Donahue2: Characterization of skeletal geometry and bone strength in 10 inbred strains of mice (2004)

Donahue L, Beamer WG, Bogue MA, Churchill GA   With: Tsaih S-W, Sears AR, MacKenzie GW

       
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Participants Leah Rae Donahue       The Jackson Laboratory Bar Harbor, ME
Wesley G Beamer       The Jackson Laboratory Bar Harbor, ME
Molly A Bogue       The Jackson Laboratory Bar Harbor, ME
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Tsaih S-W, Sears AR, MacKenzie GW
ContactLeah Rae Donahue     lrd@jax.org     Lab web site
AcknowledgementsFunding provided by NIH DE13078; Department of the Army Grant DAMD17-03-1-0773
Project type Phenotype strain survey data set
MPD identifiersDonahue2     MPD:172
Data changelog No updates/corrections.       Initial release date: 05/2008.
Formatted citation
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Animals were assessed using densitometer dual energy X-ray absorptiometry (DXA), material testing solutions (MTS) systems, and computed tomography (µCT 40 and pQCT).

Summary of procedures that were conducted
• body weight
• muscle weights Quadriceps muscle.
• DXA Femur bone mineral density and content, thigh cross sectional areas.
• bone dimensions Femur.
• computed tomography Bone morphology (femur).
• biomechanical test Bone strength.
Mice: inbred   10 strains   ♀♂   age 16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Donahue2 17201 body weight (none) whole body weight (with head)   [g]  bw inbred 10 both 16wks N=10
    Donahue2 17202 DXA (none) volumetric bone mineral density (vBMD), whole left femur   [g/cm3]  femur_vBMD inbred 10 both 16wks N=10
    Donahue2 17203 DXA (none) cortical shell volumetric bone mineral density (vBMD), whole left femur   [g/cm3]  femur_cortical_BMD inbred 10 both 16wks N=10
    Donahue2 17204 DXA (none) cross sectional volumetric bone mineral density (vBMD), right femur mid-diaphysis   [g/cm3]  femur_shaft_BMD inbred 10 both 16wks N=11
    Donahue2 17205 DXA (none) cross sectional bone mineral content (BMC), right femur mid-diaphysis   [g]  femur_shaft_BMC inbred 10 both 16wks N=11
    Donahue2 17206 biomechanical test (none) maximum load on load-displacement curve   [N]  femur_peak_load inbred 10 both 16wks N=11
    Donahue2 17207 biomechanical test (none) displacement at peak load   [mm]  femur_peak_extension inbred 10 both 16wks N=11
    Donahue2 17208 biomechanical test (none) load at specimen failure (break point)   [N]  femur_break_load inbred 10 both 16wks N=11
    Donahue2 17209 biomechanical test (none) load at 95% break load   [N]  femur_yield_load inbred 10 both 16wks N=11
    Donahue2 17210 biomechanical test (none) area under load-displacement curve to break point   [N⋅mm]  femur_break_energy inbred 10 both 16wks N=11
    Donahue2 17211 biomechanical test (none) area under load-displacement curve to peak load   [N/mm2]  femur_peak_energy inbred 10 both 16wks N=11
    Donahue2 17212 biomechanical test (none) slope of force-displacement curve in linear region   [N/mm]  femur_stiffness inbred 10 both 16wks N=11
    Donahue2 17213 bone dimensions (none) length of right femur (condyles to rostral tip of greater trochanter)   [mm]  femur_length inbred 10 both 16wks N=11
    Donahue2 17214 bone dimensions (none) anterior to posterior (rostral to caudal) width of right femur (mid-diaphysis)   [mm]  femur_width_AP inbred 10 both 16wks N=11
    Donahue2 17215 bone dimensions (none) medial to lateral width of right femur (mid-diaphysis)   [mm]  femur_width_ML inbred 10 both 16wks N=11
    Donahue2 17216 computed tomography (none) cross sectional bone area (whole thigh area minus muscle area), femoral mid-diaphysis   [mm2]  femur_area inbred 10 both 16wks N=11
    Donahue2 17217 computed tomography (none) cortical thickness of right femur, pQCT   [mm]  femur_thickness_R1 inbred 10 both 16wks N=11
    Donahue2 17218 computed tomography (none) cortical thickness of right femur, µCT   [mm]  femur_thickness_R2 inbred 10 both 16wks N=11
    Donahue2 17219 computed tomography (none) cortical thickness of left femur, pQCT   [mm]  femur_thickness_L inbred 10 both 16wks N=10
    Donahue2 17220 computed tomography (none) periosteal (outer) circumference, femoral mid-diaphysis   [mm]  femur_out inbred 10 both 16wks N=10
    Donahue2 17221 computed tomography (none) endosteal (inner) circumference, femoral mid-diaphysis   [mm]  femur_in inbred 10 both 16wks N=10
    Donahue2 17222 DXA (none) cross-sectional area of thigh muscle and bone, femoral mid-diaphysis   [mm2]  thigh_area inbred 10 both 16wks N=10
    Donahue2 17223 DXA (none) cross-sectional thigh muscle area (thigh area minus femur area), femoral mid-diaphysis   [mm2]  thigh_muscle_area inbred 10 both 16wks N=10
    Donahue2 17224 muscle weights (none) weight of isolated right quadriceps muscle   [g]  quadricep_wt inbred 10 both 16wks N=11
    Donahue2 17230 biomechanical test (none) estimated elastic modulus   [N/mm2]  elastic_modulus inbred 10 both 16wks N=10
    Donahue2 17231 biomechanical test (none) estimated ultimate strength   [N]  ultimate_strength inbred 10 both 16wks N=10
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