Mills1: Aging study: Chromosome instability and apoptosis in 30 inbred strains of mice (2008)

Mills K   With: Schultz D, Godfrey D, Alley T

       
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Participants Kevin Mills       The Jackson Laboratory Bar Harbor, ME
With: Schultz D, Godfrey D, Alley T
ContactKevin Mills     kevin.mills@jax.org     Lab web site
AffiliationJackson Laboratory Nathan Shock Center
AcknowledgementsFunding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersMills1     MPD:252
Data changelog 1 update/correction.       Initial release date: 09/2009.
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Summary of procedures that were conducted
• apoptosis assessment Aging study, 6mo, 12mo, 20mo.
• chromosome instability assessment Chromosome instability. Aging study, 6mo, 12mo, 20mo.
Mice: inbred   30 strains   ♀♂   age 6, 12, 20 mo   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Mills1 25205 apoptosis assessment (none) early apoptotic splenocytes   [%]     6mo    12mo    20mo inbred 7 both None N=3
    Mills1 25211 apoptosis assessment (none) late apoptotic splenocytes   [%]     6mo    12mo    20mo inbred 7 both None N=3
    Mills1 25217 apoptosis assessment (none) all apoptotic splenocytes   [%]     6mo    12mo    20mo inbred 7 both None N=3
    Mills1 25225 chromosome instability assessment (none) reticulocytes with micronuclei   [%]     6mo    12mo    20mo inbred 7 both None N=5
    Mills1 25231 chromosome instability assessment (none) red blood cells (RBC) with micronuclei   [%]     6mo    12mo    20mo inbred 7 both None N=5
    Mills1 25235 chromosome instability assessment (none) non-nucleated peripheral blood cells with micronuclei   [%]     6mo    12mo    20mo inbred 7 both None N=5
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