Schonfeld1: Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice (2005)

Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9.   PubMed 15591160  


       
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Participants Gustav Schonfeld       Washington University School of Medicine St. Louis, MO
With: Lin X, Yue P, and Chen Z
ContactGustav Schonfeld     gschonfe@wustl.edu
AcknowledgementsFunding provided by NIH HL42446, HL59515, HL52139, RR00036, DK20579, DK56341, DK52574

Support from the following sources: Alan and Edith Wolf Charitable Fund
Project type Phenotype strain survey data set
MPD identifiersSchonfeld1     MPD:323
Data changelog 1 update/correction.       Initial release date: 12/2009.
Formatted citation
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An investigation of liver triglyceride (TG) levels and development of fatty liver following fasting. Animals were surveyed for blood glucose/insulin metabolism and tolerance, blood and liver lipid metabolism, liver and body weights, and overall fat composition. An analysis (3 strains) of the effect of different fasting times (0h, 6h, 14h) for BHB, FFA, and hTG is available here.

Summary of procedures that were conducted
• body weight
• glucose tolerance 0 to 120 min after 10% glucose i.p. 5h fast.
• insulin tolerance 0 to 120 min after insulin i.p. 5h fast.
• lipid profile Cholesterol, triglycerides, free fatty acids, phospholipids. 5h fast, plasma. Hepatic triglycerides.
• metabolic panel Glucose, beta-hydroxybutyrate (plasma). No fast.
• organ weights Liver weight.
• DXA Fat mass.
• hormone quantification Insulin level, 30 min post-injection in glucose tolerance test. 10% glucose. 5h fast.
Mice: inbred   11 strains   ♀♂   age 8-10wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schonfeld1 32301 metabolic panel (none) glucose (plasma GLU, no fast)   [mg/dL]  GLU inbred 10 both 9-13wks N=6
    Schonfeld1 32303 glucose tolerance (none) glucose levels during glucose tolerance test
(10% glucose i.p., 5h fast)   [mg/dL]
    0min    30min    60min    120min
inbred 10 both 9-13wks N=5
    Schonfeld1 32308 glucose tolerance (none) glucose levels, area under curve, glucose tolerance test
(10% glucose i.p., 5h fast)   [AUC]
    0 to 60min    0 to 120min
inbred 10 both 9-13wks N=5
    Schonfeld1 32311 hormone quantification (none) insulin level (plasma), 30 min post injection in glucose tolerance test
(10% glucose i.p., 5h fast)   [ng/mL]
 Insulin
inbred 10 both 9-13wks N=5
    Schonfeld1 32313 insulin tolerance (none) glucose levels as percent of baseline, insulin tolerance test
(human insulin 0.75 U/kg bw i.p., 5h fast)   [%]
    0min    30min    60min    120min
inbred 10 both 9-13wks N=5
    Schonfeld1 32318 insulin tolerance (none) glucose levels, area under curve, insulin tolerance test
(human insulin 0.75 U/kg bw i.p., 5h fast)   [AUC]
    0 to 60min    0 to 120min
inbred 10 both 9-13wks N=5
    Schonfeld1 32331 lipid profile (none) total cholesterol (plasma CHOL)   [mg/dL]  TC inbred 10 both 9-13wks N=6
    Schonfeld1 32332 lipid profile (none) free cholesterol (plasma)   [mg/dL]  FC inbred 10 both 9-13wks N=6
    Schonfeld1 32333 lipid profile (none) cholesterol ester (plasma)   [mg/dL]  CE inbred 10 both 9-13wks N=6
    Schonfeld1 32334 lipid profile (none) free fatty acids (plasma FFA)   [mol/m3]  FFA inbred 9 both 9-13wks N=5
    Schonfeld1 32335 lipid profile (none) phospholipids (plasma)   [mg/dL]  PL inbred 10 both 9-13wks N=6
    Schonfeld1 32340 metabolic panel (none) beta-hydroxybutyrate (plasma BHB)   [mM]  BHB inbred 10 both 9-13wks N=6
    Schonfeld1 32343 lipid profile (none) triglycerides (plasma TG, 5h fast)   [mg/dL]  TG inbred 10 both 9-13wks N=6
    Schonfeld1 32348 lipid profile (none) hepatic triglycerides (5h fast)   [mg/g]  hTG inbred 10 both 9-13wks N=6
    Schonfeld1 32351 DXA (none) percent fat, head excluded   [%]  pct_fat inbred 10 both 9-13wks N=6
    Schonfeld1 32354 body weight (none) body weight   [g]  BW inbred 10 both 9-13wks N=6
    Schonfeld1 32361 organ weights (none) liver weight   [g]  LW inbred 10 both 9-13wks N=6
    Schonfeld1 32362 organ weights (none) liver weight as a percent of body weight   [%]  LW_BW inbred 10 both 9-13wks N=6
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