Richfield1: Behavioral, neurochemical, neuroanatomical, and neurotoxicological survey of the midbrain dopamine system in males of 15 inbred strains of mice (2003)

Mhyre TR, Chesler EJ, Thiruchelvam M, Lungu C, Cory-Slechta DA, Fry JD, Richfield EK. Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice. Genes Brain Behav. 2005 Jun;4(4):209-28.   PubMed 15924554  


       
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Participants Eric K Richfield       Environmental and Occupational Health Science Institute Piscataway, NJ
Timothy R Mhyre       University of Rochester School of Medicine and Dentistry Rochester, NY
Deborah A Cory-Slechta       Environmental and Occupational Health Science Institute Piscataway, NJ
Mona Thiruchelvam       Environmental and Occupational Health Science Institute Piscataway, NJ
Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: Fry J, Lungu C
ContactEric K Richfield     ekr@eohsi.rutgers.edu
AcknowledgementsFunding provided by NIH ES11839, DOD DAMD17-98-1-8628.
Project type Phenotype strain survey data set
MPD identifiersRichfield1     MPD:145
Data changelog 2 updates/corrections.       Initial release date: 04/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Locomotor behavioral parameters and neurotransmitter concentrations related to the midbrain dopamine system were assessed. The midbrain dopamine system is an important mediator of both normal and pathologic behaviors in many species, including humans. As such, it has received considerable attention regarding its roles in aspects of motor activity, attention, motivation/reward, and cognition.

Summary of procedures that were conducted
• open field test Locomotor activity. 3 day trials. 45 min sessions.
• neurotransmitter quantification Neurotransmitters. Molecular measures.
Mice: inbred   15 strains   ♂   age 7-9wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Richfield1 14501 open field test (none) horizontal beam breaks   [n]     counts (45min session):    daily avg    day1    day2    day3 inbred 15 m 7-9wks N=10
    Richfield1 14504 open field test (none) ambulatory activity   [n]     counts (45min session):    daily avg    day1    day2    day3 inbred 15 m 7-9wks N=10
    Richfield1 14507 open field test (none) vertical beam breaks (rearing)   [n]     counts (45min session):    daily avg    day1    day2    day3 inbred 15 m 7-9wks N=7
    Richfield1 14511 open field test (none) horizontal beam breaks per minute   [n/min]  horiz_rate inbred 15 m 7-9wks N=10
    Richfield1 14512 open field test (none) long-term habituation, change in horizontal activity over days 1-3   [n/d]  horiz_long_habit inbred 15 m 7-9wks N=10
    Richfield1 14513 open field test (none) short-term habituation, change in horizontal activity over 45min, day 3   [n/min]  horiz_short_habit inbred 15 m 7-9wks N=10
    Richfield1 14515 open field test (none) rate of ambulatory activity per minute   [n/min]  amb_rate inbred 15 m 7-9wks N=10
    Richfield1 14516 open field test (none) long-term habituation, change in ambulatory activity over days 1-3   [n/d]  amb_long_habit inbred 15 m 7-9wks N=10
    Richfield1 14517 open field test (none) short-term habituation, change in ambulatory activity over 45 min, day 3   [n/min]  amb_short_habit inbred 15 m 7-9wks N=10
    Richfield1 14519 open field test (none) vertical beam breaks per minute   [n/min]  vert_rate inbred 15 m 7-9wks N=7
    Richfield1 14520 open field test (none) long-term habituation, change in vertical activity over days 1-3   [n/d]  vert_long_habit inbred 15 m 7-9wks N=7
    Richfield1 14521 open field test (none) short-term habituation, change in vertical activity over 45 min, day 3   [n/min]  vert_short_habit inbred 15 m 7-9wks N=7
    Richfield1 14522 neurotransmitter quantification (none) dopamine (DA), ng per mg total protein   [ratio]  DA inbred 15 m 7-9wks N=10
    Richfield1 14523 neurotransmitter quantification (none) 3,4-dihydroxyphenylacetic acid (DOPAC), ng per mg total protein   [ratio]  DOPAC inbred 15 m 7-9wks N=10
    Richfield1 14524 neurotransmitter quantification (none) 4-hydroxy-3-methoxyphenylacetic acid (HVA), ng per mg total protein   [ratio]  HVA inbred 15 m 7-9wks N=10
    Richfield1 14525 neurotransmitter quantification (none) serotonin (5HT), ng per mg total protein   [ratio]  5HT inbred 15 m 7-9wks N=10
    Richfield1 14526 neurotransmitter quantification (none) dopamine turnover ([DOPAC]/[DA])   [ratio]  DA_turnover1 inbred 15 m 7-9wks N=10
    Richfield1 14527 neurotransmitter quantification (none) dopamine turnover ([DOPAC] + [HVA]/[DA])   [ratio]  DA_turnover2 inbred 15 m 7-9wks N=10
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