Payseur1: Gough Island x WSB intercross to investigate body weight (2015)

Gray MM, Parmenter MD, Hogan CA, Ford I, Cuthbert RJ, Ryan PG, Broman KW, Payseur BA. Genetics of Rapid and Extreme Size Evolution in Island Mice. Genetics. 2015 Sep;201(1):213-28. doi: 10.1534/genetics.115.177790. Epub 2015 Jul 20.   PubMed 26199233     FullText


     
Payseur1 downloads
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Participants Bret A Payseur       University of Wisconsin Madison, WI
With: Gray MM, Parmenter MD, Hogan CA, Ford I, Cuthbert RJ, Ryan PG, Broman KW
ContactBret A Payseur     payseur@wisc.edu
AffiliationChurchill Group QTL Archive
AcknowledgementsGrant: This project was supported by National Institutes of Health grant R01GM100426A (to BAP), NIH National Research Service Award 1F32GM090685 (to MMG), and a National Science Foundation graduate research fellowship (to MDP).
Project type QTL Archive data set
MPD identifiersPayseur1     MPD:539
Data changelog No updates/corrections.       Initial release date: 01/2016.
The mice on the remote Gough Island evolved the largest body size among wild house mice from around the world. Through comparisons with a smaller-bodied wild-derived strain from the same subspecies (WSB/EiJ), we demonstrated that Gough Island mice achieve their exceptional body weight primarily by growing faster during the 6 weeks after birth. We used genetic mapping in large F2 intercrosses between Gough Island mice and WSB/EiJ to identify quantitative trait loci (QTL) responsible for the evolution of 16-week weight trajectories.


QTL data set parameters:
Progenitor strains wild Gough Island mice     WSB/EiJ    
Cross typeF2 intercross
Population size 594 ♀     618 ♂
Age1-16wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Payseur1 53901 body weight (none) raw body weight, age 1wk to age 16wks (16 phenotypes)   [g]  wkN QTL population both 1-16wks N=606
Payseur1 53921 body weight (none) smoothed body weights, age 1wk to age 16wks (16 phenotypes)   [g]  wkN_sm QTL population both 1-16wks N=606
Payseur1 53941 body weight (none) estimated 1st derivative of body weight, age 1wk to age 16wks (16 phenotypes)   [g]  wkN_deriv QTL population both 1-16wks N=606



Project / data set:   Payseur1     a.k.a. Payseur_2015
Excel file:   Data_Description_Payseur2015.xlsx
CSV file:   Payseur2015_goughF2.csv
Large zipped data set:   goughF2.zip
Readme / text file:   readme_Payseur2015.txt