Jaxpheno8: Echocardiography and auditory brainstem response survey in males of 7 inbred strains of mice (2010)

Jackson Laboratory   With: Denegre J, Yang Y, Nicholson A, Davis C, Ryan J, McFarland H

       
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Institutional authorship Jackson Laboratory.
Participants Denegre J, Yang Y, Nicholson A, Davis C, Ryan J, McFarland H
ContactJames Denegre     james.denegre@jax.org
AffiliationJackson Laboratory Phenotyping Center
Project type Phenotype strain survey data set
MPD identifiersJaxpheno8     MPD:350
Data changelog 1 update/correction.       Initial release date: 08/2010.
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Animals were evaluated using ultrasound analysis and auditory evoked potential measurement.

Summary of procedures that were conducted
• ABR test Auditory brainstem response.
• echocardiography Cardiovascular function and morphology.
Mice: inbred   7 strains   ♂   age 10-13wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Jaxpheno8 35001 ABR test (none) auditory brainstem response (ABR) threshold, sound pressure level   [dB]     click    8kHz tone    16kHz tone    32kHz tone inbred 7 m 10-13wks N=9
    Jaxpheno8 35008 echocardiography (none) aortic mean peak pressure gradient   [mmHg]  Ao_Pmean inbred 6 m 12wks N=5
    Jaxpheno8 35009 echocardiography (none) aortic maximun pressure gradient   [mmHg]  Ao_Pmax inbred 6 m 12wks N=5
    Jaxpheno8 35010 echocardiography (none) aortic blood flow velocity   [mm/s]  Ao_V inbred 6 m 12wks N=5
    Jaxpheno8 35011 echocardiography (none) aortic blood flow mean peak velocity (velocity time integral)   [mm/s]  Ao_Vmean inbred 6 m 12wks N=5
    Jaxpheno8 35012 echocardiography (none) aortic blood flow maximum velocity (velocity time integral)   [mm/s]  Ao_Vmax inbred 6 m 12wks N=5
    Jaxpheno8 35013 echocardiography (none) aortic velocity time integral   [cm]  Ao_VTI inbred 6 m 12wks N=5
    Jaxpheno8 35015 echocardiography (none) heart rate, M-Mode parasternal short axis   [n/min]  HR_echo inbred 6 m 12wks N=5
    Jaxpheno8 35017 echocardiography (none) interventricular septum thickness   [mm]     diastolic    systolic inbred 6 m 12wks N=5
    Jaxpheno8 35019 echocardiography (none) left ventricle anterior wall thickness   [mm]     diastolic    systolic inbred 6 m 12wks N=5
    Jaxpheno8 35021 echocardiography (none) left ventricle posterior wall thickness   [mm]     diastolic    systolic inbred 6 m 12wks N=5
    Jaxpheno8 35023 echocardiography (none) left ventricle internal dimension   [mm]     diastolic    systolic inbred 6 m 12wks N=5
    Jaxpheno8 35025 echocardiography (none) left ventricle volume   [µL]     diastolic    systolic inbred 6 m 12wks N=5
    Jaxpheno8 35030 echocardiography (none) left ventricle cardiac output   [mL/min]  LV_CO inbred 6 m 12wks N=5
    Jaxpheno8 35031 echocardiography (none) left ventricle ejection fraction   [%]  LV_pctEF inbred 6 m 12wks N=5
    Jaxpheno8 35032 echocardiography (none) left ventricle fractional shortening   [%]  LV_pctFS inbred 6 m 12wks N=5
    Jaxpheno8 35033 echocardiography (none) left ventricle stroke volume   [µL]  LV_SV inbred 6 m 12wks N=5
    Jaxpheno8 35035 echocardiography (none) mitral valve peak A-wave velocity   [mm/s]  MV_A_V inbred 6 m 12wks N=5
    Jaxpheno8 35036 echocardiography (none) mitral valve peak E-wave velocity   [mm/s]  MV_E_V inbred 6 m 12wks N=5
    Jaxpheno8 35037 echocardiography (none) tricuspid valve peak A-wave velocity   [mm/s]  TV_A_V inbred 6 m 12wks N=4
    Jaxpheno8 35038 echocardiography (none) tricuspid valve peak E-wave velocity   [mm/s]  TV_E_V inbred 6 m 12wks N=4
    Jaxpheno8 35040 echocardiography (none) pulmonary artery blood flow velocity   [mm/s]  PA_V inbred 6 m 12wks N=5
    Jaxpheno8 35041 echocardiography (none) pulmonary artery blood flow mean peak velocity (velocity time integral)   [mm/s]  PA_Vmean inbred 6 m 12wks N=5
    Jaxpheno8 35042 echocardiography (none) pulmonary artery blood flow maximum velocity (velocity time integral)   [mm/s]  PA_Vmax inbred 6 m 12wks N=5
    Jaxpheno8 35043 echocardiography (none) pulmonary artery velocity time integral   [cm]  PA_VTI inbred 6 m 12wks N=5
    Jaxpheno8 35045 echocardiography (none) pulmonary artery mean pressure gradient   [mmHg]  PA_Pmean inbred 6 m 12wks N=5
    Jaxpheno8 35046 echocardiography (none) pulmonary artery maximum pressure gradient   [mmHg]  PA_Pmax inbred 6 m 12wks N=5
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