Shin1: Observational fear learning, anxiety, locomotor activity, and social behavior in males of 11 inbred strains of mice (2016)

Keum S, Park J, Kim A, Park J, Kim KK, Jeong J, Shin HS. Variability in empathic fear response among 11 inbred strains of mice. Genes Brain Behav. 2016 Feb;15(2):231-42. doi: 10.1111/gbb.12278. Epub 2016 Jan 12.   PubMed 26690560  


       
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Participants Hee-Sup Shin       Institute for Basic Science Daejeon REPUBLIC OF KOREA
Sehoon Keum       Institute for Basic Science Daejeon REPUBLIC OF KOREA
With: Park J, Kim A, Park J, Kim KK, Jeong J
ContactHee-Sup Shin     shin@ibs.re.kr
AcknowledgementsFunding provided by the Institute for Basic Science (IBS-R001-G1), Republic of Korea
Project type Phenotype strain survey data set
MPD identifiersShin1     MPD:545
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Empathy is an important emotional process that involves the ability to recognize and share emotions with others. In the observational fear learning task, a mouse is conditioned for context-dependent fear when it observes a con-specific demonstrator receiving aversive stimuli. Naïve mice that had no prior experience on any behaviors were used only once for each behavioral assay: observational fear learning, Pavlovian fear conditioning, open field test, elevated plus maze, and three-chambered social approach.

Summary of procedures that were conducted
• observational fear learning test Percent time freezing to conditioning and contextual exposure.
• fear conditioning test Pavlovian fear conditioning.
• open field test Locomotor activity and exploratory behavior. 5 min test.
• elevated plus maze Exploratory and anxiety-related behaviors. 5 min test.
• three chamber assay Sociability testing. Tolerance of a novel mouse, a novel object, and second novel mouse vs. first. 10 min test.
Mice: inbred   11 strains   ♂   age 12-14wks   5 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Shin1 54501 observational fear learning test (none) percent time freezing during 4 min of conditioning (empathic fear)   [%]  OFL_conditioning inbred 11 m 12-14wks N=13
    Shin1 54502 observational fear learning test (none) percent time freezing during 4 min of contextual exposure (empathic fear)   [%]  OFL_memory inbred 11 m 12-14wks N=13
    Shin1 54503 fear conditioning test (none) percent time freezing during 5 min of contextual expoure   [%]  FC_memory inbred 11 m 12-14wks N=10
    Shin1 54504 open field test (none) distance traveled per second during first 5 min   [cm/s]  OFT_activity inbred 11 m 12-14wks N=10
    Shin1 54505 open field test (none) percent time in center for first 5 min   [%]  OFT_center inbred 11 m 12-14wks N=10
    Shin1 54506 elevated plus maze (none) percent time spent in open arms for 5 min   [%]  EPM_open inbred 11 m 12-14wks N=13
    Shin1 54507 three chamber assay (none) time spent with novel mouse (stranger1) during 10 min test   [s]  sociability_mouse inbred 11 m 12-14wks N=12
    Shin1 54508 three chamber assay (none) time spent with novel object during 10 min test   [s]  sociability_object inbred 11 m 12-14wks N=12
    Shin1 54509 three chamber assay (none) time spent with stranger1 mouse during 10 min test   [s]  novelty_stranger1 inbred 11 m 12-14wks N=12
    Shin1 54510 three chamber assay (none) time spent with novel stranger2 mouse during 10 min test   [s]  novelty_stranger2 inbred 11 m 12-14wks N=12
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