Male mice from 45 strains of the Collaborative Cross were orally administered a single dose of tetrachloroethylene (percholorethylene, PERC) or vehicle and euthanized at various time points to generate population-level concentration-time profiles for PERC and its primary oxidative metabolite trichloroacetate (TCA) across multiple tissues. Toxicodynamic phenotyping included study of the expression of CYPs and dysregulation of hepatic lipid metabolism.

Participants	Joseph A Cichocki       Texas A&M University College Station, TX Ivan Rusyn       Texas A&M University College Station, TX With: Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chui WA, Threadgill DW
Contact	Ivan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
Project type	Phenotype archive study
MPD identifiers	Rusyn7     MPD:590
Data changelog	No updates/corrections.       Initial release date: 05/2017.
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