Palmer1: Survey of innate anxiety-like behavior and fear conditioning in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (19 strains) (2007)

Ponder CA, Munoz M, Gilliam TC, Palmer AA. Genetic architecture of fear conditioning in chromosome substitution strains: relationship to measures of innate (unlearned) anxiety-like behavior. Mamm Genome. 2007 Apr;18(4):221-8. Epub 2007 May 10.   PubMed 17492333  


       
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Participants Abraham Palmer       University of Chicago Chicago, IL
Christine A Ponder       Rockefeller University New York, NY
Michealanne Munoz       University of Chicago Chicago, IL
T Conrad Gilliam       University of Chicago Chicago, IL
ContactAbraham Palmer     aap@uchicago.edu     Lab web site
AcknowledgementsFunding provided by NIH MH70933, GM07088; National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award
Project type Phenotype strain survey data set
MPD identifiersPalmer1     MPD:255
Data changelog No updates/corrections.       Initial release date: 09/2007.
Formatted citation
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An investigation of fear-conditioned behavior during re-exposure to a specific context and tone.

Summary of procedures that were conducted
• fear conditioning test Innate anxiety-like behavior and contextual fear conditioning.
Mice: B6.A consomic   19 strains including progenitors   ♀♂   age 10wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Palmer1 25501 fear conditioning test (none) time freezing before exposure to shock, from 30-180 s, day 1   [s]  pretraining_freezing B6.A consomic w/par 19 both 7-12wks N=11
    Palmer1 25503 fear conditioning test (none) time freezing in context with 24h history and exposure to shock, from 30-180s, day 2   [s]  freezing_to_context B6.A consomic w/par 19 both 7-12wks N=11
    Palmer1 25504 fear conditioning test (none) time freezing in altered context (no tone) with 48h history and exposure to shock, from 30-180s, day 3   [s]  freezing_altered B6.A consomic w/par 19 both 7-12wks N=11
    Palmer1 25505 fear conditioning test (none) time freezing in altered context during 30 s in between 2 tones, day 3   [s]  freezing_btw_tones B6.A consomic w/par 19 both 7-12wks N=11
    Palmer1 25506 fear conditioning test (none) average time freezing during two 30 s tones in altered context, day 3   [s]  freezing_to_tones B6.A consomic w/par 19 both 7-12wks N=11
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