Paigen1: Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions) (2000)

Paigen B, Bouchard G, Carey MC   With: Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H

       
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Participants Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Guylaine Bouchard       Hopital Ste-Justine Montreal, Quebec CANADA
Martin C Carey       Harvard Medical School Boston, MA
With: Johnson D, Tovbina M, Silva A, Carver T, Tracy T, McFarland C, Archer J, Whitmore H
ContactBeverly Paigen     bev.paigen@jax.org
AffiliationJackson Laboratory Heart, Lung, and Blood Center (HLB)
Part of a series: • Inbred strains   (this project) Paigen1
• Obesity mutant strains   see Paigen3
AcknowledgementsFunding provided by NIH DK51568, NHLBI PGA HL66611, DK36588, DK34854, DK52911; Medical Research Council of Canada

Generous funds from Aventis Pharmaceuticals Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersPaigen1     MPD:29
Data changelog 8 updates/corrections.       Initial release date: 02/2001.
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All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured. After sac, a pathology review of livers and gallbladders was conducted. A collection of liver images is available as part of this project.

Summary of procedures that were conducted
• body weight Baseline vs. high-fat diet for 8wks.
• lipid profile Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet.
• metabolic panel Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast.
• histopathology Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet.
• organ dimensions Gallbladder volume after 8wks on high-fat diet.
• organ weights Liver weight after 8wks on high-fat diet.
Mice: inbred   44 strains   ♀♂   age 15-19wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Paigen1 2905 body weight high fat diet body weight   [g]     start    after 8wks on diet    Δchange inbred 38 both 7-11wks N=10
    Paigen1 2907 organ weights high fat diet  8wks liver weight at sacrifice   [g]  liverweight inbred 43 both 15-19wks N=9
    Paigen1 2908 organ dimensions high fat diet  8wks gallbladder volume   [µL]  gbvol inbred 43 both 15-19wks N=8
    Paigen1 2909 histopathology high fat diet  8wks mucin (score: 0-4)   [score]  mucin inbred 43 both 15-19wks N=9
    Paigen1 2910 histopathology high fat diet  8wks arc (score: 0-4)   [score]  arc inbred 43 both 15-19wks N=9
    Paigen1 2911 histopathology high fat diet  8wks filaments (score: 0-4)   [score]  filaments inbred 43 both 15-19wks N=9
    Paigen1 2912 histopathology high fat diet  8wks small liquid crystals (score: 0-4)   [score]  smallLC inbred 43 both 15-19wks N=9
    Paigen1 2913 histopathology high fat diet  8wks aggregated liquid crystals (score: 0-4)   [score]  agLC inbred 43 both 15-19wks N=9
    Paigen1 2914 histopathology high fat diet  8wks fused liquid crystals (score: 0-4)   [score]  fusedLC inbred 43 both 15-19wks N=9
    Paigen1 2915 histopathology high fat diet  8wks cholesterol monohydrate crystals (score: 0-4)   [score]  ChMC inbred 43 both 15-19wks N=9
    Paigen1 2916 histopathology high fat diet  8wks number of sandy stones   [n]  sandysto inbred 43 both 15-19wks N=9
    Paigen1 2917 histopathology high fat diet  8wks number of true gallstones   [n]  gs inbred 43 both 15-19wks N=9
    Paigen1 2918 histopathology high fat diet  8wks number of sandy plus true stones   [n]  nstones inbred 43 both 15-19wks N=9
    Paigen1 2919 histopathology high fat diet  8wks presence of stones (score: 1=present, 0=absent)   [score]  st_pres inbred 43 both 15-19wks N=9
    Paigen1 2920 lipid profile high fat diet  8wks total cholesterol (plasma)   [mg/dL]  totalCh inbred 43 both 15-19wks N=9
    Paigen1 2921 lipid profile high fat diet  8wks HDL cholesterol (plasma)   [mg/dL]  HDL_Ch inbred 43 both 15-19wks N=9
    Paigen1 2922 lipid profile high fat diet  8wks plasma cholesterol not in the HDL fraction   [mg/dL]  nonHDL_Ch inbred 43 both 15-19wks N=8
    Paigen1 2923 lipid profile high fat diet  8wks percent of total plasma cholesterol in HDL fraction   [%]  pctHDL_TCH inbred 43 both 15-19wks N=8
    Paigen1 2924 metabolic panel high fat diet  8wks alanine transaminase (plasma ALT)   [IU/L]  ALT inbred 43 both 15-19wks N=8
    Paigen1 2925 metabolic panel high fat diet  8wks bile salts (plasma)   [µmol/L]  bilesalts inbred 43 both 15-19wks N=8
    Paigen1 2926 lipid profile high fat diet  8wks hepatic cholesterol concentration (free per g liver)   [mg]  freeHCC inbred 43 both 15-19wks N=6
    Paigen1 2927 lipid profile high fat diet  8wks hepatic cholesterol concentration (esterified per g liver)   [mg]  estHCC inbred 43 both 15-19wks N=6
    Paigen1 2928 lipid profile high fat diet  8wks hepatic cholesterol concentration (total per g liver)   [mg]  totHCC inbred 43 both 15-19wks N=9
    Paigen1 2929 lipid profile high fat diet  8wks hepatic cholesterol concentration (free to esterified ratio)   [ratio]  free_to_est inbred 43 both 15-19wks N=6
    Paigen1 2930 histopathology high fat diet  8wks microvacuoles (score: 0-4)   [score]  microvacs inbred 43 both 15-19wks N=3
    Paigen1 2931 histopathology high fat diet  8wks macrovacuoles (score: 0-4)   [score]  macrovacs inbred 43 both 15-19wks N=3
    Paigen1 2932 histopathology high fat diet  8wks inflammation (score: 0-4)   [score]  inflammation inbred 43 both 15-19wks N=3
    Paigen1 2936 histopathology high fat diet  8wks fatty streak aortic lesion size   [µm2]  aortic_lesion inbred 44 both 15-19wks N=8
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