Ferris1: Host response to Influenza A (H1N1) in 8 inbred founder strains and 150+ emerging lines (pre-CC) of the Collaborative Cross (2012)

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.   PubMed 23468633     FullText


       
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Participants Martin T Ferris       University of North Carolina Chapel Hill, NC
Daniel Bottomly       Oregon Health & Science University Portland, OR
Shannon K McWeeney       Oregon Health & Science University Portland, OR
Mark T Heise       University of North Carolina Chapel Hill, NC
With: Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG
ContactMartin T Ferris     mtferris@email.unc.edu     Lab web site
AcknowledgementsFunding provided by AI081680, AI100625, AI084322, CA134240, CA069533, GM076468, RR024140; VIRGO consortium (BSIK 03012)
Project type Phenotype strain survey data set
MPD identifiersFerris1     MPD:476
Data changelog 1 update/correction.       Initial release date: 06/2013.
Formatted citation
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An assessment of emerging CC lines. Generations range from G2:F5 to G2:F11. Data for the 8 founder strains are also present.

Summary of procedures that were conducted
• body weight
• health assessment Clinical health assessment score and strain susceptibility index 4 days after infection with influenza A (H1N1) virus.
• in vitro assay Viral replication log titer 4 days after infection with influenza A (H1N1) virus. In vitro.
• histopathology Lungs and airway 4 days after infection with influenza A (H1N1) virus.
Mice: CC pre   163 strains including progenitors   ♀   age 8-16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Ferris1 47601 body weight influenza A (H1N1) virus  baseline body weight pre-infection (day 0)   [g]  bw_D0 CC pre w/CC8 163 f 8-16wks N=1
    Ferris1 47602 body weight influenza A (H1N1) virus percent change in body weight, day 4 post-infection   [%]  bw_change CC pre w/CC8 163 f 8-16wks N=1
    Ferris1 47603 health assessment influenza A (H1N1) virus clinical score, day 4 post-infection (score 0-4)   [score]  clinical_score CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47605 health assessment influenza A (H1N1) virus susceptibility to viral infection index (0=susceptible; 1= resistant)   [score]  susceptibility_index CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47606 in vitro assay influenza A (H1N1) virus viral replication log titer, day 4 post-infection (lung)   [n]  titer CC pre w/CC8 162 f 8-16wks N=1
    Ferris1 47607 histopathology influenza A (H1N1) virus virus-induced airway inflammation, day 4 post-infection (score 0-3)   [score]  airway_inflam CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47608 histopathology influenza A (H1N1) virus virus-induced airway neutrophils, day 4 post-infection (score 0-3)   [score]  airway_neut CC pre w/par 140 f 8-16wks N=1
    Ferris1 47609 histopathology influenza A (H1N1) virus virus-induced airway damage, day 4 post-infection (score 0-3)   [score]  airway_damage CC pre w/CC8 160 f 8-16wks N=1
    Ferris1 47610 histopathology influenza A (H1N1) virus virus-induced vascular inflammation (lung), day 4 post-infection (score 0-3)   [score]  vascular_inflam CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47611 histopathology influenza A (H1N1) virus virus-induced alveolar inflammation, day 4 post-infection (score 0-3)   [score]  alveolar_inflam CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47612 histopathology influenza A (H1N1) virus virus-induced alveolar damage, day 4 post-infection (score 0-3)   [score]  alveolar_damage CC pre w/CC8 161 f 8-16wks N=1
    Ferris1 47613 histopathology influenza A (H1N1) virus virus-induced pulmonary edema, day 4 post-infection (score 0-3)   [score]  pulmonary_edema CC pre w/par 138 f 8-16wks N=1
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