Gros1: Susceptibility to infection with Candida albicans in females of 23 inbred strains of mice (and C5-allele status in 36 strains) (2011)

Radovanovic I, Mullick A, Gros P. Genetic control of susceptibility to infection with Candida albicans in mice. PLoS One. 2011 Apr 20;6(4):e18957.   PubMed 21533108     FullText


       
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Participants Irena Radovanovic       McGill University Montreal, Quebec CANADA
Alaka Mullick       Biotechnology Research Institute Montreal, Quebec CANADA
Philippe Gros       McGill University Montreal, Quebec CANADA
ContactPhilippe Gros     philippe.gros@mcgill.ca     Lab web site
AcknowledgementsFunding provided by Canadian Institutes of Health Research (CIHR)
Project type Phenotype strain survey data set
MPD identifiersGros1     MPD:385
Data changelog 1 update/correction.       Initial release date: 12/2011.
Formatted citation
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Summary of procedures that were conducted
• in vitro assay Susceptibility to infection with Candida albicans.
• genotype assessment C5 allele sufficiency or deficiency.
Mice: inbred   36 strains   ♀   age 8-12wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Gros1 38501 in vitro assay Candida albicans kidney fungal load 48h post-infection,
colony-forming units (log10 CFU per kidney)   [log(n)]
 fungal_load
inbred 23 f 8-12wks N=9
    Gros1 38502 in vitro assay Candida albicans susceptibility to C. albicans based on fungal load
(0=susceptible; 1=resistant)   [designation]
 susceptibility
inbred 23 f 8-12wks N=9
    Gros1 38503 genotype assessment (none) C5 allele (0=deficient, 1=sufficient)   [designation]  C5_allele inbred 36 f 8-12wks N=6
    All boxes