Lyons3: Identification of QTLs to determine cholesterol levels in 129S1/SvImJ and RIIIS/J F2 intercross (2004)

Lyons MA, Korstanje R, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice. Physiol Genomics. 2004 Apr 13;17(2):114-21.   PubMed 14872007  


     
Lyons3 downloads
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Participants M A Lyons
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Korstanje R, Li R, Walsh KA, Carey MC, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH DK51568, DK36588, DK52911, DK34854, HL66611, CA34196; National Health and Medical Research Council of Australia (222913), American Physiological Society, American Liver Foundation
Project type QTL Archive data set
MPD identifiersLyons3     MPD:146
Data changelog No updates/corrections.       Initial release date: 07/2011.
An intercross of NZB/BlNJ and SM/J was generated to identify cholesterol gallstone susceptibility loci. F2 progeny were administered a high-fat (15%) diet for 18 wks and examined for gallstone formation. Gallstones were characterized qualitatively and quantitatively. Mice were fasted prior to sample collection. For detailed protocols see Lyons et al 2005.


QTL data set parameters:
Progenitor strains 129S1/SvImJ     RIIIS/J    
Cross direction notation(RIIIS x 129) F1 x (RIIIS x 129) F1; (129 x RIIIS) F1 x (129 x RIIIS) F1
Cross typeF2 reciprocal intercross
Population size 0 ♀     330 ♂
Age14-20wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Lyons3 14601 histopathology high fat diet  8 or 12wks weight of gallstones   [mg]  GS_wt QTL population m 14-20wks N=330
Lyons3 14602 histopathology high fat diet  8 or 12wks number of gallstones   [n]  GS_no QTL population m 14-20wks N=330
Lyons3 14603 histopathology high fat diet  8 or 12wks gallstone score (score 0=absent, 1=crystals only, 2=sandy or solid gallstones)   [score]  Score_1 QTL population m 14-20wks N=330
Lyons3 14604 histopathology high fat diet  8 or 12wks cholesterol monohydrate crystals, aggregates (score 0=absence, 1-4=severity)   [score]  AggChM QTL population m 14-20wks N=330
Lyons3 14605 histopathology high fat diet  8 or 12wks solid gallstones (score 0=absence, 4=severity)   [score]  Solid QTL population m 14-20wks N=330
Lyons3 14606 histopathology high fat diet  8 or 12wks sandy gallstones (score 0=absence, 1-4=severity)   [score]  Sandy QTL population m 14-20wks N=330
Lyons3 14607 histopathology high fat diet  8 or 12wks gallbladder mucin accumulation (score 0-3) 0=no mucin;1-3= mucin accumulation severity   [score]  Mucin QTL population m 14-20wks N=330
Lyons3 14608 organ dimensions high fat diet  8 or 12wks gallbladder volume   [μL]  GB_vol QTL population m 14-20wks N=330
Lyons3 14609 lipid profile high fat diet  8 or 12wks total lipoprotein cholesterol   [mg/dL]  Tot_Chol QTL population m 14-20wks N=330
Lyons3 14610 lipid profile high fat diet  8 or 12wks HDL cholesterol   [mg/dL]  HDL QTL population m 14-20wks N=330
Lyons3 14611 lipid profile high fat diet  8 or 12wks nonHDL cholesterol level   [mg/dL]  Non-HDL QTL population m 14-20wks N=330
To see more rows use the paging control at top.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Chol10   Chol11   Hdlq17   Hdlq18   Hdlq5   Nhdlq3  


Project / data set:   Lyons3     a.k.a. Lyons_2004
Excel file:   Data_Description_RIIISx129_Lyons2004.xlsx
CSV file:   Lyons2004_RIIISx129_B37_Data.csv
Readme / text file:   readme_Lyons2004.txt
QC plots, figures, etc.:   QCReport_Lyons2004.pdf