MPD: Data set: Rusyn2

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6. PubMed 21135412 FullText

Rusyn2 downloads
• Download Rusyn2 project data set animal data, as uploaded
• Download Rusyn2 animal data matrix with factor-related expansion applied as necessary
• Download Rusyn2 strain means, SD, N, etc. one row per strain/sex/measure
• Rusyn2 supplementary data

Ontology terms mapped to Rusyn2 measures:

MA:0002502 serum
MP:0000203 abnormal circulating aspartate transaminase level
MP:0001573 abnormal circulating alanine transaminase level
MP:0005265 abnormal blood urea nitrogen level
MP:0005332 abnormal amino acid level
MP:0008872 abnormal physiological response to xenobiotic
MP:0011601 abnormal glutathione peroxidase activity
MP:0012696 abnormal trichloroethene metabolism
VT:0000203 blood aspartate transaminase amount
VT:0001573 blood alanine transaminase amount
VT:0002121 metabolism trait
VT:0005265 blood urea nitrogen amount
VT:0010487 response to xenobiotic stimulus trait

Investigators	Ivan Rusyn Texas A&M University, College Station, TX David W Threadgill Texas A&M University, College Station, TX
Participants	Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Tryndyak V, Pogribny IP, Bleyle L, Koop DR
Contact	Ivan Rusyn IRusyn@cvm.tamu.edu Lab web site
Part of a series:	• Phenotype data (this project) Rusyn2
Acknowledgements	Funding provided by NIH ES005948
Project type	Phenotype strain survey data set
MPD identifiers	Rusyn2 MPD:361
Data changelog	No updates/corrections. Initial release date: 04/2011.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Procedures conducted:

• metabolic panel		Blood urea nitrogen, alanine transaminase, aspartate transaminase (serum). Baseline and trichloroethylene-exposed (several timepoints). No fast.
• drug and metabolite quantification		Trichloroethylene metabolites in serum, 2h, 4h, 24h after trichoroethylene exposure.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Rusyn2:1	Rusyn2	body weight	(none)	body weight, naive (local parameter) [g] BW 36101	inbred	14	m	7wks	N=3

Rusyn2:2	Rusyn2	body weight	(none)	body weight, t=2h (local parameter) [g] BW_2_ctrl 36102	inbred	16	m	7wks	N=3

Rusyn2:3	Rusyn2	body weight	(none)	body weight, t=8h (local parameter) [g] BW_8_ctrl 36103	inbred	17	m	7wks	N=3

Rusyn2:4	Rusyn2	body weight	(none)	body weight, t=24h (local parameter) [g] BW_24_ctrl 36104	inbred	16	m	7wks	N=3

Rusyn2:7	Rusyn2	body weight	(none)	body weight, t=2h (local parameter) [g] BW_2_tce 36107	inbred	16	m	7wks	N=3

Rusyn2:8	Rusyn2	body weight	(none)	body weight, t=8h (local parameter) [g] BW_8_tce 36108	inbred	17	m	7wks	N=3

Rusyn2:9	Rusyn2	body weight	(none)	body weight, t=24h (local parameter) [g] BW_24_tce 36109	inbred	16	m	7wks	N=3

Rusyn2:11	Rusyn2	metabolic panel	(none)	alanine transaminase (serum ALT), naive [IU/L] ALT 36111	inbred	16	m	7wks	N=3

Rusyn2:12	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] ALT_ctrl 36112 time: 2h 8h 24h	inbred	17	m	7wks	N=3

Rusyn2:17	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] ALT_tce 36117 time: 2h 8h 24h	inbred	17	m	7wks	N=3

Rusyn2:21	Rusyn2	metabolic panel	(none)	aspartate transaminase (serum AST), naive [IU/L] AST 36121	inbred	15	m	7wks	N=3

Rusyn2:22	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] AST_ctrl 36122 time: 2h 8h 24h	inbred	16	m	7wks	N=3

Rusyn2:27	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] AST_tce 36127 time: 2h 8h 24h	inbred	16	m	7wks	N=3

Rusyn2:31	Rusyn2	metabolic panel	(none)	blood urea nitrogen (serum BUN), naive [mg/dL] BUN 36131	inbred	15	m	7wks	N=3

Rusyn2:32	Rusyn2	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), control group [mg/dL] BUN_ctrl 36132 time: 2h 8h 24h	inbred	16	m	7wks	N=3

Rusyn2:37	Rusyn2	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), treated group [mg/dL] BUN_tce 36137 time: 2h 8h 24h	inbred	16	m	7wks	N=3

Rusyn2:41	Rusyn2	organ weights	(none)	liver weight as percent of body weight, naive [ratio (local parameter)] LW_adj 36141	inbred	14	m	7wks	N=3

Rusyn2:42	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=2h (local parameter) [%] LW_adj2_ctrl 36142	inbred	16	m	7wks	N=3

Rusyn2:43	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=8h (local parameter) [%] LW_adj8_ctrl 36143	inbred	17	m	7wks	N=3

Rusyn2:44	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=24h (local parameter) [%] LW_adj24_ctrl 36144	inbred	16	m	7wks	N=3

Rusyn2:47	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=2h (local parameter) [%] LW_adj2_tce 36147	inbred	16	m	7wks	N=3

Rusyn2:48	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=8h (local parameter) [%] LW_adj8_tce 36148	inbred	17	m	7wks	N=3

Rusyn2:49	Rusyn2	organ weights	(none)	liver weight as percent of body weight, t=24h (local parameter) [%] LW_adj24_tce 36149	inbred	16	m	7wks	N=3

Rusyn2:67	Rusyn2	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3

Rusyn2:75	Rusyn2	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_tce 36175 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3

Rusyn2:85	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] DCV_cysteine_tce 36185 time after treatment: 2h 8h 24h	inbred	16	m	7wks	N=2

Rusyn2:95	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] DCV_glutathione_tce 36195 time after treatment: 2h 8h 24h	inbred	17	m	7wks	N=2

Rusyn2: Effects of trichloroethylene in males of 17 inbred mouse strains (2010)