Loos2: Sheltering behavior and locomotor activity in males of 11 inbred strains of mice and within-strain variation of 8 of those strains (2016)

Loos M, Koopmans B, Aarts E, Maroteaux G, van der Sluis S; Neuro-BSIK Mouse Phenomics Consortium, Verhage M, Smit AB. Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. PLoS One. 2014 Sep 29;9(9):e108563. doi: 10.1371/journal.pone.0108563. eCollection 2014.   PubMed 25264768     FullText


       
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Participants Maarten Loos       Sylics Amsterdam NETHERLANDS
Bastijn Koopmans       Sylics Amsterdam NETHERLANDS
With: Aarts E, Maroteaux G, van der Sluis S, Verhage M, Smit AB, Neuro-BSIK Mouse Phenomics Consortium
ContactMaarten Loos     maarten.loos@sylics.com     Lab web site
AcknowledgementsFunding provided by Agentschap NL (NeuroBSIK Mouse Phenomics Consortium, BSIK03053); NeuroBasic PharmaPhenomics Consortium (LSH framework FES0908); Netherlands Organization for Scientific Research (NWO/MaGW: VIDI-452-12-014)
Project type Phenotype strain survey data set
MPD identifiersLoos2     MPD:540
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
This study aimed to determine the aspects of spontaneous mouse homecage behavior that are most influenced by genetic variation. Behavior was recorded for three consecutive days in a home-cage system by 24/7 overhead video tracking for each animal individually. Continuous video-tracking observations of sheltering behavior and locomotor activity were segmented into distinguishable behavioral elements, yielding a set of 115 behavioral parameters which demonstrated high dimensionality. Sixty-seven of those measurements have been accessioned here. Within-strain variation in behavior was also assessed. Selected measurements were log10 transformed by the investigators.

Summary of procedures that were conducted
• home cage monitoring Locomotor activity, sheltering, habituation. 3 day home-cage assessment.
Mice: inbred   11 strains   ♂   age 8-12wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Loos2 54001 home cage monitoring (none) bouts, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54003 home cage monitoring (none) cumulative duration of activity during dark phase, over 3 days of testing   [s]  activity_dur_DK inbred w/CC7 11 m 8-12wks N=35
    Loos2 54004 home cage monitoring (none) cumulative duration of activity during light phase, over 3 days of testing, log10 transformed   [log(s)]  activity_dur_LT inbred w/CC7 11 m 8-12wks N=35
    Loos2 54005 home cage monitoring (none) bouts, mean duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=34
    Loos2 54007 home cage monitoring (none) bouts, duration-habituation   [log(ratio)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54011 home cage monitoring (none) dark-light index describing difference in cumulative activity duration between light and dark phase, over 3 days of testing   [ratio]  activity_dur_DKLT_index inbred w/CC7 11 m 8-12wks N=35
    Loos2 54012 home cage monitoring (none) spout zone, duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54014 home cage monitoring (none) feeding zone, duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54016 home cage monitoring (none) onshelter zone, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54018 home cage monitoring (none) onshelter zone, duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54022 home cage monitoring (none) activity proportion, anticipation     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54024 home cage monitoring (none) activity proportion, response     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54026 home cage monitoring (none) spout zone, anticipation     dark    light inbred w/CC7 11 m 8-12wks N=32
    Loos2 54028 home cage monitoring (none) spout zone, response     dark    light inbred w/CC7 11 m 8-12wks N=28
    Loos2 54032 home cage monitoring (none) feeding zone, anticipation     dark    light inbred w/CC7 11 m 8-12wks N=32
    Loos2 54034 home cage monitoring (none) feeding zone, response     dark    light inbred w/CC7 11 m 8-12wks N=28
    Loos2 54036 home cage monitoring (none) onshelter zone, anticipation     dark    light inbred w/CC7 11 m 8-12wks N=32
    Loos2 54038 home cage monitoring (none) onshelter zone, response     dark    light inbred w/CC7 11 m 8-12wks N=28
    Loos2 54042 home cage monitoring (none) long movement, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54044 home cage monitoring (none) long movement, distance   [log(cm)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54046 home cage monitoring (none) average velocity of 95th percentile fastest long movement segments, over 3 days of testing, log10 transformed   [log(cm/s)]  long_move_max_vel inbred w/CC7 11 m 8-12wks N=35
    Loos2 54047 home cage monitoring (none) cut-off value to separate short and long movements, over 3 days of testing, log10 transformed   [log(cm)]  long_move_threshold inbred w/CC7 11 m 8-12wks N=35
    Loos2 54048 home cage monitoring (none) short movement, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54052 home cage monitoring (none) short movement, distance   [log(cm)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54054 home cage monitoring (none) long arrest, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54056 home cage monitoring (none) long arrest, duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54058 home cage monitoring (none) long arrest, mean duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54062 home cage monitoring (none) cut-off value to separate short and long arrests, over 3 days of testing, log10 transformed   [log(s)]  long_arrest_threshold inbred w/CC7 11 m 8-12wks N=35
    Loos2 54063 home cage monitoring (none) short arrest, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54065 home cage monitoring (none) short arrest, duration   [s]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54067 home cage monitoring (none) short arrest, mean duration   [log(s)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54071 home cage monitoring (none) long shelter visit, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54073 home cage monitoring (none) long shelter visit, duration   [s]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54075 home cage monitoring (none) fraction of shelter visits (sheltering) with duration longer than long shelter visit threshold, over 3 days of testing, log10 transformed   [log(ratio)]  long_shelter_fraction inbred w/CC7 11 m 8-12wks N=35
    Loos2 54076 home cage monitoring (none) cut-off value to separate intermediate and long shelter visits (sheltering), over 3 days of testing   [s]  long_shelter_threshold inbred w/CC7 11 m 8-12wks N=35
    Loos2 54077 home cage monitoring (none) short shelter visit, number   [log(n)]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54081 home cage monitoring (none) short shelter visit, duration   [s]     dark    light inbred w/CC7 11 m 8-12wks N=35
    Loos2 54083 home cage monitoring (none) cut-off value to separate short and intermediate shelter visits (sheltering), over 3 days of testing   [log(s)]  short_shelter_threshold inbred w/CC7 11 m 8-12wks N=35
    Loos2 54401 home cage monitoring (none) mean within-strain variation in 22 principal components representing 115 spontaneous behavioral parameters  within_strain_var inbred 8 m 8-12wks N=49
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