Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice. Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.   PubMed 19336673     FullText


     
Leiter2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants Ed Leiter       The Jackson Laboratory Bar Harbor, ME
With: Reifsnyder PC, Wallace R, Li R, King B, Churchill GC
ContactEd Leiter     ed.leiter@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196.
Project type QTL Archive data set
MPD identifiersLeiter2     MPD:240
Data changelog No updates/corrections.       Initial release date: 01/2008.
A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.


QTL data set parameters:
Progenitor strains 129S1/Sv.NOD-H2g7     NOD/ShiLtJ    
Cross direction notationNOD x (NOD x 129.H2g7)
Cross typeBackcross
Population size 310 ♀     0 ♂
NotesN2 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Leiter2 24001 health assessment (none) age of diabetes onset (dash = no diabetes)   [wks]  Onset QTL population f 14-40wks N=310
Leiter2 24002 health assessment (none) 1 = diabetes, 0 = no diabetes   [score]  DB1_0 QTL population f 14-40wks N=310
Leiter2 24003 histopathology (none) combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file)   [score]  Insulities_TimeOnset QTL population f 14-40wks N=310
Leiter2 24004 histopathology (none) insulitis severity / extent score (0-4, see excel file)   [score]  Insulitis QTL population f 14-40wks N=310
Leiter2 24005 histopathology (none) group mice by insulitis score (0-3, see excel file)   [score]  GroupInsulitis_Diabetes QTL population f 14-40wks N=310
Leiter2 24006 body weight (none) body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row)   [g]  30wk QTL population f 30wks N=310
Leiter2 24007 body weight (none) body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row)   [g]  40wk QTL population f 40wks N=310
Leiter2 24008 body weight (none) body Weight of whole mouse at time of DXA   [g]  BW QTL population f 14-40wks N=310
Leiter2 24009 DXA (none) bone Mineral Density, as determined by DXA (Dual emission X-ray Absorptiometry, head excluded)   [g/cm2]  BMD QTL population f 14-40wks N=310
Leiter2 24010 DXA (none) bone Mineral Content, as determined by DXA   [g]  BMC QTL population f 14-40wks N=310
Leiter2 24011 DXA (none) bone Mineral Area, as determined by DXA   [cm2]  Area QTL population f 14-40wks N=310
Leiter2 24012 DXA (none) weight of muscle and organs, as determined by DXA   [g]  Lean QTL population f 14-40wks N=310
Leiter2 24013 DXA (none) weight of fat, as determined by DXA   [g]  Fat QTL population f 14-40wks N=310
Leiter2 24014 DXA (none) total weight, as determined by DXA   [g]  Total QTL population f 14-40wks N=310
Leiter2 24015 DXA (none) percentage of fat of total weight as determined by DXA   [%]  %Fat QTL population f 14-40wks N=310
Leiter2 24016 hormone quantification (none) leptin in plasma   [ng/mL]  Leptin QTL population f 14-40wks N=310
Leiter2 24017 hormone quantification (none) insulin in plasma   [ng/mL]  Insulin QTL population f 14-40wks N=310
Leiter2 24018 lipid profile (none) total cholesterol in plasma   [mg/dL]  CHOL QTL population f 14-40wks N=310
Leiter2 24019 lipid profile (none) HDLD cholesterol in plasma   [mg/dL]  HDLD QTL population f 14-40wks N=310
Leiter2 24020 metabolic panel (none) glucose in plasma   [mg/dL]  Glucose QTL population f 14-40wks N=310
Leiter2 24021 lipid profile (none) non-Esterified Fatty Acids in plasma   [mEq/L]  NEFA QTL population f 14-40wks N=310
Leiter2 24022 lipid profile (none) triglycerides in plasma   [mg/dL]  TG QTL population f 14-40wks N=310
To see more rows use the paging control at top.



Project / data set:   Leiter2     a.k.a. Leiter_2009
Excel file:   Data_Description_NODx129_Leiter2009.xlsx
CSV file:   Leiter2009_NODx129_B37_Data.csv
Readme / text file:   readme_Leiter2009.txt
QC plots, figures, etc.:   QCReport_Leiter2009.pdf