Esposito1: Spontaneous morphological phenotypes in 6 inbred strains of mice (2013)

Serpi R, Klein-Rodewald T, Calzada-Wack J, Neff F, Schuster T, Gailus-Durner V, Fuchs H, Poutanen M, Hrabrè de Angelis M, Esposito I. Inbred wild type mouse strains have distinct spontaneous morphological phenotypes. Histol Histopathol. 2013 Jan;28(1):79-88.   PubMed 23233061  


   
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Participants Irene Esposito       Technische Universitaet Muenchen Munich GERMANY
With: Serpi R, Klein-Rodewald T, Calzada-Wack J, Neff F, Schuster T, Gailus-Durner V, Fuchs H, Poutanen M, Hrabě de Angelis M
ContactIrene Esposito     Esposito@lrz.tu-muenchen.de     Lab web site
AcknowledgementsFunding provided by the Academy of Finland (251736), Finnish Cardiovascular Foundation, Finnish Cultural Foundation, Sigrid Juselius Foundation, Company of Biologists, German Federal Ministry of Education and Research (NGFNPlus, 01GS0850), the German Research Foundation (SFB824, Project Z2), the European Community Erasmus Lifelong Learning Program (517860-LLP-1-2011-F1-ERASMUS-FEXI), European Community (EUMODIC LSHG-2006-037188)
Project type Phenotype archive study
MPD identifiersEsposito1     MPD:486
Data changelog No updates/corrections.       Initial release date: 08/2013.
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Frequency rates (%) of disorders seen during histopathology survey of various organs.

 Females Males
Organ       Disorder  

N animals examined

10 13 16 16 10 12   10 13 16 16 10 12
adrenal glandaccessory cortical nodule 10 8 30 17   20 10 8
adrenal glandsubcapsular cell hyperplasia 92 94 81 50   92 69 6 10
adrenal glandsubcapsular cell hypertrophy 17  
heartcalcification 23   23
heartlipomatosis 25   8
intestine, largePeyer's patch 20 77 38 25 40 25   50 54 56 19 30 33
intestine, smallPeyer's patch 50   12
kidneyfocal inflammation 17  
kidneyhydronephrosis 6 10   20
kidneypyelonephritis 20 12   12 20
liverextramedullary hematopoiesis 31 33   12 8
liverfocal necrosis 19 6 33   8 19 8
liversteatosis 6   77
lungbronchus associated lymphoid tissue 10 77 38 10 33   10 31 25 20 25
lungfocal infarction   19
lungpneumonia 40 8  
ovaryfollicular cyst 12              
ovarythickened membrane 31              
pancreaslipomatosis 50 67   19 6 50
salivary glandlipomatosis 12   12
stomachdilated glands 20  
testisatrophy               20
thyroidectopic thymus 6 10   6 10
urinary bladdercystitis 8 6   10 10

Dash (–) indicates 0 %.

Animal ages: 17 to 23 wks.