MPD: Data set: Jentsch2

Cervantes MC, Laughlin RE, Jentsch JD. Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control. Psychopharmacology (Berl). 2013 Oct;229(3):515-25. doi: 10.1007/s00213-013-3135-4. Epub 2013 May 17. PubMed 23681162 FullText

Jentsch2 downloads
• Download Jentsch2 project data set animal data, as uploaded
• Download Jentsch2 animal data matrix with factor-related expansion applied as necessary
• Download Jentsch2 strain means, SD, N, etc. one row per strain/sex/measure
• Jentsch2 supplementary data

Ontology terms mapped to Jentsch2 measures:

MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001988 cocaine preference
MP:0002803 abnormal operant conditioning behavior
MP:0010698 abnormal impulsive behavior control
MP:0013189 abnormal exploration in a new environment
MP:0020158 abnormal behavioral response to cocaine
VT:0001392 locomotor behavior trait
VT:0002063 learning/memory/conditioning trait
VT:0010471 exploratory behavior trait
VT:0010473 impulsivity behavior trait
VT:0010531 operant conditioning behavior trait
VT:0010716 anxiety-related behavior trait
VT:0010718 response to cocaine trait

Investigators	J D Jentsch Binghamton University, Binghamton, NY
Participants	Cervantes MC, Laughlin RE
Contact	J D Jentsch jjentsch@binghamton.edu Lab web site
Part of a series:	• reversal learning, 51 BXD strains see Jentsch1 • cocaine study, 4 BXD strains (this project) Jentsch2
Acknowledgements	Funding provided by NIH DA031852, DA024635, DE019580, MH083270, NS062410
Project type	Phenotype strain survey data set
MPD identifiers	Jentsch2 MPD:497
Data changelog	No updates/corrections. Initial release date: 02/2014.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

"Self administration" = number of infusions earned during session
"Discrimination index" = index between active and inactive levers
"Time-out response" = number of responses made during post-infusion time-out periods
See protocol for additional clarification. Locomotor activity test involved baseline readings while other tests did not.

Procedures conducted:

• operant conditioning chamber

Intravenous self-administration of cocaine via activation of levers, and locomotor activity.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Jentsch2:1	Jentsch2	operant conditioning chamber	cocaine	number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule) [d] acquisition_FR1 49701	BXD	4	both	8-17wks	N=8

Jentsch2:2	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - self administration: number of infusions earned [n] infusions_FR1 49702 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=8

Jentsch2:6	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - discrimination index between active and inactive levers [%] discrimination_FR1 49706 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7

Jentsch2:10	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - time-out: number of responses [n] timeout_FR1 49710 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7

Jentsch2:14	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - self administration: number of infusions earned [n] infusions_FR2 49714 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6

Jentsch2:17	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - discrimination index between active and inactive levers [%] discrimination_FR2 49717 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6

Jentsch2:20	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - time-out: number of responses [n] timeout_FR2 49720 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6

Jentsch2:23	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - self administration: number of infusions earned [n] infusions_FR5 49723 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6

Jentsch2:26	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - discrimination index between active and inactive levers [%] discrimination_FR5 49726 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6

Jentsch2:29	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - time-out: number of responses [n] timeout_FR5 49729 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6

Jentsch2:32	Jentsch2	operant conditioning chamber	cocaine	horizontal beam breaks [n] activity 49732 baseline 5 mg/kg 10 mg/kg 20 mg/kg	BXD	4	f	8-17wks	N=13

Jentsch2: Drug study: Cocaine self-administration behavior and capacities for inhibitory control in 4 BXD recombinant inbred strains of mice (2013)