Rusyn2: Effects of trichloroethylene in males of 17 inbred mouse strains (2010)

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6.   PubMed 21135412     FullText


       
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Participants Ivan Rusyn       Texas A&M University College Station, TX
David W Threadgill       Texas A&M University College Station, TX
With: Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Tryndyak V, Pogribny IP, Bleyle L, Koop DR
ContactIvan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
Part of a series: • Phenotype data   (this project) Rusyn2
• Gene expression, control group   see Rusyn3
• Gene expression, TCE group   see Rusyn4
AcknowledgementsFunding provided by NIH ES005948
Project type Phenotype strain survey data set
MPD identifiersRusyn2     MPD:361
Data changelog No updates/corrections.       Initial release date: 04/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Summary of procedures that were conducted
• metabolic panel Blood urea nitrogen, alanine transaminase, aspartate transaminase (serum). Baseline and trichloroethylene-exposed (several timepoints). No fast.
• drug and metabolite quantification Trichloroethylene metabolites in serum, 2h, 4h, 24h after trichoroethylene exposure.
Mice: inbred   17 strains   ♂   age 7wks   3 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Rusyn2 36111 metabolic panel (none) alanine transaminase (serum ALT), naive   [IU/L]  ALT inbred 16 m 7wks N=3
    Rusyn2 36112 metabolic panel trichloroethylene alanine transaminase (serum ALT)   [IU/L]     control group:    2h    8h    24h inbred 16 m 7wks N=3
    Rusyn2 36117 metabolic panel trichloroethylene ALT   [IU/L]     treated group:    2h    8h    24h inbred 16 m 7wks N=3
    Rusyn2 36121 metabolic panel (none) aspartate transaminase (serum AST), naive   [IU/L]  AST inbred 15 m 7wks N=3
    Rusyn2 36122 metabolic panel trichloroethylene aspartate transaminase (serum AST)   [IU/L]     control group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36127 metabolic panel trichloroethylene AST   [IU/L]     treated group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36131 metabolic panel (none) blood urea nitrogen (serum BUN), naive   [mg/dL]  BUN inbred 15 m 7wks N=3
    Rusyn2 36132 metabolic panel trichloroethylene blood urea nitrogen (serum BUN)   [mg/dL]     control group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36137 metabolic panel trichloroethylene blood urea nitrogen   [mg/dL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36167 drug and metabolite quantification trichloroethylene dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36175 drug and metabolite quantification trichloroethylene trichloroacetic acid (serum TCA)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3
    Rusyn2 36185 drug and metabolite quantification trichloroethylene DCV cysteine (serum DCVC x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2
    Rusyn2 36195 drug and metabolite quantification trichloroethylene DCV glutathione (serum DCVG x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2
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