Jentsch1: Reversal learning in males of 51 BXD recombinant inbred strains of mice (2011)

Laughlin RE, Grant TL, Williams RW, Jentsch JD. Genetic dissection of behavioral flexibility: reversal learning in mice. Biol Psychiatry. 2011 Jun 1;69(11):1109-16. Epub 2011 Mar 9.   PubMed 21392734     FullText


       
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Participants J. David Jentsch       University of California, Los Angeles Los Angeles, CA
Robert W Williams       University of Tennessee Memphis, TN
With: Laughlin RE, Grant TL
ContactJ. David Jentsch     jentsch@psych.ucla.edu     Lab web site
Part of a series: • reversal learning, 51 BXD strains   (this project) Jentsch1
• cocaine study, 4 BXD strains   see Jentsch2
AcknowledgementsFunding provided by NIH DE019580, NS062410, NS048004, MH083270, MH083269, AA13499, AA13513, AA014425, DA021131
Project type Phenotype strain survey data set
MPD identifiersJentsch1     MPD:403
Data changelog No updates/corrections.       Initial release date: 06/2012.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Behavioral inflexibility was measured using discrimination acquisition and subsequent operant reversal learning to assess heritable deficits in the inhibitory control over behavior.

Summary of procedures that were conducted
• operant conditioning chamber Reversal learning test. Impulsivity, acquisition, reversal, conditioning. Performance and latency.
Mice: BXD   53 strains including progenitors   ♂   age 17wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Jentsch1 40301 operant conditioning chamber (none) number of initiated trials per daily session, acquisition phase   [n]  acq_initiated_trials BXD w/par 53 m 17wks N=3
    Jentsch1 40302 operant conditioning chamber (none) number of trials with no choice made in first 30 seconds, acquisition phase   [n]  acq_no_choice BXD w/par 53 m 17wks N=3
    Jentsch1 40303 operant conditioning chamber (none) average number of anticipatory responses per trial, acquisition phase   [n]  acq_anticipatory BXD w/par 53 m 17wks N=3
    Jentsch1 40304 operant conditioning chamber (none) average latency to initiate trial, acquisition phase   [s]  acq_latency_trial BXD w/par 53 m 17wks N=3
    Jentsch1 40305 operant conditioning chamber (none) average latency to make correct choice, acquisition phase   [s]  acq_latency_correct BXD w/par 53 m 17wks N=3
    Jentsch1 40306 operant conditioning chamber (none) average latency to retrieve food reward, acquisition phase   [s]  acq_latency_reward BXD w/par 53 m 17wks N=3
    Jentsch1 40307 operant conditioning chamber (none) number of initiated trials per daily session, reversal phase   [n]  revers_init_trials BXD w/par 53 m 17wks N=3
    Jentsch1 40308 operant conditioning chamber (none) number of trials with no choice made in first 30 seconds, reversal phase   [n]  revers_no_choice BXD w/par 53 m 17wks N=3
    Jentsch1 40309 operant conditioning chamber (none) average number of anticipatory responses per trial, reversal phase   [n]  revers_anticipatory BXD w/par 53 m 17wks N=3
    Jentsch1 40310 operant conditioning chamber (none) average latency to initiate trial, reversal phase   [s]  revers_latency_trial BXD w/par 53 m 17wks N=3
    Jentsch1 40311 operant conditioning chamber (none) average latency to make correct choice, reversal phase   [s]  revers_latency_correct BXD w/par 53 m 17wks N=3
    Jentsch1 40312 operant conditioning chamber (none) average latency to retrieve food reward, reversal phase   [s]  revers_latency_reward BXD w/par 53 m 17wks N=3
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