Schauwecker1: Drug study: Pilocarpine-induced status epilepticus in 11 inbred strains of mice (2012)

Schauwecker PE. Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus. Neurobiol Dis. 2012 Jan;45(1):297-304. doi: 10.1016/j.nbd.2011.08.013. Epub 2011 Aug 22.   PubMed 21878392     FullText


       
Schauwecker1 downloads
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Participants P Elyse Schauwecker       University of Southern California Los Angeles, CA
With: Kornacki M, Lorenzana A, Chancer Z, McCord M
ContactP Elyse Schauwecker     schauwec@usc.edu     Lab web site
AcknowledgementsFunding provided by NIH NS038696
Project type Phenotype strain survey data set
MPD identifiersSchauwecker1     MPD:477
Data changelog No updates/corrections.       Initial release date: 06/2013.
Formatted citation
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Summary of procedures that were conducted
• health assessment Study of pilocarpine effect on epilepticus seizures.
Mice: inbred   11 strains   ♂   age 8-10wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schauwecker1 47701 health assessment pilocarpine pilocarpine dose required to induce status epilepticus (mg/kg body weight)   [mg/kg]  ED100 inbred 8 m 8-10wks N=4
    Schauwecker1 47702 health assessment pilocarpine latency to onset of stage 4 status epilepticus seizures   [min]  latency inbred 8 m 8-10wks N=4
    Schauwecker1 47703 health assessment pilocarpine duration of stage 4 status epilepticus seizures   [min]  duration inbred 8 m 8-10wks N=4
    Schauwecker1 47704 health assessment pilocarpine status epilepticus seizure mortality (0=died; 1=survived)   [designation]  survival inbred 11 m 8-10wks N=18
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