Metten2: Drug study: Alcohol withdrawal severity in males of 15 inbred strains of mice (2005)

Metten P, Crabbe JC. Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behav Neurosci. 2005 Aug;119(4):911-25.   PubMed 16187819  


       
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Participants Pamela Metten       Oregon Health & Science University Portland, OR
John C Crabbe       Oregon Health & Science University Portland, OR
ContactPamela Metten     mettenp@ohsu.edu
AcknowledgementsFunding provided by NIH AA10760, AA12714, AA06243, AA13519; Merit Review Grant Department of Veterans Affairs.

Acknowlegements: Dorow J, O'Leary T, Sibert J, Schlumbohm J for data collection; Zuraw J, Mordarski K, Cameron A, Yu C, Cotnam C, Best K, Sorensen M, Kliethermes C, for data analyses and presentation.
Project type Phenotype strain survey data set
MPD identifiersMetten2     MPD:195
Data changelog No updates/corrections.       Initial release date: 01/2007.
Formatted citation
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One group of mice was exposed to ethanol (EtOH) vapor in an inhalation chamber while the control group was not exposed to EtOH (air only). The investigators note that they consider the most important measurement in the study to be: "withdrawal severity during 0-25h (area under curve of HIC scores), aerolized EtOH normalized to controls" (see below).

Summary of procedures that were conducted
• body weight
• behavior observation Ethanol withdrawal severity and handling-induced convulsions.
Mice: inbred   15 strains   ♂   age 8-11wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Metten2 19501 body weight (none) body weight   [g]     start    Δchange after testing inbred 15 m 8-15wks N=20
    Metten2 19503 behavior observation ethanol peak handling-induced convulsion (HIC) score   [score]     control    ethanol    ethanol normalized to controls inbred 15 m 8-15wks N=10
    Metten2 19506 behavior observation ethanol  aerosolized latency to first handling-induced convulsions score used to calculate peak ethanol   [h]  peak_latency inbred 15 m 8-15wks N=11
    Metten2 19507 behavior observation ethanol  aerosolized withdrawal severity during 0-25h (area under curve of handling-induced convulsions scores)   [AUC]  withdrawal_EtOH inbred 15 m 8-15wks N=20
    Metten2 19508 behavior observation ethanol  aerosolized withdrawal severity during 0-25h (area under curve of handling-induced convulsions scores), normalized to controls   [AUC]  withdrawal_EtOHadj inbred 15 m 8-15wks N=11
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