Moy1: Investigation of autism-relevant behaviors in males of 17 inbred strains of mice (2008)

Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res. 2007 Jan 10;176(1):4-20. Epub 2006 Sep 12.   PubMed 16971002     FullText

Moy SS, Nadler JJ, Young NB, Nonneman RJ, Segall SK, Andrade GM, Crawley JN, Magnuson TR. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res. 2008 Aug 5;191(1):118-29. Epub 2008 Mar 21.   PubMed 18440079     FullText


       
Moy1 downloads
• Download Moy1 project data set     one row per animal, one column per trait
• Download Moy1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Sheryl S Moy       University of North Carolina Chapel Hill, NC
Jacqueline N Crawley       National Institute of Mental Health Bethesda, MD
Jean M Lauder       University of North Carolina Chapel Hill, NC
Jessica J Nadler       University of North Carolina Chapel Hill, NC
David W Threadgill       Texas A&M University College Station, TX
Terry R Magnuson       University of North Carolina Chapel Hill, NC
With: Young NB, Perez A, Nonneman RJ
ContactTerry R Magnuson     trm4@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH MH66418, HD03110; NIMH Intramural Research Program

Dr. Joseph Piven, Director of the Carolina Institute for Developmental Disabilities, provided valuable insights throughout the project.
Project type Phenotype strain survey data set
MPD identifiersMoy1     MPD:301
Data changelog No updates/corrections.       Initial release date: 02/2009.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of autism-modelling possibilities. The hallmark signs of human autism include aberrant social interactions, deficits in communication, and rigid, repetitive behaviors. Autistic-like behaviors were assessed in mice using an automated 3-chambered social test apparatus. Shortly after a period of habituation to the social test box, mice were evaluated for sociability in the presence of an unfamiliar mouse,
Sociability test   Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (an unfamiliar mouse) versus a novel object (an empty wire cage).

Preference for social novelty test   Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (a newly-presented unfamiliar mouse) versus a former social stimulus (an already-investigated mouse). and then tested for social novelty preference by adding a second, less-familiar conspecific mouse to the apparatus.

Summary of procedures that were conducted
• three chamber assay Sociability and preference for social novelty. Autism-relevant behaviors.
Mice: inbred   17 strains   ♂   age 6-7wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Moy1 30101 three chamber assay (none) time spent in chamber with stranger 1 (a novel mouse), 10 min test   [s]  DurSTR1_soc inbred 17 m 6-7wks N=22
    Moy1 30102 three chamber assay (none) time spent in chamber with empty cage (a novel object), 10 min test   [s]  DurOBJ_soc inbred 17 m 6-7wks N=22
    Moy1 30103 three chamber assay (none) time spent in center chamber, 10 min test   [s]  DurCEN_soc inbred 17 m 6-7wks N=22
    Moy1 30104 three chamber assay (none) time spent sniffing cage with stranger1 (a novel mouse), 10 min test   [s]  SnSTR1_soc inbred 17 m 6-7wks N=22
    Moy1 30105 three chamber assay (none) time spent sniffing empty cage (a novel object), 10 min test   [s]  SnOBJ_soc inbred 17 m 6-7wks N=22
    Moy1 30106 three chamber assay (none) number of entries into chamber with stranger1 (a novel mouse), 10 min test   [n]  EntSTR1_soc inbred 17 m 6-7wks N=22
    Moy1 30107 three chamber assay (none) number of entries into chamber with empty cage (a novel object), 10 min test   [n]  EntOBJ_soc inbred 17 m 6-7wks N=22
    Moy1 30108 three chamber assay (none) time spent in chamber with stranger1 (former novel mouse), 10 min test   [s]  DurSTR1_nov inbred 17 m 6-7wks N=23
    Moy1 30109 three chamber assay (none) time spent in chamber with stranger 2 (a second novel mouse), 10 min test   [s]  DurSTR2_nov inbred 17 m 6-7wks N=23
    Moy1 30110 three chamber assay (none) time spent in center chamber, 10 min test   [s]  DurCEN_nov inbred 17 m 6-7wks N=23
    Moy1 30121 three chamber assay (none) time spent sniffing cage with stranger1 (former novel mouse), 10 min test   [s]  SnSTR1_nov inbred 17 m 6-7wks N=22
    Moy1 30122 three chamber assay (none) time spent sniffing cage with novel stranger2 (a second novel mouse), 10 min test   [s]  SnSTR2_nov inbred 17 m 6-7wks N=22
    Moy1 30123 three chamber assay (none) number of entries into chamber with stranger1 (former novel mouse), 10 min test   [n]  EntSTR1_nov inbred 17 m 6-7wks N=23
    Moy1 30124 three chamber assay (none) number of entries into chamber with stranger2 (a second novel mouse), 10 min test   [n]  EntSTR2_nov inbred 17 m 6-7wks N=23
    All boxes             To see more rows use the paging control at top.