Schughart2: Susceptibility to influenza A (H1N1) viral infection in females of 53 BXD recombinant inbred strains of mice (2012)

Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heßman M, Alberts R, Williams RW, Schughart K. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. BMC Genomics. 2012 Aug 20;13:41doi: 10.1186/1471-2164-13-411.   PubMed 22905720     FullText


       
Schughart2 downloads
• Download Schughart2 project data set     one row per animal, one column per trait
• Download Schughart2 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Klaus Schughart       Helmholtz Center for Infection Research Braunschweig GERMANY
Robert W Williams       University of Tennessee Memphis, TN
With: Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heßman M, Alberts R
ContactKlaus Schughart     Klaus.Schughart@helmholtz-hzi.de     Lab web site
Part of a series: • 9 inbred strains   see Schughart1
• 53 BXD strains   (this project) Schughart2
AcknowledgementsFunding provided by German Ministry of Education FluResearchNet (01KI07137); Helmholtz-Association (Program Infection and Immunity; virtual institute 'GeNeSys')
Project type Phenotype strain survey data set
MPD identifiersSchughart2     MPD:496
Data changelog No updates/corrections.       Initial release date: 04/2014.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice infected with influenza A H1N1 (PR8) virus were analyzed for subsequent daily weight loss and survival over a period of 13 d.

Summary of procedures that were conducted
• body weight Influenza A (H1N1) virus vs. baseline. Several timepoints..
• health assessment Survival rate, susceptibility, influenza A (H1N1) virus.
Mice: BXD   56 strains including progenitors   ♀   age 9-18wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schughart2 49601 body weight influenza A (H1N1) virus  baseline body weight, pre-infection   [g]  bw BXD w/par 56 f 9-18wks N=6
    Schughart2 49602 body weight influenza A (H1N1) virus percent change in body weight, post-infection   [%]     day 1    day 3    day 7 BXD w/par 56 f 9-18wks N=6
    Schughart2 49606 health assessment influenza A (H1N1) virus survival, post-infection (in days)   [d]  survival_days BXD w/par 56 f 9-18wks N=6
    Schughart2 49607 health assessment influenza A (H1N1) virus susceptibility to viral infection
(0=susceptible; 1=resistant)   [designation]
 susceptibility
BXD w/par 56 f 9-18wks N=6
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