Mogil1: Investigation of basal nociception in males of 12 inbred strains of mice (2002)

References   (chronological)

1.   Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Devor M. Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain. 1999 Mar;80(1-2):67-82.   PubMed 10204719  

2.   Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Devor M. Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain. 1999 Mar;80(1-2):83-93.   PubMed 10204720  

3.   Lariviere WR, Wilson SG, Laughlin TM, Kokayeff A, West EE, Adhikari SM, Wan Y, Mogil JS. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain. 2002 May;97(1-2):75-86.   PubMed 12031781  


         
Notes
For each strain/sex/measurement the following summary data were submitted: mean measurement value, N (usually a range such as "6-8"), and standard error of the measurement value.

Dec 2008: In order to use these data more effectively with MPD tools, where N was supplied as a range the lower N value is retained in the MPD database.


Mogil1 downloads
• Download Mogil1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Jeffrey S Mogil       McGill University Montreal, Quebec CANADA
Marshall Devor       Hebrew University of Jerusalem Jerusalem ISRAEL
William R Lariviere       University of Pittsburgh School of Medicine Pittsburgh, PA
With: Wilson SG, Bon K, Lee SE, Chung K, Raber P, Pieper JO, Hain HS, Belknap JK, Hubert L, Elmer GI, Chung JM, Laughlin TM, Kokayeff A, West EE, Adhikari SM, Wan Y
ContactJeffrey S Mogil     jeffrey.mogil@mcgill.ca     Lab web site
AcknowledgementsFunding provided by NIH DA11394, DA11888, NS35057, NS31680, NS11255, DE12735; and by Fritz Thyssen Stiftung Foundation and the Hebrew University Center for Research on Pain, Fonds pour la Formation de Chercheurs et l'Aide a la Recherche of Quebec.
Project type Phenotype strain survey data set
MPD identifiersMogil1     MPD:22
Data changelog 2 updates/corrections.       Initial release date: 02/2001.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Summary of procedures that were conducted
• nociception assay Battery of tests for mechanical, chemical, thermal nociception.
Mice: inbred   12 strains   ♂   age 6-18wks   2 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Mogil1 2201 nociception assay (none) latency of nociceptive response, (53°C) hot plate test   [s]  HP inbred 11 m 6-18wks N=8
    Mogil1 2202 nociception assay (none) latency of heated hindpaw withdrawal, Hargreaves test   [s]  HT inbred 11 m 6-18wks N=6
    Mogil1 2203 nociception assay (none) latency of tail withdrawal, 49°C heat stimulation   [s]  TW_HOT1 inbred 11 m 6-18wks N=10
    Mogil1 2204 nociception assay (none) median 50% foot withdrawal threshold, Von Frey test   [mN]  VF inbred 11 m 6-18wks N=7
    Mogil1 2205 nociception assay (none) number of abdominal contrictions induced with acetic acid (i.p.), 20 min   [n]  AC_AA inbred 11 m 6-18wks N=6
    Mogil1 2206 nociception assay (none) number of abdominal constrictions induced with magnesium sulfate (i.p.), 5 min   [n]  AC_MS inbred 11 m 6-18wks N=6
    Mogil1 2207 nociception assay (none) percent hypersensitivity threshold to carrageenan-induced thermal hyperalgesia, treated and heated hindpaw withdrawal   [%]  CAR_HT inbred 11 m 6-18wks N=6
    Mogil1 2208 nociception assay (none) duration of nociceptive response to acute inflammation (early phase), 0-10 min post-formalin (s.q.) injection   [s]  F_early inbred 11 m 6-18wks N=7
    Mogil1 2209 nociception assay (none) duration of nociceptive response to subacute/chronic inflammation (late phase), 10-60 min post-formalin (s.q.) injection   [s]  F_late inbred 11 m 6-18wks N=7
    Mogil1 2210 nociception assay (none) autotomy (neuropathy) score (1-11) following hindlimb denervation   [score]  AUT inbred 11 m 6-18wks N=9
    Mogil1 2211 nociception assay (none) percent hypersensitivity threshold to Hargreaves test following peripheral nerve injury (PNI)   [%]  PNI_HT inbred 11 m 6-18wks N=6
    Mogil1 2212 nociception assay (none) median 50% foot withdrawal hypersensitivity threshold to von Frey test following peripheral nerve injury (PNI)   [mN]  PNI_VF inbred 11 m 6-18wks N=7
    Mogil1 2220 nociception assay (none) duration of nociceptive response to capsaicin   [s]  CAP inbred 12 m 6-18wks N=5
    Mogil1 2221 nociception assay (none) duration of nociceptive response to bee venom   [s]  BV inbred 12 m 6-18wks N=5
    Mogil1 2222 nociception assay (none) latency of nociception to heated tail following hindleg
acupuncture needles stimulation (analgesia), tail flick test   [s]
 TF
inbred 10 m 6-18wks N=21
    Mogil1 2223 nociception assay (none) latency of tail withdrawal, 47°C heat stimulation   [s]  TW_HOT2 inbred 12 m 6-18wks N=5
    Mogil1 2224 nociception assay (none) latency of tail withdrawal, -15°C cold stimulation   [s]  TW_COLD inbred 12 m 6-18wks N=5
    Mogil1 2225 nociception assay (none) percent hypersensitivity threshold to capsaicin-induced thermal hyperalgesia, tail withdrawal at 47°C   [%]  CAP_TW inbred 12 m 6-18wks N=5
    Mogil1 2226 nociception assay (none) percent hypersensitivity threshold to bee venom-induced thermal hyperalgesia (ipsilateral), treated and heated hindpaw withdrawal   [%]  BV_HT inbred 12 m 6-18wks N=5
    Mogil1 2227 nociception assay (none) percent hypersensitivity threshold to bee venom-induced thermal hyperalgesia (contralateral), untreated and heated hindpaw withdrawal   [%]  BV_HT_CON inbred 12 m 6-18wks N=5
    Mogil1 2228 nociception assay (none) latency of nociception to pinched tail   [s]  TC inbred 12 m 6-18wks N=7
    Mogil1 2229 nociception assay (none) percent hypersensitivity threshold to mechanical stimulation
following dynorphin treatment, von Frey test   [%]
 DYN_VF
inbred 7 m 6-18wks N=4
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