.12278. Epub 2016 Jan 12. PubMed 26690560

Shin1 downloads
• Download Shin1 project data set animal data, as uploaded
• Download Shin1 animal data matrix with factor-related expansion applied as necessary
• Download Shin1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Shin1 measures:

MP:0001360 abnormal social investigation
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001469 abnormal contextual conditioning behavior
MP:0002062 abnormal associative learning
MP:0003106 abnormal fear-related response
MP:0003107 abnormal response to novelty
MP:0013189 abnormal exploration in a new environment
VT:0001360 social investigation trait
VT:0001392 locomotor behavior trait
VT:0010459 behavioral response to novel environment trait
VT:0010471 exploratory behavior trait
VT:0010527 associative learning trait
VT:0010529 contextual fear conditioning behavior trait
VT:0010709 behavioral response to novel object trait
VT:0010715 fear-related behavior trait
VT:0010716 anxiety-related behavior trait

Investigators	Hee-Sup Shin Institute for Basic Science, Daejeon REPUBLIC OF KOREA Sehoon Keum Institute for Basic Science, Daejeon REPUBLIC OF KOREA
Participants	Park J, Kim A, Park J, Kim KK, Jeong J
Contact	Hee-Sup Shin shin@ibs.re.kr
Acknowledgements	Funding provided by the Institute for Basic Science (IBS-R001-G1), Republic of Korea
Project type	Phenotype strain survey data set
MPD identifiers	Shin1 MPD:545
Data changelog	No updates/corrections. Initial release date: 04/2016.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Empathy is an important emotional process that involves the ability to recognize and share emotions with others. In the observational fear learning task, a mouse is conditioned for context-dependent fear when it observes a con-specific demonstrator receiving aversive stimuli. Naïve mice that had no prior experience on any behaviors were used only once for each behavioral assay: observational fear learning, Pavlovian fear conditioning, open field test, elevated plus maze, and three-chambered social approach.

Procedures conducted:

• observational fear learning test		Percent time freezing to conditioning and contextual exposure.
• fear conditioning test		Pavlovian fear conditioning.
• open field test		Locomotor activity and exploratory behavior. 5 min test.
• elevated plus maze		Exploratory and anxiety-related behaviors. 5 min test.
• three chamber assay		Sociability testing. Tolerance of a novel mouse, a novel object, and second novel mouse vs. first. 10 min test.

Mice: inbred 11 strains ♂ age 12-14wks 5 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Shin1:1	Shin1	observational fear learning test	(none)	percent time freezing during 4 min of conditioning (empathic fear) [%] OFL_conditioning 54501	inbred	11	m	12-14wks	N=13

Shin1:2	Shin1	observational fear learning test	(none)	percent time freezing during 4 min of contextual exposure (empathic fear) [%] OFL_memory 54502	inbred	11	m	12-14wks	N=13

Shin1:3	Shin1	fear conditioning test	(none)	percent time freezing during 5 min of contextual exposure [%] FC_memory 54503	inbred	11	m	12-14wks	N=10

Shin1:4	Shin1	open field test	(none)	distance traveled per second during first 5 min [cm/s] OFT_activity 54504	inbred	11	m	12-14wks	N=10

Shin1:5	Shin1	open field test	(none)	percent time in center for first 5 min [%] OFT_center 54505	inbred	11	m	12-14wks	N=10

Shin1:6	Shin1	elevated plus maze	(none)	percent time spent in open arms for 5 min [%] EPM_open 54506	inbred	11	m	12-14wks	N=13

Shin1:7	Shin1	three chamber assay	(none)	time spent with novel mouse (stranger1) during 10 min test [s] sociability_mouse 54507	inbred	11	m	12-14wks	N=12

Shin1:8	Shin1	three chamber assay	(none)	time spent with novel object during 10 min test [s] sociability_object 54508	inbred	11	m	12-14wks	N=12

Shin1:9	Shin1	three chamber assay	(none)	time spent with stranger1 mouse during 10 min test [s] novelty_stranger1 54509	inbred	11	m	12-14wks	N=12

Shin1:10	Shin1	three chamber assay	(none)	time spent with novel stranger2 mouse during 10 min test [s] novelty_stranger2 54510	inbred	11	m	12-14wks	N=12

Shin1: Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice (2016)

Filter Table Results