Hunter1: Transgenic survey: Metastatic progression of a mammary tumor determined by genetic background of 28 inbred strains of mice (1998)

Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, Hunter KW. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer. 1998 Aug 12;77(4):640-4.   PubMed 9679770  


       
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Participants Kent W Hunter       National Cancer Institute Bethesda, MD
With: Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH
ContactKent W Hunter     hunterk@mail.nih.gov     Lab web site
AcknowledgementsFunding provided by NIH CA06927; American Cancer Society IRG-191A; Department of Defense Breast Cancer Research Program DAMD17-7077; Commonwealth of Pennsylvania; Medical Research Council of Canada; Canadian Breast Cancer Research Initiative
Project type Phenotype strain survey data set
MPD identifiersHunter1     MPD:60
Data changelog No updates/corrections.       Initial release date: 05/2001.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of primary mammary tumor latency, severity and metastasis. Subjects were transgene positive (MMTV-PyMT) F1 virgin female progeny of different inbred strains of mice. Primary tumors were noted and confirmed. Mice were analyzed 40 days later (aged to permit metastatic progression).

Summary of procedures that were conducted
• histopathology Metastatic progression of mammary tumor and genetic background.
Mice: MMTV PyVT transgenic   28 strains   ♀   age various   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Hunter1 6004 histopathology (none) mammary tumor latency, days after birth   [d]  tum_lat MMTV PyVT transgenic 28 f None N=18
    Hunter1 6005 histopathology (none) tumor burden (body weight at sacrifice minus
body weight at diagnosis of primary tumor)   [g]
 tum_burd
MMTV PyVT transgenic 28 f None N=18
    Hunter1 6006 histopathology (none) number of pulmonary metastases   [n]  mets MMTV PyVT transgenic 28 f None N=19
    Hunter1 6007 histopathology (none) area of pulmonary metastases (x 103)   [µm2]  met_area MMTV PyVT transgenic 28 f None N=14
    Hunter1 6008 histopathology (none) total lung area (x 103)   [µm2]  tot_area MMTV PyVT transgenic 28 f None N=14
    Hunter1 6009 histopathology (none) number of pulmonary metastases per total lung area (x 10-9)   [n/µm2]  ratio_mta MMTV PyVT transgenic 28 f None N=14
    Hunter1 6010 histopathology (none) area of pulmonary metastases per number of metastases   [µm2/n]  met_size MMTV PyVT transgenic 28 f None N=14
    Hunter1 6011 histopathology (none) area of pulmonary metastases per total lung area   [ratio]  ratio_ata MMTV PyVT transgenic 28 f None N=14
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