Nelson1: Effects of dietary restriction on body composition and lifespan: life extension and life shortening in 44 ILSXISS recombinant inbred strains of mice (2010)

Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92-5. Epub 2009 Oct 30.   PubMed 19878144  

Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell. 2011 Aug;10(4):629-39. doi: 10.1111/j.1474-9726.2011.00702.x. Epub 2011 Apr 25.   PubMed 21388497  


       
Nelson1 downloads
• Download Nelson1 project data set     one row per animal, one column per trait
• Download Nelson1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants James F Nelson       University of Texas Health Science Center San Antonio, TX
Thomas E Johnson       University of Colorado Boulder, CO
With: Liao C-Y, Rikke BA, Gelfond J, Diaz V
ContactJames F Nelson     nelsonj@uthscsa.edu     Lab web site
AcknowledgementsFunding provided by NIH AG024354; Ellison Medical Foundation; Glenn Foundation
Project type Phenotype strain survey data set
MPD identifiersNelson1     MPD:341
Data changelog 1 update/correction.       Initial release date: 07/2010.
Formatted citation
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Two cohorts: 1) control mice fed ad libitum, and 2) test mice subjected to 40% dietary restriction (60% of ad libitum diet). Dietary restriction started at 2-5 mo of age. All mice from both cohorts were weighed and assessed for body composition at 15-17 mo of age. Lifespan data was collected.

Summary of procedures that were conducted
• body weight Restricted diet vs. ad libitum diet.
• NMR Body mass, fat mass, lean mass. Restricted diet vs. ad libitum diet.
• colony observation Life span comparison. Restricted diet vs. ad libitum diet.
Mice: ILSXISS   44 strains   ♀♂   age max lifespan   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Nelson1 34101 body weight restricted diet body weight   [g]     control    DR diet ILSXISS 41 both 65-74wks N=4
    Nelson1 34103 NMR restricted diet lean tissue mass, head included   [g]     control    DR diet ILSXISS 41 both 65-74wks N=4
    Nelson1 34105 NMR restricted diet fat tissue mass, head included   [g]     control    DR diet ILSXISS 41 both 65-74wks N=4
    Nelson1 34107 NMR restricted diet percent fat, whole body with head   [%]     control    DR diet ILSXISS 41 both 65-74wks N=4
    Nelson1 34109 colony observation restricted diet lifespan   [d]     control    DR diet ILSXISS 41 both varies N=5
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