Nadeau2: Diet effects on body weight and metabolic traits in the C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution panel (males) (2015)

Riordan JD, Croniger CM, Sinasac DS, Nadeau JH

       
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Participants Jesse D Riordan       Pacific Northwest Research Institute Seattle, WA
Colleen M Croniger       Case Western Reserve University School of Medicine Cleveland, OH
David S Sinasac       University of Calgary Calgary, AB CANADA
Joseph H Nadeau       Case Western Reserve University School of Medicine Cleveland, OH
ContactJoseph H Nadeau     jhn4@case.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersNadeau2     MPD:530
Data changelog No updates/corrections.       Initial release date: 09/2015.
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Summary of procedures that were conducted
• body size and weight Body weight, size, and body mass index after 16wks on high-fat high-sucrose diet.
• metabolic panel Glucose, insulin, insulin resistance after 16wks of high-fat high-sucrose diet. 16h fast.
• lipid profile Cholesterol, triglycerides. 16h fast, plasma. Hepatic triglycerides.
• organ weights Liver weight after 16wks of high-fat high-sucrose diet. 16h fast.
Mice: B6.A consomic   24 strains including progenitors   ♂   age 5, 21 wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Nadeau2 53001 body size and weight high fat high sucrose diet body weight   [g]     baseline    after 16wks on diet    Δchange B6.A consomic w/par 24 m 5wks N=39
    Nadeau2 53011 body size and weight high fat high sucrose diet  16wks body length   [cm]  body_length B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53012 body size and weight high fat high sucrose diet  16wks body mass index (BMI)   [g/cm2]  BMI B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53021 metabolic panel high fat high sucrose diet  16wks glucose (blood GLU, 16h fast)   [mmol/L]  GLU B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53022 metabolic panel high fat high sucrose diet  16wks insulin (plasma, 16h fast)   [pmol/L]  INS B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53023 metabolic panel high fat high sucrose diet  16wks homeostasis model assessment insulin resistance (HOMA-IR, 16h fast)  HOMA_IR B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53041 lipid profile high fat high sucrose diet  16wks total cholesterol (plasma CHOL)   [mmol/L]  CHOL B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53042 lipid profile high fat high sucrose diet  16wks triglycerides (plasma TG, 16h fast)   [mmol/L]  TG B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53051 organ weights high fat high sucrose diet  16wks liver weight   [g]  liver_wt B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53052 lipid profile high fat high sucrose diet  16wks liver triglycerides (mg/g liver)  liver_TG B6.A consomic w/par 24 m 21wks N=39
    Nadeau2 53053 lipid profile high fat high sucrose diet  16wks total liver triglycerides   [g]  liver_TG_tot B6.A consomic w/par 24 m 21wks N=39
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