MPD: Data set: Ferris1

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28. PubMed 23468633 FullText

Ferris1 downloads
• Download Ferris1 project data set animal data, as uploaded
• Download Ferris1 animal data matrix with factor-related expansion applied as necessary
• Download Ferris1 strain means, SD, N, etc. one row per strain/sex/measure
• Ferris1 supplementary data

Ontology terms mapped to Ferris1 measures:

MA:0000415 lung
MP:0001259 abnormal body weight
MP:0001845 abnormal inflammatory response
MP:0020185 altered susceptibility to viral infection
VT:0001259 body mass
VT:0010439 response to viral infection trait

Investigators	Martin T Ferris University of North Carolina, Chapel Hill, NC Daniel Bottomly Oregon Health & Science University, Portland, OR Shannon K McWeeney Oregon Health & Science University, Portland, OR Mark T Heise University of North Carolina, Chapel Hill, NC
Participants	Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG
Contact	Martin T Ferris mtferris@email.unc.edu Lab web site
Acknowledgements	Funding provided by AI081680, AI100625, AI084322, CA134240, CA069533, GM076468, RR024140; VIRGO consortium (BSIK 03012)
Project type	Phenotype strain survey data set
MPD identifiers	Ferris1 MPD:476
Data changelog	1 update/correction. Initial release date: 06/2013.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An assessment of emerging CC lines. Generations range from G2:F5 to G2:F11. Data for the 8 founder strains are also present.

Procedures conducted:

• body weight
• health assessment		Clinical health assessment score and strain susceptibility index 4 days after infection with influenza A (H1N1) virus.
• in vitro assay		Viral replication log titer 4 days after infection with influenza A (H1N1) virus. In vitro.
• histopathology		Lungs and airway 4 days after infection with influenza A (H1N1) virus.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Ferris1:1	Ferris1	body weight	influenza A (H1N1) virus	body weight pre-infection (day 0) [g] bw_D0 47601	CC pre w/par	163	f	8-16wks	N=1

Ferris1:2	Ferris1	body weight	influenza A (H1N1) virus	percent change in body weight, day 4 post-infection [%] bw_change 47602	CC pre w/par	163	f	8-16wks	N=1

Ferris1:3	Ferris1	health assessment	influenza A (H1N1) virus	clinical score, day 4 post-infection (score 0-4) [score] clinical_score 47603	CC pre w/par	161	f	8-16wks	N=1

Ferris1:5	Ferris1	health assessment	influenza A (H1N1) virus	susceptibility to viral infection index (0=susceptible; 1= resistant) [score] susceptibility_index 47605	CC pre w/par	161	f	8-16wks	N=1

Ferris1:6	Ferris1	in vitro assay	influenza A (H1N1) virus	viral replication log titer, day 4 post-infection (lung) [n] titer 47606	CC pre w/par	162	f	8-16wks	N=1

Ferris1:7	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced airway inflammation, day 4 post-infection (score 0-3) [score] airway_inflam 47607	CC pre w/par	161	f	8-16wks	N=1

Ferris1:8	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced airway neutrophils, day 4 post-infection (score 0-3) [score] airway_neut 47608	CC pre w/par	140	f	8-16wks	N=1

Ferris1:9	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced airway damage, day 4 post-infection (score 0-3) [score] airway_damage 47609	CC pre w/par	160	f	8-16wks	N=1

Ferris1:10	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced vascular inflammation (lung), day 4 post-infection (score 0-3) [score] vascular_inflam 47610	CC pre w/par	161	f	8-16wks	N=1

Ferris1:11	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced alveolar inflammation, day 4 post-infection (score 0-3) [score] alveolar_inflam 47611	CC pre w/par	161	f	8-16wks	N=1

Ferris1:12	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced alveolar damage, day 4 post-infection (score 0-3) [score] alveolar_damage 47612	CC pre w/par	161	f	8-16wks	N=1

Ferris1:13	Ferris1	histopathology	influenza A (H1N1) virus	virus-induced pulmonary edema, day 4 post-infection (score 0-3) [score] pulmonary_edema 47613	CC pre w/par	138	f	8-16wks	N=1

Ferris1: Host response to Influenza A (H1N1) in 8 inbred founder strains and 150+ emerging lines (pre-CC) of the Collaborative Cross (2012)