Rhodes1: Exercise-induced hippocampal neurogenesis in adults of 12 diverse strains of mice (2010)

Clark PJ, Kohman RA, Miller DS, Bhattacharya TK, Brzezinska WJ, Rhodes JS. Genetic influences on exercise-induced adult hippocampal neurogenesis across 12 divergent mouse strains. Genes Brain Behav. 2011 Apr;10(3):345-53. doi: 10.1111/j.1601-183X.2010.00674.x. Epub 2011 Jan 12.   PubMed 21223504  


         

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Participants Justin S Rhodes       University of Illinois at Urbana-Champaign Champaign, IL
Peter J Clark       University of Illinois at Urbana-Champaign Champaign, IL
With: Kohman RA, Miller DS, Bhattacharya TK, Brezinska WJ
ContactJustin S Rhodes     jrhodes@illinois.edu     Lab web site
AcknowledgementsFunding provided by NIH MH083807, DA027487
Project type Phenotype strain survey data set
MPD identifiersRhodes1     MPD:346
Data changelog No updates/corrections.       Initial release date: 01/2011.
Formatted citation
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Mice were divided into 2 cohorts: 1) housed with a running wheel; 2) housed without a wheel. The purpose of this study was to quantitate exercise-induced neurogenesis. For the first 10 days, all mice received daily injections of BrdU to label dividing cells. After 43 days, neurogenesis was assessed immunohistochemically based on the number of BrdU cells co-expressing a neuronal cell marker in the hippocampus dentate gyrus. Daily locomotor activity and its effect on body weight were also recorded.

Summary of procedures that were conducted
• running wheel monitoring Locomotor activity. Exercise wheel group vs. control group. Distance per day.
• body weight Exercise wheel group vs. control group.
• microscopy Examination of hippocampus dentate gyrus. Exercise wheel group vs. control group.
Mice: inbred   12 strains   ♀♂   age 8-15wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Rhodes1 34601 running wheel monitoring exercise locomotor activity   [km/d]     control    with running wheel inbred 12 both 8-15wks N=4
    Rhodes1 34603 microscopy exercise hippocampus: volume of dentate gyrus   [mm3]     control    with running wheel inbred 12 both 15wks N=4
    Rhodes1 34605 microscopy exercise hippocampus: number of new neurons in dentate gyrus   [n]     control    with running wheel inbred 12 both 15wks N=4
    Rhodes1 34607 microscopy exercise hippocampus: density of new neurons in dentate gyrus   [n/mm3]     control    with running wheel inbred 12 both 15wks N=4
    Rhodes1 34609 body weight exercise final body weight   [g]     control    with running wheel inbred 12 both 15wks N=4
    Rhodes1 34611 body weight exercise change in body weight   [ratio]     control    with running wheel inbred 12 both 15wks N=4
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