Petryshen1: Prepulse inhibition in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (males) (2009)

Leussis MP, Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P, Petryshen TL. Genomic survey of prepulse inhibition in mouse chromosome substitution strains. Genes Brain Behav. 2009 Nov;8(8):806-16. Epub 2009 Jul 21.   PubMed 19694817  


         
Notes
[MPD curation comment]: Since acoustic startle response is highly dependant on hearing ability, it is noteworthy that C57BL/6J strain is homozygous for Cdh23ahl (cadherin 23, otocadherin) on mouse chromosome 10. The age related hearing loss 1 (ahl) mutation, on this background results in progressive hearing loss with onset after 10 mo of age. Additionally, A/J is also homozygous for Cdh23ahl which on A/J background results in progressive hearing loss with onset between 3 and 5 mo of age. While it is possible that mice from the B6.A-Chr10 strain have the least ASR performance due to one of these hearing loss loci, mice were tested prior to the known onset of hearing loss for these loci.

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Participants Tracey L Petryshen       Harvard Medical School Boston, MA
Melanie P Leussis       Harvard Medical School Boston, MA
With: Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP Jr, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P
ContactTracey L Petryshen     petryshen@chgr.mgh.harvard.edu     Lab web site
AcknowledgementsFunding provided by NIH MH071673, RR12305, MH0703930; Stanley Medical Research Institute, National Alliance for Research on Schizophrenia and Depression, Canadian Institutes of Health of Research
Project type Phenotype strain survey data set
MPD identifiersPetryshen1     MPD:347
Data changelog 1 update/correction.       Initial release date: 10/2010.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of QTLs for prepulse inhibition and acoustic startle response. Acoustic startle was measured for various stimuli: a 120 dB pulse alone, or a pulse preceded by different prepulse intensities (70, 75, 80, 85 dB). Prepulse inhibition was calculated from the pulse alone and prepulse-pulse startle data. Animals were evaluated using the Kinder Scientific startle reflex measurement system.

Summary of procedures that were conducted
• acoustic startle test Acoustic startle response, prepulse inhibition.
Mice: B6.A consomic   22 strains   ♂   age 7-9wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Petryshen1 34701 acoustic startle test (none) acoustic startle response (ASR) without
prepulse stimulus presented   [N]
    no tone    120dB tone
B6.A consomic 22 m 7-9wks N=23
    Petryshen1 34703 acoustic startle test (none) acoustic startle response (ASR) evoked by 120 dB tone
under varying prepulse stimulus   [N]
    70dB    75dB    80dB    85dB
B6.A consomic 22 m 7-9wks N=23
    Petryshen1 34707 acoustic startle test (none) percent prepulse inhibition (PPI) evoked by 120 dB tone
under varying prepulse stimulus   [%]
    70dB    75dB    80dB    85dB
B6.A consomic 22 m 7-9wks N=23
    All boxes