HMDPpheno2: Plasma lipids and body composition in males of 99 strains of mice in the Hybrid Mouse Diversity Panel (HMDP) (2010)

Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res. 2010 Feb;20(2):281-90. Epub 2010 Jan 6.   PubMed 20054062     FullText


       
HMDPpheno2 downloads
• Download HMDPpheno2 project data set     one row per animal, one column per trait
• Download HMDPpheno2 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Brian J Bennett       University of North Carolina Chapel Hill, NC
Charles R Farber       University of Virginia Charlottesville, VA
Luz Orozco       University of California, Los Angeles Los Angeles, CA
Eleazar Eskin       University of California, Los Angeles Los Angeles, CA
Aldons J Lusis       University of California, Los Angeles Los Angeles, CA
With: Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA
ContactBrian J Bennett     bennettb@email.unc.edu
AffiliationHybrid Mouse Diversity Panel Group (HMDP)
AcknowledgementsFunding provided by NIH HL28481, HL30568, HL079353, DK072206, DK07789, DK074317, ES45530, HL080079; National Science Foundation grants 0513612, 0731455, and 0729049; American Heart Association AHA0825204F
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno2     MPD:464
Data changelog No updates/corrections.       Initial release date: 02/2013.
Formatted citation
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The Hybrid Mouse Diversity Panel (HMDP) includes inbred strains as well as AXB, BXA, BXD, and BXH strains. Data can be analyzed for all the HMDP strains together, or by strain panel subset.

Summary of procedures that were conducted
• NMR Percent fat.
• lipid profile Cholesterol, HDL, non-HDL, triglycerides, free fatty acids. 16h fast, plasma.
Mice: HMDP   99 strains including progenitors   ♂   age 16wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    HMDPpheno2 46401 lipid profile (none) HDL cholesterol (plasma HDL)   [mg/dL]  HDL HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46402 lipid profile (none) low density lipoprotein (plasma LDL) plus very low density lipoprotein (plasma VLDL)   [mg/dL]  LDL_VLDL HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46403 lipid profile (none) unesterified cholesterol (plasma CHOL)   [mg/dL]  CHOL_un HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46404 lipid profile (none) total cholesterol (plasma CHOL)   [mg/dL]  CHOL_tot HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46405 lipid profile (none) free fatty acids (plasma FFA)   [mEq/L]  FFA HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46406 lipid profile (none) triglycerides (plasma TG, 16h fast)   [mg/dL]  TG HMDP w/par 99 m 16wks N=7
    HMDPpheno2 46407 NMR (none) percent of tissue mass that is fat, whole body with head   [%]  pct_fat HMDP w/par 99 m 16wks N=7
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