Schughart1: Susceptibility to influenza A (H1N1) viral infection in females of 9 strains of mice (2009)

Srivastava B, Błazejewska P, Hessmann M, Bruder D, Geffers R, Mauel S, Gruber AD, Schughart K. Host genetic background strongly influences the response to influenza a virus infections. PLoS One. 2009;4(3):e4857. Epub 2009 Mar 18.   PubMed 19293935     FullText


       
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Participants Klaus Schughart       Helmholtz Center for Infection Research Braunschweig GERMANY
With: Srivastava B, Błazejewska P, Hessmann M, Bruder D, Geffers R, Mauel S, Gruber AD
ContactKlaus Schughart     Klaus.Schughart@helmholtz-hzi.de     Lab web site
Part of a series: • 9 inbred strains   (this project) Schughart1
• 53 BXD strains   see Schughart2
AcknowledgementsFunding provided by Helmholtz-Association (Program Infection and Immunity); German Ministry of Education and Research (FluResearchNet 01KI07137); Georg-Christoph-Lichtenberg Foundation
Project type Phenotype strain survey data set
MPD identifiersSchughart1     MPD:393
Data changelog No updates/corrections.       Initial release date: 03/2012.
Formatted citation
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Mice infected with influenza A H1N1 (PR8) virus were analyzed for subsequent daily weight and survival over a period of 2 wks.

Summary of procedures that were conducted
• body weight Influenza A (H1N1) virus vs. baseline. Several timepoints.
• health assessment Strain susceptibility score, influenza A (H1N1) virus.
Mice: inbred   9 strains   ♀♂   age 10-12wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schughart1 39301 body weight influenza A (H1N1) virus percent change in body weight   [%]     day 1    day 3    day 7    day 12 inbred 9 both 10-12wks N=10
    Schughart1 39305 health assessment influenza A (H1N1) virus susceptibility to viral infection
(0=susceptible; 1=resistant)   [designation]
 susceptibility
inbred 9 both 10-12wks N=11
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