Dickson2: Novelty-related behaviors and intravenous cocaine self-administration in a Diversity Outbred (DO) mouse population (2015)

Dickson PE, Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin DT, Chesler EJ. Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice. Psychopharmacology (Berl). 2015 Mar;232(6):1011-24. doi: 10.1007/s00213-014-3737-5. Epub 2014 Sep 20.   PubMed 25238945     FullText


       
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Participants Price E Dickson       The Jackson Laboratory Bar Harbor, ME
Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin D-T
ContactPrice E Dickson     price.dickson@jax.org
AcknowledgementsFunding provided by NIH CA034196, GM076468; acknowledge support from NIDA Drug Supply Program
Project type Phenotype strain survey data set
MPD identifiersDickson2     MPD:548
Data changelog No updates/corrections.       Initial release date: 06/2016.
Formatted citation
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FR = fixed ratio; PR = progressive ratio;

Summary of procedures that were conducted
• open field test Locomotor activity and exploratory behavior. 20 min test.
• hole board test Exploratory behavior. 10 min test.
• monitoring system Novelty preference test (preference for novel side vs. familiar side). 10 min test.
• operant conditioning chamber Intravenous self-administration of cocaine via activation of levers.
Mice: DO population   ♀♂   age 12-16wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Dickson2 54801 open field test (none) total distance traveled, 20 min test   [cm]  OFT_distance DO population both 12-16wks N=49
    Dickson2 54802 open field test (none) time spent in center, 20 min test   [s]  OFT_center DO population both 12-16wks N=49
    Dickson2 54811 monitoring system (none) percentage of total time spent in chamber with novel wall, 10 min test   [%]  novel_wall DO population both 12-16wks N=48
    Dickson2 54821 hole board test (none) number of hole pokes, 10 min test   [n]  hole_pokes DO population both 12-16wks N=46
    Dickson2 54831 operant conditioning chamber cocaine intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_infusions_mean DO population both 12-16wks N=35
    Dickson2 54832 operant conditioning chamber cocaine intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_active_mean DO population both 12-16wks N=35
    Dickson2 54833 operant conditioning chamber cocaine intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_inactive_mean DO population both 12-16wks N=35
    Dickson2 54841 operant conditioning chamber cocaine intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test   [n]  PR_infusions_breakpoint DO population both 12-16wks N=31
    Dickson2 54842 operant conditioning chamber cocaine intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test   [n]  PR_active DO population both 12-16wks N=31
    Dickson2 54843 operant conditioning chamber cocaine intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test   [n]  PR_inactive DO population both 12-16wks N=31
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