Crowley1: Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains (2012)

Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice. Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.   PubMed 21079646     FullText


       
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Participants James J Crowley       University of North Carolina Chapel Hill, NC
Howard L McLeod       University of North Carolina Chapel Hill, NC
Patrick F Sullivan       University of North Carolina Chapel Hill, NC
With: Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB
ContactJames J Crowley     crowley@unc.edu     Lab web site
AcknowledgementsFunding provided by NIH GM63340, MH90338, HD03110, MH080403, MH077139, MH074027.

Mice provided through a collaboration with the Mouse Phenome Project, The Jackson Laboratory.
Project type Phenotype strain survey data set
MPD identifiersCrowley1     MPD:394
Data changelog No updates/corrections.       Initial release date: 11/2011.
Formatted citation
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Mice were implanted with 60-day release haloperidol pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure). Mice were subjected to a battery of behavioral tests at specified times post-implant, including times post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort; baseline measurements were done prior to implantation, and plasma haloperidol levels were determined at specified times post-implant.

Summary of procedures that were conducted
• body weight Baseline vs. after haloperidol 60d implant.
• drug and metabolite quantification Haloperidol concentration (plasma). Baseline vs. during and after haloperidol 60d implant (several timepoints).
• inclined screen test Baseline vs. during and after haloperidol 60d implant (several timepoints).
• open field test Locomotor activity, exploratory behavior, involuntary movement. Baseline vs. haloperidol 60d implant (several timepoints). 60 min test.
• behavior observation Observed involuntary repetitive movement. Baseline vs. during and after haloperidol 60d implant (several timepoints).
Mice: inbred   27 strains   ♂   age 9-28wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Crowley1 39401 body weight haloperidol body weight   [g]     starting    ending inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39403 drug and metabolite quantification haloperidol plasma haloperidol concentration   [nM]     day:    30    60    90    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39407 inclined screen test haloperidol extrapyramidal side effects (EPS)   [s]     day:    0    3    7    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39412 open field test haloperidol distance traveled   [cm]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39417 open field test haloperidol vertical activity   [n]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39421 open field test haloperidol repetitive behavior (stereotypy)   [n]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39425 open field test haloperidol center occupancy   [%]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39429 behavior observation haloperidol tongue protrusion   [n]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39433 behavior observation haloperidol overt chewing movement   [n]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39437 behavior observation haloperidol subtle chewing movement   [n]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
    Crowley1 39441 behavior observation haloperidol jaw tremor   [s]     day:    0    30    60    120 inbred w/CC8 27 m 9-28wks N=6
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