Petryshen1: Prepulse inhibition in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (males) (2009)
Leussis MP, Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P, Petryshen TL. Genomic survey of prepulse inhibition in mouse chromosome substitution strains.
Genes Brain Behav. 2009 Nov;8(8):806-16. Epub 2009 Jul 21.
Notes
[MPD curation comment]: Since acoustic startle response is highly dependant on hearing ability, it is noteworthy that C57BL/6J strain is homozygous for Cdh23ahl (cadherin 23, otocadherin) on mouse chromosome 10. The age related hearing loss 1 (ahl) mutation, on this background results in progressive hearing loss with onset after 10 mo of age. Additionally, A/J is also homozygous for Cdh23ahl which on A/J background results in progressive hearing loss with onset between 3 and 5 mo of age. While it is possible that mice from the B6.A-Chr10 strain have the least ASR performance due to one of these hearing loss loci, mice were tested prior to the known onset of hearing loss for these loci.
[MPD curation comment]: Since acoustic startle response is highly dependant on hearing ability, it is noteworthy that C57BL/6J strain is homozygous for Cdh23ahl (cadherin 23, otocadherin) on mouse chromosome 10. The age related hearing loss 1 (ahl) mutation, on this background results in progressive hearing loss with onset after 10 mo of age. Additionally, A/J is also homozygous for Cdh23ahl which on A/J background results in progressive hearing loss with onset between 3 and 5 mo of age. While it is possible that mice from the B6.A-Chr10 strain have the least ASR performance due to one of these hearing loss loci, mice were tested prior to the known onset of hearing loss for these loci.
Petryshen1 downloads
• Download Petryshen1 project data set animal data, as uploaded
• Download Petryshen1 animal data matrix with factor-related expansion applied as necessary
• Download Petryshen1 strain means, SD, N, etc. one row per strain/sex/measure
• Download Petryshen1 project data set animal data, as uploaded
• Download Petryshen1 animal data matrix with factor-related expansion applied as necessary
• Download Petryshen1 strain means, SD, N, etc. one row per strain/sex/measure
Ontology terms mapped to Petryshen1 measures:
| Investigators |
Tracey L Petryshen Harvard Medical School, Boston, MA Melanie P Leussis Harvard Medical School, Boston, MA |
| Participants | Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P |
| Contact | Tracey L Petryshen petryshen@chgr.mgh.harvard.edu
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| Acknowledgements | Funding provided by NIH MH071673, RR12305, MH0703930; Stanley Medical Research Institute, National Alliance for Research on Schizophrenia and Depression, Canadian Institutes of Health of Research |
| Phenotype strain survey data set | |
| MPD identifiers | Petryshen1 MPD:347 |
| 1 update/correction. Initial release date: 10/2010. | |
|
Click above to copy-paste the entire citation for this MPD web page. |
An investigation of QTLs for prepulse inhibition and acoustic startle
response. Acoustic startle
was measured for various stimuli: a 120 dB pulse alone, or a pulse
preceded by different prepulse intensities (70, 75, 80, 85 dB). Prepulse
inhibition was calculated from the pulse alone and prepulse-pulse
startle data. Animals were evaluated using the Kinder Scientific startle
reflex measurement system.
Procedures conducted:
Procedures conducted:
| Acoustic startle response, prepulse inhibition. |
